Mycobacterium tuberculosis curli pili (MTP) deficiency is associated with alterations in cell wall biogenesis, fatty acid metabolism and amino acid synthesis

Metabolomics ◽  
2020 ◽  
Vol 16 (9) ◽  
Author(s):  
S. Ashokcoomar ◽  
K. S. Reedoy ◽  
S. Senzani ◽  
D. T. Loots ◽  
D. Beukes ◽  
...  
Author(s):  
Suman Maity ◽  
Amber Jannasch ◽  
Jiri Adamec ◽  
Thomas Nalepa ◽  
Tomas O. Höök ◽  
...  

2020 ◽  
Vol 11 (10) ◽  
pp. 8625-8636
Author(s):  
Zhi Chen ◽  
Shuangfeng Chu ◽  
Yusheng Liang ◽  
Tianle Xu ◽  
Yujia Sun ◽  
...  

Both mRNA and miRNA play an important role in the regulation of mammary fatty acid metabolism and milk fat synthesis.


2009 ◽  
Vol 32 (4) ◽  
pp. 353-361 ◽  
Author(s):  
Hiroshi Tsuji ◽  
Hiroyasu Shimizu ◽  
Tomotaro Dote ◽  
Kan Usuda ◽  
Masafumi Imanishi ◽  
...  

2008 ◽  
Vol 190 (13) ◽  
pp. 4512-4520 ◽  
Author(s):  
Jiae Yun ◽  
Byeonghwa Jeon ◽  
Yi-Wen Barton ◽  
Paul Plummer ◽  
Qijing Zhang ◽  
...  

ABSTRACT DksA is well known for its regulatory role in the transcription of rRNA and genes involved in amino acid synthesis in many bacteria. DksA has also been reported to control expression of virulence genes in pathogenic bacteria. Here, we elucidated the roles of a DksA-like protein (CJJ81176_0160, Cj0125c) in the pathogenesis of Campylobacter jejuni. As in other bacteria, transcription of stable RNA was repressed by the DksA-like protein under stress conditions in C. jejuni. Transcriptomic and proteomic analyses of C. jejuni 81-176 and an isogenic mutant lacking the DksA-like protein showed differential expression of many genes involved in amino acid metabolism, iron-related metabolism, and other metabolic reactions. Also, the C. jejuni DksA-like protein mutant exhibited a decreased ability to invade intestinal cells and induce release of interleukin-8 from intestinal cells. These results suggest that the DksA-like protein plays an important regulatory role in diverse metabolic events and the virulence of C. jejuni.


1997 ◽  
Vol 29 (11) ◽  
pp. 1543,1544
Author(s):  
Takashi Abe ◽  
Mihoko Inamori ◽  
Kouji Iida ◽  
Masahiro Tamura ◽  
Yoshimi Takiguchi ◽  
...  

BMC Genomics ◽  
2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Tamires Aparecida Bitencourt ◽  
Claudia Macedo ◽  
Matheus Eloy Franco ◽  
Marina Campos Rocha ◽  
Igor Sawasaki Moreli ◽  
...  

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