Mesenchymal stem cells and immune disorders: from basic science to clinical transition

2018 ◽  
Vol 13 (2) ◽  
pp. 138-151 ◽  
Author(s):  
Shihua Wang ◽  
Rongjia Zhu ◽  
Hongling Li ◽  
Jing Li ◽  
Qin Han ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Basic Science ◽  
Immune Disorders ◽  
Clinical Transition

Recent Advances in Endocrine, Metabolic and Immune Disorders: Mesenchymal Stem Cells (MSCs) and Engineered Scaffolds

2018 ◽  
Vol 18 (5) ◽  
pp. 466-469 ◽  
Author(s):  
Stefania Cantore ◽  
Vito Crincoli ◽  
Antonio Boccaccio ◽  
Antonio E. Uva ◽  
Michele Fiorentino ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Immune Disorders ◽  
Recent Advances

scholarly journals Strategies to Potentiate Paracrine Therapeutic Efficacy of Mesenchymal Stem Cells in Inflammatory Diseases

2021 ◽  
Vol 22 (7) ◽  
pp. 3397
Author(s):  
Yoojin Seo ◽  
Min-Jung Kang ◽  
Hyung-Sik Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Genetic Modification ◽  
Therapeutic Efficacy ◽  
Inflammatory Diseases ◽  
Review Article ◽  
Clinical Settings ◽  
Immune Disorders ◽  
Rapid Clearance ◽  
Physical Engineering

Mesenchymal stem cells (MSCs) have been developed as cell therapeutics for various immune disorders using their immunoregulatory properties mainly exerted by their paracrine functions. However, variation among cells from different donors, as well as rapid clearance after transplantation have impaired the uniform efficacy of MSCs and limited their application. Recently, several strategies to overcome this limitation have been suggested and proven in pre-clinical settings. Therefore, in this review article, we will update the knowledge on bioengineering strategies to improve the immunomodulatory functions of MSCs, including genetic modification and physical engineering.

scholarly journals Identifying the Therapeutic Significance of Mesenchymal Stem Cells

Cells ◽  
2020 ◽  
Vol 9 (5) ◽  
pp. 1145 ◽  
Author(s):  
Vineet Kumar Mishra ◽  
Hui-Hsuan Shih ◽  
Farzana Parveen ◽  
David Lenzen ◽  
Etsuro Ito ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Metabolic Disorders ◽  
Cellular Therapy ◽  
Inflammatory Diseases ◽  
Innate Immune ◽  
Immune Disorders ◽  
Therapeutic Role ◽  
Beneficial Effects ◽  
Immense Potential

The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immunosuppression and their therapeutic role in immune disorders. MSCs migrate towards inflamed microenvironments, produce anti-inflammatory cytokines and conceal themselves from the innate immune system. These signatures are the reason for the uprising in the sciences of cellular therapy in the last decades. Irrespective of their therapeutic role in immune disorders, some factors limit beneficial effects such as inconsistency of cell characteristics, erratic protocols, deviating dosages, and diverse transfusion patterns. Conclusive protocols for cell culture, differentiation, expansion, and cryopreservation of MSCs are of the utmost importance for a better understanding of MSCs in therapeutic applications. In this review, we address the immunomodulatory properties and immunosuppressive actions of MSCs. Also, we sum up the results of the enhancement, utilization, and therapeutic responses of MSCs in treating inflammatory diseases, metabolic disorders and diabetes.

Basic science of mesenchymal stem cells in spine surgery

2015 ◽  
Vol 27 (2) ◽  
pp. 72-75
Author(s):  
Hamid Hassanzadeh ◽  
Islam Elboghdady ◽  
Junyoung Ahn ◽  
Kern Singh
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Spine Surgery ◽  
Basic Science

Validation of reference and identity-defining genes in human mesenchymal stem cells cultured under unrelated fetal bovine serum batches for basic science and clinical application

2018 ◽  
Vol 14 (6) ◽  
pp. 837-846 ◽  
Author(s):  
Federica Banfi ◽  
Alessandra Colombini ◽  
Carlotta Perucca Orfei ◽  
Valentina Parazzi ◽  
Enrico Ragni
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Clinical Application ◽  
Bovine Serum ◽  
Basic Science ◽  
Fetal Bovine Serum ◽  
Human Mesenchymal Stem Cells ◽  
Fetal Bovine ◽  
Cells Cultured

scholarly journals Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Byung-Chul Lee ◽  
Kyung-Sun Kang
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Genetic Manipulation ◽  
Culture Method ◽  
Research Field ◽  
Innate Immune ◽  
Patient Specific ◽  
Immune Disorders ◽  
Bioactive Substances ◽  
Promising Alternative

