scholarly journals Use of serum albumin and activities of daily living to predict mortality in long-lived individuals over 95 years of age: a population-based study

AGE ◽  
2015 ◽  
Vol 37 (4) ◽  
Author(s):  
Zuyun Liu ◽  
Guangzhen Zhong ◽  
Shujuan Li ◽  
Wan Deng ◽  
Yuechan Zhang ◽  
...  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Lena Nilsson ◽  
Christer Andersson ◽  
Rune Sjödahl

Abstract Background During the first pandemic wave, Sweden experienced a high mortality rate. Home healthcare reflects a group of people especially vulnerable to coronavirus disease 2019 (COVID-19). We aimed to evaluate the pattern of comorbidity and frailty in a group of individuals having fatal outcomes in home healthcare during the COVID-19 pandemic March to September 2020, and to assess the contribution of COVID-19 in the fatal outcomes. Methods A cohort of adults with confirmed COVID-19 diagnosis that deceased in home healthcare between March and September 2020 were analysed in a retrospective study comprising home healthcare in 136 facilities in one Swedish county. Main outcome measures were comorbidity and frailty. Results One hundred fifty-five individuals (88 women, 67 men) aged 57–106 (median 88) years were included in the analysis. Nine had considerable frailty (ability to perform various activities of daily living but confined to bed or chair on occasion) and the remaining 146 had severe frailty (unable to perform activities of daily living and/or confined to bed or chair; dementia necessitating care). Three or more diagnoses besides COVID-19 were present in 142 individuals and another eight had two diagnoses in addition to COVID-19. In 20 (13%) individuals, COVID-19 was assessed as the principal cause of death, in 100 (64.5%) a contributing cause, and for the remaining 35 (22.5%) death was probably caused by another comorbidity. This seemed to change over the course of the COVID − 19 pandemic, with its contributing role decreasing from the middle of the summer. Conclusions Death in home healthcare during the first wave of the pandemic mostly affected individuals with severe frailty and comorbidity at very advanced ages. One fifth of the individuals who died in home health care had another cause than Covid-19. Trial registration Clinical Trials.gov NCT04642196 date 24/11/2020.


2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Thomas van Bemmel ◽  
Victoria Delgado ◽  
Jeroen J Bax ◽  
Jacobijn Gussekloo ◽  
Gerard J Blauw ◽  
...  

Author(s):  
Ben Brinkmann ◽  
Justine I Davies ◽  
Miles D Witham ◽  
Guy Harling ◽  
Till Bärnighausen ◽  
...  

Abstract Objectives The importance of impairment in performing Activities of Daily Living (ADL) is likely to increase in sub-Saharan Africa since few care options for affected people exist. This study investigated the prevalence of ADL impairment, the extent to which care-need was met and described characteristics of people with ADL impairment and unmet need in Burkina Faso. Methods This study used data from the CRSN Heidelberg Aging Study, a population-based study among 3,026 adults aged over 40 years conducted in rural Burkina Faso. Information on six basic ADL items was sought, with a follow-up question asking whether care-needs were not met, partially met or met. Bivariable correlations and multivariable logistic regression were used to determine sociodemographic and health characteristics associated with ADL impairment and unmet need. Results ADL impairment of any kind was reported by 1,202 (39.7%) respondents and was associated with older age (Adjusted Odds Ratio: 1.05 [95% CI: 1.04-1.06]), being a woman (1.33 [1.06-1.60]) and reporting depressive symptoms (1.90 [1.65-2.18]). Among those with ADL impairment, 67.8% had at least one unmet need. Severe ADL impairment was found in 202 (6.7%) respondents, who reported lower prevalence of unmet need (43.1%). Severe ADL impairment was associated with depressive symptoms (2.55 [2.11-3.07]) to a stronger degree than any ADL impairment. Discussion Prevalence of ADL impairment and unmet need was high in this setting. Variation in impairment across the population highlighted key groups for future interventions. Unmet need for care was highest in middle-aged adults, indicating a gap in care provision.


2020 ◽  
Author(s):  
Ke Han ◽  
Shengshu Wang ◽  
Wangping Jia ◽  
Wenzhe Cao ◽  
Miao Liu ◽  
...  

Abstract Background Objective deterioration in activities of daily living (ADLs) exists among older people, and particularly worsens with age. Considering the criterion standard of positive aging and longevity, little information focusing on centenarians is available. The present study aimed to examine the relationship between serum albumin and ADLs among centenarians in long-lived areas. Methods This population-based cross-sectional study investigated a complete sample of Chinese persons aged ≥100 years in Hainan, the longest-lived area of China (n=1002). We assessed serum albumin levels and basic and instrumental activities of daily living (BADLs and IADLs). Results Of 1002 participants included in the analysis, 287 (28.64%) had BADL disabilities and 648 (64.67%) had IADL disabilities. The median serum albumin level was 38.5 g/L (interquartile range, 36.2–41.3). The multivariable analyses controlling for socio-demographic characteristics, lifestyle, morbidities, and other influential factors showed that albumin level was associated with the total score of BADL ( standard β=0.335, P<0.001) and IADL ( standard β=0.206, P<0.001). With the increasing of albumin level, the risk of ADLs disability decreased (BADL: odds ratios [OR] = 0.835, 95% Confidence interval [CI]: 0.797-0.876; IADL: OR=0.863, 95%CI: 0.824-0.905). In the stratified analyses, similar results were found in both sex, but were more prominent in women. Conclusions Higher levels of serum albumin was a protective factor for the decline of ADLs in centenarians. This association can be observed in both genders and is more pronounced in women.


2019 ◽  
Author(s):  
Ke Han ◽  
Shengshu Wang ◽  
Wangping Jia ◽  
Wenzhe Cao ◽  
Miao Liu ◽  
...  

Abstract Background Objective deterioration in activities of daily living (ADL) exists in older people, particularly grows with age. While as the criterion standard of positive aging and longevity, little information that focuses on centenarians is available. The objective of this study is to examine the relationship between serum albumin and activities of daily living among centenarians in long-lived areas.Methods design—population-based cross-sectional study; setting—a complete sample study in Hainan, the longest-lived areas of China; subjects—Chinese older adults aged 100 and above (N=1002); measurements—serum albumin, basic and instrumental activities of daily living (BADL and IADL).Results Of 1002 participants included in the analysis 287(28.64%) were BADL disability, and 648(64.67%) were IADL disability. The median serum albumin level was 38.5 g/L (interquartile range, 36.2-41.3). In multivariable analyses controlling for socio-demographic characteristics, lifestyle characteristics and other influential factors, low albumin in the bottom quartile were associated with BADL disability (OR=5.994;95% CI: 3.542-10.143) and IADL disability (OR=4.398; 95% CI, 2.661-7.269). Serum albumin concentration showed a significant inverse linear relationship with ADL disability (P for trend <0.001). In sex-stratified analyses, the association was more pronounced in women. And we found a nonlinear relationship between serum albumin and IADL disability in female centenarians (P=0.025) from restricted cubic splines.Conclusions Low levels of albumin were associated with the decline in ADL function in centenarians, and this association was gender-specific and more prominent in the female.


Sign in / Sign up

Export Citation Format

Share Document