In Malawi, as elsewhere in southern Africa, faith-based organisations (FBOs) have been integrated in the official response to HIV/AIDS. This new role, and the funding that accompanies it, has professionalised their traditional care activities around AIDS patients, widows and orphans, and it has also put them in charge of HIV prevention. As HIV preventers, they are asked to bridge epistemic differences between conflicting notions of sexuality and morality by reconciling public health messages, Christian teachings and local cosmologies. This becomes challenging when it comes to the question of sexuality education, specifically the promotion of abstinence, and condom use. Many FBO leaders’ response to this challenge is nuanced and defies stereotypes, as they try to balance their concern for young people, the demands of donors and the moral imperatives of their faith.