scholarly journals Cannabis/Cannabinoids for Treating COVID-19 Associated Neuropsychiatric Complications

2021 ◽  
Author(s):  
Jag H. Khalsa ◽  
Sanjay B. Maggirwar ◽  
Greg Bunt
Keyword(s):  
Neuropsychiatric Complications

scholarly journals Frequent neurocognitive deficits after recovery from mild COVID-19

2020 ◽  
Vol 2 (2) ◽  
Author(s):  
Marcel S Woo ◽  
Jakob Malsy ◽  
Jana Pöttgen ◽  
Susan Seddiq Zai ◽  
Friederike Ufer ◽  
...  
Keyword(s):  
Short Term Memory ◽  
Telephone Interview ◽  
Acute Infection ◽  
Young Patients ◽  
Cross Sectional Study ◽  
Cognitive Status ◽  
Neurocognitive Deficits ◽  
Cross Sectional ◽  
Neuropsychiatric Complications ◽  
Moderate Disease

Abstract Neuropsychiatric complications associated with coronavirus disease 2019 caused by the Coronavirus SARS-CoV-2 (COVID-19) are increasingly appreciated. While most studies have focussed on severely affected individuals during acute infection, it remains unclear whether mild COVID-19 results in neurocognitive deficits in young patients. Here, we established a screening approach to detect cognitive deficiencies in post-COVID-19 patients. In this cross-sectional study, we recruited 18 mostly young patients 20–105 days (median, 85 days) after recovery from mild to moderate disease who visited our outpatient clinic for post-COVID-19 care. Notably, 14 (78%) patients reported sustained mild cognitive deficits and performed worse in the Modified Telephone Interview for Cognitive Status screening test for mild cognitive impairment compared to 10 age-matched healthy controls. While short-term memory, attention and concentration were particularly affected by COVID-19, screening results did not correlate with hospitalization, treatment, viremia or acute inflammation. Additionally, Modified Telephone Interview for Cognitive Status scores did not correlate with depressed mood or fatigue. In two severely affected patients, we excluded structural or other inflammatory causes by magnetic resonance imaging, serum and cerebrospinal fluid analyses. Together, our results demonstrate that sustained sub-clinical cognitive impairments might be a common complication after recovery from COVID-19 in young adults, regardless of clinical course that were unmasked by our diagnostic approach.

Neuropsychiatric Complications of Antiretroviral Therapy

Drug Safety ◽  
2006 ◽  
Vol 29 (10) ◽  
pp. 865-874 ◽  
Author(s):  
Michelle S Cespedes ◽  
Judith A Aberg
Keyword(s):  
Antiretroviral Therapy ◽  
Neuropsychiatric Complications

Study the Prevalence of Depression in Patients Attending Comprehensive Care Centre, Islamabad, Pakistan

2021 ◽  
Vol 4 (9) ◽  
pp. 1-6
Author(s):  
Mehak Nimra ◽  
Sobia Yousaf ◽  
Huma Naz ◽  
Hira Nain ◽  
Tahreem Shahid ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Clinical Care ◽  
Comprehensive Care ◽  
P Value ◽  
People Living With Hiv ◽  
Care Centre ◽  
Neuropsychiatric Complications ◽  
Significant Difference ◽  
Prevalence Of Depression ◽  
Age Category

Abstract: Depression is one of the most common neuropsychiatric complications of HIV disease, and this leads to worse HIV-related health outcomes. With 350 million people affected worldwide, rates of depression are roughly two times greater in people living with HIV than in the general population. Objective: Determine prevalence of depression in patients attending Comprehensive Care Centre Shifa international Hospital, Islamabad Design: Descriptive cross-sectional quantitative study.  Settings: Shifa international Hospital, Islamabad Comprehensive Care Centre, Methods: This data is from a bigger study ‘prevalence of alcohol use disorders and depression in patients attending Comprehensive Care Centre (CCC). The study population consisted of PLWHA attending the CCC. Two hundred and seventy-two (N=272) participants from CCC attendants were recruited. All consenting male and female aged 18-65 years were interviewed using the researcher’s designed questioner to collect their socio-demographic characteristics. Fully completed questionnaires were entered into excel sheets and analyzed using the Statistical Package for Social Sciences (SPSS) Version 20.  Results: The overall prevalence of depression was 23.8%, with mild depression at 9.7%, moderate depression at 10.4% and severe depression accounting for 3.7%, respectively. Depression was associated with alcohol use (p=0.024). A significant difference between depression and age where depression levels worsens as age advances; respondents in age category of 18-21 years had less or no depression compared to those in the age category of 33 years and above. We found an association between depression and employment. Those laid-off work (1/3), and the retired (15%) had more depression compared to the employed (11%) or self-employed 6%, with a P value of 0.55 (borderline). On multivariate analysis severity of depression (OR=5.5, 95% CI of OR [2.1 –14.3], p<0.0001) was associated with male gender (OR=10, 95% CI of OR [3.6 –28.3], p<0.0001). Conclusion: The study findings indicate a high prevalence of depressive symptoms in patients attending the CCC. There is need to set-up appropriate interventions and strategies to reduce the prevalence of mental health disorders into routine HIV clinical care and support.

