Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells

We studied the estrogenic activity and cellular effect of wild yam extract in MCF-7 human breast cancer cells. The extract increased the activity of the progesterone receptor and pS2 genes at the mRNA levels in human breast cancer MCF-7 cells, although the effects were not as prominent as those of 17β-estradiol (E2). Western blot analysis showed that the level of estrogen receptor α protein was down-regulated after treatment with E2 or wild yam extract. Wild yam extract also inhibited proliferation of MCF-7 cells. These data indicate that wild yam extract acts as a weak phytoestrogen and protects against proliferation in human breast carcinoma MCF-7 cells.

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The anticancer activity of root extract from Quercus acutissima Carruth. Via regulating apoptosis and autophagy in breast cancer cells

Journal of Ethnopharmacology ◽

10.1016/j.jep.2021.114730 ◽

2021 ◽

pp. 114730

Author(s):

Chen Chen ◽

Wenjing Ding ◽

Jun Li ◽

Xuexia Geng ◽

Haijun Zhang ◽

...

Keyword(s):

Breast Cancer ◽

Anticancer Activity ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Root Extract ◽

Quercus Acutissima

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Medicinal properties of Angelica archangelica root extract: Cytotoxicity in breast cancer cells and its protective effects against in vivo tumor development

Journal of Integrative Medicine ◽

10.1016/j.joim.2019.02.001 ◽

2019 ◽

Vol 17 (2) ◽

pp. 132-140 ◽

Cited By ~ 4

Author(s):

Carlos R. Oliveira ◽

Daniel G. Spindola ◽

Daniel M. Garcia ◽

Adolfo Erustes ◽

Alexandre Bechara ◽

...

Keyword(s):

Breast Cancer ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Tumor Development ◽

Root Extract ◽

Protective Effects ◽

Angelica Archangelica ◽

Medicinal Properties

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Studi Efikasi dan Keamanan Ekstrak Akar dan Daun Calotropis gigantea Terhadap Sel Kanker Kolon dan Sel Kanker Payudara Secara In Vitro

Journal of Islamic Medicine ◽

10.18860/jim.v1i2.4455 ◽

2017 ◽

Vol 1 (2) ◽

pp. 67-75

Author(s):

Roihatul Mutiah

Keyword(s):

Breast Cancer ◽

Colon Cancer ◽

Cancer Cells ◽

Breast Cancer Cells ◽

Ethanol Extract ◽

Root Extract ◽

Colon Cancer Cells ◽

Major Step ◽

Calotropis Gigantea

Development of phytopharmaca for cancer until now has become a major step in overcoming the failure of cancer therapy. Calotrophis gigantea is one of the scientifically proven plants both in vitro and in vivo as a chemopreventive agent. This study aims to explain the efficacy and safety of Calotropis gigantea leaf extract (EDCG) and Calotropis gigantea root extract (EACG) on NIH3T3 cell, colon cancer cell WiDr and T47D breast cancer cells. From the analysis of MTT and Selectivity Index (SI) analysis showed that ethanol extract of leaf Calotropis gigantea (EDCG) can inhibit selective growth of selective colon cancer cells (SI 3) but not selective in inhibiting the growth of breast cancer cells T47D (SI 3 ). Calotropic gigantea (EACG) root ethanol extract is not selective in inhibiting the growth of colon cancer cells WiDr and breast cancer cells T47D (SI 3). Therefore EDCG can be recommended as a Phytopharmaca candidate with further proof through clinical trials.

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