Geraniol ameliorated serum lipid profile and improved antioxidant defense system in pancreas, liver and heart tissues of alloxan-induced diabetic rats

Biologia ◽  
2021 ◽  
Author(s):  
Negin Eskandari ◽  
Seifollah Bahramikia ◽  
Abdelnasser Mohammadi ◽  
Majid Taati ◽  
Saba Safari Jafarabad
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Antioxidant Defense ◽  
Antioxidant Defense System ◽  
Diabetic Rats ◽  
Serum Lipid Profile ◽  
Defense System

scholarly journals Effects of enalapril and paricalcitol treatment on diabetic nephropathy and renal expressions of TNF-α, P53, Caspase-3 and Bcl-2 in STZ-induced diabetic rats

2019 ◽  
Author(s):  
Osama M. Ahmed ◽  
Tarek M. Ali ◽  
Mohamed A. Abdel Gaid ◽  
Ahmed A. Elberry
Keyword(s):  
Oxidative Stress ◽  
Wistar Rats ◽  
Antioxidant Defense ◽  
Caspase 3 ◽  
Enzyme Inhibitor ◽  
Elevated Serum ◽  
Antioxidant Defense System ◽  
Diabetic Rats ◽  
Defense System ◽  
Tnf Α

AbstractThis study aimed to assess the renopreventive effect of the angiotensin converting enzyme inhibitor (ACEI), enalapril, and/or vitamin D receptor (VDR) activator, paricalcitol, on streptozotocin (STZ) diabetes-induced nephropathy and to elucidate the mechanisms of action through investigation of the effects on renal oxidative stress, antioxidant defense system and expressions of TNF-α, P53, caspase-3, and Bcl-2. Diabetes mellitus was induced in fasting male Wistar rats by single intraperitoneal injection of STZ (45 mg /kg b.w.) dissolved in citrate buffer pH 4.5. Ten days after STZ injection, the diabetic rats were treated with enalapril (25 mg/l of drinking water) and/or paricalcitol (8 µg/kg b.w.per os) dissolved in 5% DMSO daily for 4 weeks. The obtained data revealed that the treatment of diabetic Wistar rats with enalapril and/or paricalcitol led to a significant decrease in the elevated serum urea, uric acid, creatinine and sodium, potassium levels; thereby reflecting improvement of the impaired kidney function. The deteriorated kidney lipid peroxidation, GSH content and GST and catalase activities in diabetic rats were significantly ameliorated as a result of treatment with enalapril and/or paricalcitol. The elevated fasting and post-prandial serum glucose levels and the lowered serum insulin and C-peptide levels were also improved. Moreover, the treatment of diabetic rats successfully prevented the diabetes-induced histopathological deleterious changes of kidney and islets of Langerhans of pancreas. In association, the immunohistochemically detected pro-inflammatory cytokine TNF-α and apoptotic mediators P53 and caspase-3 were remarkably decreased in kidney of diabetic rats as a result of treatment, while the expression of anti-apoptotic protein Bcl-2 was increased. Based on these findings, it can be concluded that enalapril and paricalcitol can prevent STZ diabetes-induced nephropathy though amelioration of the glycemic state and antioxidant defense system together with the suppression of oxidative stress, inflammation and apoptosis.

scholarly journals Resistance training alone or combined with leucine supplementation improves the serum lipid profile of diabetic rats, whereas leucine alone does not

2018 ◽  
Vol 52 (3) ◽  
pp. 146-151 ◽  
Author(s):  
Carlos Eduardo C. Martins ◽  
Vanessa B. de Sousa Lima ◽  
Henrique Quintas T. Ribeiro ◽  
Julio Tirapegui
Keyword(s):  
Resistance Training ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Control Diet ◽  
Density Lipoprotein ◽  
Diabetic Rats ◽  
Diet Group ◽  
Serum Lipid Profile ◽  
Leucine Supplementation ◽  
Streptozotocin Induced Diabetes