scholarly journals Neuropsychiatric Manifestations of Acute Intermittent Porphyria – A Diagnostic Dilemma

2020 ◽  
pp. 13-18
Author(s):  
Aratrika Sen ◽  
Tamoghna Bandyopadhyay ◽  
Ranjan Bhattacharyya
Keyword(s):  
Identical Condition ◽  
Acute Intermittent Porphyria ◽  
Normal Serum ◽  
Diagnostic Dilemma ◽  
Synthetic Pathway ◽  
Neuropsychiatric Complications ◽  
Neuropsychiatric Manifestations ◽  
Serum And Urine

Porphyrias are a group of inherited or acquired disorders of certain enzymes in the heme bio-synthetic pathway (also called porphyrin pathway). They are broadly classified as acute (hepatic) porphyrias and cutaneous (erythropoietic) porphyrias, based on the site of the overproduction and accumulation of the porphyrins or their chemical precursors. They manifest with either neuropsychiatric complications or skin problems or occasionally both. A clinically induced and histologically identical condition is called pseudo porphyria which is characterized by normal serum and urine porphyrin levels.

scholarly journals Organization of measures for the prevention of neuropsychiatric complications of toxoplasmosis and toxocariasis in Ukraine

2020 ◽  
Vol 8 (5-6) ◽  
pp. 19-24
Author(s):  
O.V. Bobrova ◽  
P.V. Nartov ◽  
N.H. Mikhanovska ◽  
K.A. Kryvonos
Keyword(s):  
Neuropsychiatric Complications

scholarly journals Depression and Catatonia: A Case of Neuropsychiatric Complications of Moyamoya Disease

Cureus ◽  
2018 ◽  
Author(s):  
Jonathan Lai ◽  
Abdurraoof Patel ◽  
Charlotte Dandurand ◽  
Peter Gooderham ◽  
Shaohua Lu
Keyword(s):  
Moyamoya Disease ◽  
Neuropsychiatric Complications

Prevention of Steroid-Induced Neuropsychiatric Complications With Neuroleptic Drugs: A Review

2021 ◽  
pp. 104990912110347
Author(s):  
Ivy Akid ◽  
Suzanne Nesbit ◽  
Julie Nanavati ◽  
Oscar Joseph Bienvenu ◽  
Thomas J. Smith
Keyword(s):  
Low Dose ◽  
Randomized Clinical Trials ◽  
Neuropsychiatric Symptoms ◽  
Review Literature ◽  
Treatment And Prevention ◽  
Neuropsychiatric Complications ◽  
History Of ◽  
Trial Evidence ◽  
History Of Depression ◽  
Positive Effect

Corticosteroids are used for a multitude of indications in palliative patients. In this narrative review, we aim to review literature on the treatment and prevention of neuropsychiatric complications of steroids. For prevention, only lamotrigine had a positive effect in a small number of studies. For treatment, olanzapine appears to be nearly universally effective at low doses, but randomized trial evidence is lacking. Further randomized clinical trials are necessary to elucidate data-driven guidelines for prevention and treatment of corticosteroid-induced neuropsychiatric symptoms. Until further data are available, it is reasonable to consider low dose olanzapine for any patient taking 40 mg of prednisone or its equivalent, especially those with a history of depression or neuropsychiatric symptoms.

Peculiarities of the microsocial environment in the formation of adjustment disorderin children with type 1 diabetes mellitus

2021 ◽  
pp. 27-34
Author(s):  
E. А. Mуkhailova ◽  
D. A. Mitelov
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Children And Adolescents ◽  
Emotional Disorders ◽  
Family Relationships ◽  
Psychological Health ◽  
Neuropsychiatric Complications ◽  
The Family

Currently, there is a global trend towards an increase in the incidence of type 1 diabetes mellitus (DM 1) among children and adolescents. It is characterized by a lifelong progressive course, manifested by endocrine and somatic disorders, as well as neurological and mental complications. The risk of the development of emotional disorders, cognitive dysfunction, adjustment disorder is largely determined by the microsocial environment of a child with DM 1. Objective — to study role of family in the formation of the disorders inmental and psychological health of children and adolescents with severe DM 1. Materials and methods. Examinations involved 285 patients with DM 1(126 children and 159 adolescents). The investigation design included clinical and psychopathological method, pathopsychological method, socio­psychological interviewing of a child and his/her family, test “Family sociogram”, projective picture tests “House­tree­man”, “Me and my disease”, “Kinetic picture of the family”. Results. It has been established that the level of psychological health of family of a child with DM 1 corresponded to the normal indicator in 20 % of cases. The factors have been determined that destabilize psychological health of the family, typology of family relationships with a sick child and their role in the formation of persistent neuropsychiatric complications. The factors of the microsocial environment affecting the formation of socio­psychological maladjustment of a child with DM were determined. The following risk factors of the formation of mental and neurological disorders in DM 1 children have been identified: the age of endocrine disease (DM)onset less than 7 years, the disease duration ≥ 5 years, frequent fluctuations in of glycemialevel, unsatisfactory self-control of the disease, late diagnosis of early and late complications related to the central nervous system, insufficient compliance, pathological types of family sociogram. An alternative method for diagnosing psychological problems in children and adolescents with diabetes ­ the use of projective methods has shown a high information content of target detection for the correction of emotional and behavioral disorders in the conditions of system «Life with diabetes».Conclusions. Socio-psychological patterns of maladaptation of children and adolescents with type 1 diabetes mellitushave been identified, which is important for determining the strategy of therapeutic intervention, socio-psychological support and prevention of social handicap.

Green tea might be effective in alleviating COVID-19 associated psychiatric complications: preliminary results from a pilot randomized controlled trial

2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Marjan Mahdavi-Roshan ◽  
Arsalan Salari ◽  
Eshagh Mohammadyari ◽  
Tofigh Yaghubi Kalurazi ◽  
Aydin Pourkazemi ◽  
...  
Keyword(s):  
Green Tea ◽  
Trait Anxiety ◽  
Controlled Trial ◽  
Black Tea ◽  
Analysis Of Covariance ◽  
Depression And Anxiety ◽  
Open Label ◽  
Content Type ◽  
Neuropsychiatric Complications ◽  
Psychiatric Complications

Purpose It is argued that COVID-19 patients show various neuropsychiatric symptoms, including fatigue, depression and anxiety. On the other hand, epidemiological and experimental evidence indicated that green tea could potentially have antiviral effects and ameliorate psychiatric disorders. However, there is a lack of clinical evidence. The purpose of this study was to investigate whether drinking green tea can clinically improve psychiatric complications of COVID-19 infection. Design/methodology/approach This study included 40 patients with laboratory confirmed mild-to-moderate COVID-19 disorder in the current randomized open-label controlled trial. Patients were instructed to include three cups/day of green tea (intervention) or black tea (control) to their usual diet for four weeks immediately after diagnosis of the disease. At the study baseline and after the intervention, the enrolled patients’ fatigue, depression and anxiety were assessed by the Chalder Fatigue Scale, Beck Depression Inventory-Fast Screen and State-Trait Anxiety Inventory questionnaires. Findings A total of 19 COVID-19 cases in the intervention group (mean age = 52 years) and 14 cases (mean age = 50 years) in the control group completed the study. Analysis of covariance adjusted for baseline levels, and confounders revealed that those who consumed three cups/day of green tea compared to the patients who received black tea experienced significantly lower fatigue, depression and state and trait anxiety levels (adjusted means for fatigue = 12.3 vs 16.2 (P = 0.03), depression = 0.53 vs 1.8 (P = 0.01), 37.4 vs 45.5 (P < 0.01) and 37.9 vs 45.2 (P < 0.01)). Research limitations/implications The open-label design may bias the evaluation of the self-reported status of fatigue, depression or anxiety as the main outcomes assessed. Moreover, as this study did not include patients with severe COVID-19, this might affect the generalizability of the present results. Thus, the recommendation of daily drinking green tea may be limited to the subjects diagnosed with mild-to-moderate type of infection or those with long-term neuropsychiatric complications owing to COVID-19. Besides, considering the ethical issues, this study could not exclude the drug therapy’s confounding effects; thereby, this point should be considered when interpreting the current results. Besides, it is worth noting that Guilan province in the north of Iran is recognized as a tea (and particularly green tea) producing region; thereby, it is an available and relatively inexpensive product. Considering this issue, the recommendation to consume this medicinal plant in adjunct to the routine treatment approach among patients with mild-to-moderate COVID-19 based on its beneficial effects may be widely accepted. Practical implications Green tea consumption could be considered an option to combat COVID-19 associated psychological complications, including fatigue, depression and anxiety among patients suffering from mild-to-moderate type of this viral infection. Originality/value To the best of the authors’ knowledge, in this study, for the first time, the effects of green tea compared to black tea on COVID-19 associated fatigue, depression and anxiety status within an open-label controlled trial have been investigated.

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