Abstract Mesenchymal stem cells (MSCs) have recently been considered a promising alternative treatment for diverse immune disorders due to their unique biomedical potentials including the immunomodulatory property and ability to promote tissue regeneration. However, despite many years of pre-clinical studies in the research field, results from clinical trials using these cells have been diverse and conflicting. This discrepancy is caused by several factors such as poor engraftment, low survival rate, and donor-dependent variation of the cells. Enhancement of consistency and efficacy of MSCs remains a challenge to overcome the current obstacles to MSC-based therapy and subsequently achieve an improved therapeutic outcome. In this review, we investigated function enhancement strategies by categorizing as preconditioning, genetic manipulation, usage of supportive materials, and co-administration with currently used drugs. Preconditioning prior to MSC application makes up a large proportion of improvement strategies and preconditioning reagents include bioactive substances (cytokines, growth factors, and innate immune receptor agonists), hypoxia, and modification in culture method. With the piled results from previous studies using each method, disease- or patient-specific therapy has become more important than ever. On the other hand, genetic manipulation targeting therapeutic-associated factors or co-administration of biocompatible materials has also arisen as other therapeutic strategies. Thus, we summarized several specialized tactics by analyzing up-to-date results in the field and proposed some promising enhancement methods to improve the clinical outcomes for MSC therapy.

scholarly journals Mesenchymal Stem Cells in Lipogems, a Reverse Story: from Clinical Practice to Basic Science

2016 ◽  
pp. 109-122 ◽  
Author(s):  
Carlo Tremolada ◽  
Camillo Ricordi ◽  
Arnold I. Caplan ◽  
Carlo Ventura
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Clinical Practice ◽  
Basic Science

scholarly journals Therapeutic Functions of Stem Cells from Oral Cavity: An Update

2020 ◽  
Vol 21 (12) ◽  
pp. 4389 ◽  
Author(s):  
Ji Won Yang ◽  
Ye Young Shin ◽  
Yoojin Seo ◽  
Hyung-Sik Kim
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Dental Caries ◽  
Oral Cavity ◽  
Tissue Regeneration ◽  
Immune Regulation ◽  
Adult Stem Cells ◽  
Immune Disorders ◽  
Dental Stem Cells ◽  
Oral Cancers

Adult stem cells have been developed as therapeutics for tissue regeneration and immune regulation due to their self-renewing, differentiating, and paracrine functions. Recently, a variety of adult stem cells from the oral cavity have been discovered, and these dental stem cells mostly exhibit the characteristics of mesenchymal stem cells (MSCs). Dental MSCs can be applied for the replacement of dental and oral tissues against various tissue-damaging conditions including dental caries, periodontitis, and oral cancers, as well as for systemic regulation of excessive inflammation in immune disorders, such as autoimmune diseases and hypersensitivity. Therefore, in this review, we summarized and updated the types of dental stem cells and their functions to exert therapeutic efficacy against diseases.

Marrow Mesenchymal Stem Cells Cultured on Alumina Ceramics (From Basic Science to Clinical Applications)

2003 ◽  
Vol 240-242 ◽  
pp. 651-654 ◽  
Author(s):  
Hajime Ohgushi ◽  
Hiroko Machida ◽  
M. Ikeuchi ◽  
Tetsuya Tateishi ◽  
Yasuaki Tohma ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Basic Science ◽  
Clinical Applications ◽  
Alumina Ceramics ◽  
Marrow Mesenchymal Stem Cells ◽  
Cells Cultured

Human mesenchymal stem cells overexpressing therapeutic genes: From basic science to clinical applications for articular cartilage repair

2012 ◽  
Vol 22 (4) ◽  
pp. 197-208 ◽  
Author(s):  
Magali Cucchiarini ◽  
Jagadeesh K. Venkatesan ◽  
Myriam Ekici ◽  
Gertrud Schmitt ◽  
Henning Madry
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Articular Cartilage ◽  
Cartilage Repair ◽  
Basic Science ◽  
Human Mesenchymal Stem Cells ◽  
Clinical Applications ◽  
Articular Cartilage Repair ◽  
Therapeutic Genes
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