scholarly journals Bunched and Madm Function Downstream of Tuberous Sclerosis Complex to Regulate the Growth of Intestinal Stem Cells in Drosophila

2015 ◽  
Vol 11 (6) ◽  
pp. 813-825 ◽  
Author(s):  
Yingchao Nie ◽  
Qi Li ◽  
Alla Amcheslavsky ◽  
Juan Carlos Duhart ◽  
Alexey Veraksa ◽  
...  
Keyword(s):  
Stem Cells ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Intestinal Stem Cells

scholarly journals Tuberous sclerosis complex and Myc coordinate the growth and division of Drosophila intestinal stem cells

2011 ◽  
Vol 193 (4) ◽  
pp. 695-710 ◽  
Author(s):  
Alla Amcheslavsky ◽  
Naoto Ito ◽  
Jin Jiang ◽  
Y. Tony Ip
Keyword(s):  
Stem Cells ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Critical Role ◽  
Intestinal Stem Cells ◽  
Stem Cell Markers ◽  
Disc Cells ◽  
Epithelial Structure ◽  
Rates Of Growth ◽  
Adult Drosophila

Intestinal stem cells (ISCs) in the adult Drosophila melanogaster midgut can respond to damage and support repair. We demonstrate in this paper that the tuberous sclerosis complex (TSC) plays a critical role in balancing ISC growth and division. Previous studies have shown that imaginal disc cells that are mutant for TSC have increased rates of growth and division. However, we report in this paper that loss of TSC in the adult Drosophila midgut results in the formation of much larger ISCs that have halted cell division. These mutant ISCs expressed proper stem cell markers, did not differentiate, and had defects in multiple steps of the cell cycle. Slowing the growth by feeding rapamycin or reducing Myc was sufficient to rescue the division defect. The TSC mutant guts had a thinner epithelial structure than wild-type tissues, and the mutant flies were more susceptible to tissue damage. Therefore, we have uncovered a context-dependent phenotype of TSC mutants in adult ISCs, such that the excessive growth leads to inhibition of division.

scholarly journals mTOR Signaling and Neural Stem Cells: The Tuberous Sclerosis Complex Model

2018 ◽  
Vol 19 (5) ◽  
pp. 1474 ◽  
Author(s):  
Alice Polchi ◽  
Alessandro Magini ◽  
Danila Meo ◽  
Brunella Tancini ◽  
Carla Emiliani
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Complex Model ◽  
Mtor Signaling

scholarly journals Sustained Activation of mTOR Pathway in Embryonic Neural Stem Cells Leads to Development of Tuberous Sclerosis Complex-Associated Lesions

2011 ◽  
Vol 9 (5) ◽  
pp. 447-462 ◽  
Author(s):  
Laura Magri ◽  
Marco Cambiaghi ◽  
Manuela Cominelli ◽  
Clara Alfaro-Cervello ◽  
Marco Cursi ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Mtor Pathway ◽  
Associated Lesions ◽  
Sustained Activation

Predictors of Efficacy in Patients with Adjunctive Everolimus Therapy for Treatment-Resistant Seizures Associated with Tuberous Sclerosis Complex

2017 ◽  
Vol 48 (S 01) ◽  
pp. S1-S45
Author(s):  
G. Wiegand ◽  
T. Polster ◽  
C. