Qianliening capsule (前列宁胶囊) inhibits human prostate cell growth via induction of mitochondrion-dependent cell apoptosis

2012 ◽  
Vol 18 (11) ◽  
pp. 824-830 ◽  
Author(s):  
Zhen-feng Hong ◽  
Jiu-mao Lin ◽  
Xiao-yong Zhong ◽  
Ying Li ◽  
Jian-heng Zhou ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cell Apoptosis ◽  
Human Prostate ◽  
Prostate Cell ◽  
Dependent Cell

scholarly journals NELL2 Modulates Cell Proliferation and Apoptosis via ERK Pathway in the Development of Benign Prostatic Hyperplasia

2021 ◽  
Author(s):  
Jianmin Liu ◽  
Daoquan Liu ◽  
Xueneng Zhang ◽  
Yan Li ◽  
Xun Fu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Benign Prostatic Hyperplasia ◽  
Cell Apoptosis ◽  
Prostatic Hyperplasia ◽  
Human Prostate ◽  
Immunofluorescent Staining ◽  
Erk Pathway ◽  
Prostate Cell ◽  
Mesenchymal Transition ◽  
Dependent Cell

Benign prostatic hyperplasia (BPH) is a quite common illness but its etiology and mechanism remain unclear. Neural epidermal growth factor-like like 2 (NELL2) plays multifunctional roles in neural cell growth and is strongly linked to the urinary tract disease. Current study aims to determine the expression, functional activities and underlying mechanism of NELL2 in BPH. Human prostate cell lines and tissues from normal human and BPH patients were utilized. Immunohistochemical staining, immunofluorescent staining, RT-PCR and Western-blotting were performed. We further generated cell models with NELL2 silenced or overexpressed. Subsequently, proliferation, cycle, and apoptosis of prostate cells were determined by CCK-8 assay and flow cytometry analysis. The epithelial-mesenchymal transition (EMT) and fibrosis process were also analyzed. Our study revealed that NELL2 was upregulated in BPH samples and localized in the stroma and the epithelium compartments of human prostate tissues. NELL2 deficiency induced a mitochondrial-dependent cell apoptosis, and inhibited cell proliferation via phosphorylating ERK1/2 activation. Additionally, suppression of ERK1/2 with U0126 incubation could significantly reverse NELL2 deficiency triggered cell apoptosis. Consistently, overexpression of NELL2 promoted cell proliferation and inhibited cell apoptosis. However, NELL2 interference was observed no effect on EMT and fibrosis process. Our novel data demonstrated that upregulation of NELL2 in the enlarged prostate could contribute to the development of BPH through enhancing cell proliferation and inhibited a mitochondrial-dependent cell apoptosis via the ERK pathway. The NELL2-ERK system might represent an important target to facilitate the development of future therapeutic approaches in BPH.

scholarly journals In Search of the Molecular Mechanisms Mediating the Inhibitory Effect of the GnRH Antagonist Degarelix on Human Prostate Cell Growth

PLoS ONE ◽  
2015 ◽  
Vol 10 (3) ◽  
pp. e0120670 ◽  
Author(s):  
Monica Sakai ◽  
Daniel B. Martinez-Arguelles ◽  
Nathan H. Patterson ◽  
Pierre Chaurand ◽  
Vassilios Papadopoulos
Keyword(s):  
Cell Growth ◽  
Molecular Mechanisms ◽  
Gnrh Antagonist ◽  
Inhibitory Effect ◽  
Human Prostate ◽  
Prostate Cell

Androgen Regulation of Human Prostate Cell Growth

2000 ◽  
Author(s):  
Robert W. Harrison ◽  
III
Keyword(s):  
Cell Growth ◽  
Human Prostate ◽  
Prostate Cell ◽  
Androgen Regulation

Effect of permixon on human prostate cell growth: Lack of apoptotic action

The Prostate ◽  
2004 ◽  
Vol 61 (1) ◽  
pp. 73-80 ◽  
Author(s):  
Brian Hill ◽  
Natasha Kyprianou
Keyword(s):  
Cell Growth ◽  
Human Prostate ◽  
Prostate Cell

414: Induction of LNCAP Cell Growth, Androgen-Independence and Bone Metastasis by Human Prostate Fibroblasts of Different Zonal Origin

2006 ◽  
Vol 175 (4S) ◽  
pp. 135-135
Author(s):  
George N. Thalmann ◽  
H. Rhee Atlanta ◽  
R.A. Sikes ◽  
S. Pathak ◽  
Haiyen E. Zhau ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Cell Growth ◽  
Lncap Cell ◽  
Human Prostate ◽  
Androgen Independence

IPM-FISH, a new M-FISH approach using IRS-PCR painting probes: Application to the analysis of seven human prostate cell lines

2001 ◽  
Vol 30 (2) ◽  
pp. 143 ◽  
Author(s):  
Joan Aurich-Costa ◽  
Anne Vannier ◽  
Eric Grégoire ◽  
Frédérique Nowak ◽  
Dorra Cherif
Keyword(s):  
Cell Lines ◽  
Human Prostate ◽  
Prostate Cell ◽  
Painting Probes ◽  
Prostate Cell Lines

scholarly journals Zinc-dependent cell growth conferred by mutant tRNA synthetase.

1994 ◽  
Vol 269 (32) ◽  
pp. 20217-20220
Author(s):  
J.A. Landro ◽  
P. Schimmel
Keyword(s):  
Cell Growth ◽  
Trna Synthetase ◽  
Dependent Cell

scholarly journals IL-4 and anti-CD40 protect against Fasmediated B cell apoptosis and induce B cell growth and differentiation

1996 ◽  
Vol 8 (5) ◽  
pp. 791-798 ◽  
Author(s):  
Kenji Nakanishi ◽  
Kiyoshi Matsui ◽  
Shin-ichiro Kashiwamura ◽  
Yasuhiro Nishioka ◽  
Jun Nomura ◽  
...  
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Cell Apoptosis ◽  
Cell Growth And Differentiation
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