AbstractObjectives. Diabetes mellitus is associated with dyslipidemia, which contributes to a higher risk of thrombosis, atherosclerosis and cardiovascular disease. This study evaluated the effects of leucine and resistance training on the serum lipid profile in rats with streptozotocin-induced diabetes for 8 weeks.Methods. Wistar rats with neonatal streptozotocin-induced diabetes were treated with leucine supplementation (5%) and/or resistance training (3 days per week) for 8 weeks, and divided in DL (diabetic and leucine), DT (diabetic and resistance training group) and DLT (diabetic, leucine and resistance training) groups. Others 2 groups of animals received isonitrogen AIN-93M diet that was defined as a control diet: group D (diabetic untreated) and group C (non-diabetic).Results. The decrease in serum total cholesterol and increase in high-density lipoprotein cholesterol (HDL-C) was observed in the resistance training-induced diabetic rats when compared with diabetic rats. There was no change in serum lipid profile in leucine-supplemented diabetic rats and no synergistic effect of leucine and resistance training. The fasting glucose levels were reduced in all animals treated compared to D group.Conclusion. The diabetic trained rats demonstrate a protective effect of resistance training on the serum lipid profile.

scholarly journals Effects of Eight Weeks of Combined Training with Antioxidant Vitamins E and C on Glutathione, Glutathione Peroxidase, and Superoxide Dismutase in the Heart Tissue of Streptozotocin-induced Diabetic Rats

2021 ◽  
Vol In Press (In Press) ◽  
Author(s):  
Elaheh Heydarnia ◽  
Farzaneh Taghian ◽  
Khosrow Jalali ◽  
Mehrzad Moghadasi
Keyword(s):  
Superoxide Dismutase ◽  
Antioxidant Defense ◽  
Training Group ◽  
Antioxidant Defense System ◽  
Heart Tissue ◽  
Diabetic Rats ◽  
Defense System ◽  
Combined Training ◽  
Vitamins E And C ◽  
And Training

Background: Diabetes leads to metabolic disorders in the heart by creating free radicals and compromising the antioxidant defense system. Objectives: The aim of this study was to investigate the effect of eight weeks of combined training and supplementation with antioxidant vitamins E and C on the antioxidant capacity of heart tissue in streptozotocin-induced diabetic rats. Methods: Sixty male Sprague Dawley rats (weight: 280 ± 20 g; age: 2-3.5 months) were randomly divided into five groups as follows: (1) healthy control, (2) diabetic control, (3) diabetic + combined training, (4) diabetic + supplementation, and (5) diabetic + combined training + supplementation. The combined training protocol included incremental resistance training of 5 - 45% of rat weight on the ladder, and incremental endurance training was performed for 10 - 30 minutes at an intensity of 40 - 75% of maximum speed on the treadmill during eight weeks. The heart tissue was extracted and antioxidant enzymes were measured by lab spectroscopy 48 hours after the last training session. Data was analyzed using independent samples t-test, two-way ANOVA, and Bonferroni test (P ≤ 0.05). Results: The induction of diabetes significantly reduced glutathione (GSH; P = 0.001), glutathione peroxidase (GPx; P = 0.004), and superoxide dismutase (SOD; P = 0.001). In the treatment groups, a significant increase in the effect size of GSH (in the training and supplementation group: 6.45, training group: 3.18, and supplementation group: 2.92), GPX (in the training and supplementation group: 0.03, supplementation group: 0.023, and training group: 0.021), and SOD (in the training and supplementation group: 556.68, training group: 405.70, and supplementation group: 401.46 nmol / mL) was observed. Conclusions: Antioxidant supplementation and training by reducing the harmful effects of hyperglycemia strengthen the antioxidant defense system of heart tissue, and the combination of the two interventions is more effective than either alone.

Effects of Puffed Red Ginseng Power and Drink on Blood Glucose and Serum Lipid Profile in Streptozotocin-Induced Diabetic Rats

2015 ◽  
Vol 44 (10) ◽  
pp. 1415-1421
Author(s):  
Gun-Sub Shim ◽  
Ki-Seung Seong ◽  
Kyoung-Won Lee ◽  
Chang-Won Cho ◽  
Ok-Hwan Lee ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Diabetic Rats ◽  
Serum Lipid Profile ◽  
Red Ginseng

scholarly journals Antidiabetic Potency, Antioxidant Effects, and Mode of Actions of Citrus reticulata Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin in Nicotinamide/Streptozotocin-Induced Wistar Diabetic Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-21
Author(s):  
Alaa M. Ali ◽  
Mohamed Abdel Gabbar ◽  
Sanaa M. Abdel-Twab ◽  
Eman M. Fahmy ◽  
Hossam Ebaid ◽  
...  
Keyword(s):  
Antioxidant Defense ◽  
Elevated Serum ◽  
Antioxidant Defense System ◽  
Diabetic Rats ◽  
Oral Glucose ◽  
Citrus Reticulata ◽  
Defense System ◽  
Fruit Peel ◽  
Hydroethanolic Extract ◽  
Antioxidant Effects

This study is aimed at assessing the antihyperglycemic, antihyperlipidemic, and antioxidant effects of Citrus reticulata (C. reticulata) fruit peel hydroethanolic extract and two flavonoids, hesperidin and quercetin, in nicotinamide (NA)/streptozotocin- (STZ-) induced type 2 diabetic rats. In addition, GC-MS and HPLC-MS analyses of the extract were performed and the results indicated the presence of multiple flavonoids including hesperidin, quercetin, naringin, and polymethoxylated flavones (nobiletin and tangeretin). To achieve the aim of the study, diabetic rats with NA/STZ-induced T2DM were orally treated with C. reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin at a dose of 100 mg/kg b.w./day for four weeks. The treatments with C. reticulata fruit peel extract, hesperidin, and quercetin significantly ameliorated the impaired oral glucose tolerance; the elevated serum fructosamine level; the diminished serum insulin and C-peptide levels; the altered HOMA-IR, HOMA-IS, and HOMA-β cell function; the decreased liver glycogen content; the increased liver glucose-6-phosphatase and glycogen phosphorylase activities; the deleteriously affected serum lipid profile; the elevated serum AST and ALT activities; and the raised serum creatinine and urea levels in the diabetic rats. The treatments also produced remarkable improvement in the antioxidant defense system manifested by a decrease in the elevated liver lipid peroxidation and an increase in the lowered glutathione content and GPx, GST, and SOD activities. Furthermore, the three treatments enhanced the mRNA expression of GLUT-4 and the insulin receptor β-subunit, but only quercetin produced a significant increase in the expression of adiponectin in adipose tissue of diabetic rats. In conclusion, C. reticulata fruit peel hydroethanolic extract, hesperidin, and quercetin have potent antidiabetic effects which may be mediated through their insulinotropic effects and insulin-sensitizing actions. In addition, the alleviation of the antioxidant defense system by the extract, hesperidin, and naringin may have an important action to enhance the antidiabetic actions and to improve liver and kidney functions in NA/STZ-induced diabetic rats.

The effect of combination of aerobic training and oral administration of hydro extract of saffron (Crocus sativus) on serum lipid profile in streptozotosin induced diabetic rats

2011 ◽  
Vol 44 (13) ◽  
pp. S349-S350
Author(s):  
Roya Iraji ◽  
Mohamad Ali Azarbayjani ◽  
Mohamad Javad Rasaee ◽  
Peeri Maghsood ◽  
Asghar Nikpoor ◽  
...  
Keyword(s):  
Oral Administration ◽  
Lipid Profile ◽  
Serum Lipid ◽  
Aerobic Training ◽  
Diabetic Rats ◽  
Crocus Sativus ◽  
Serum Lipid Profile
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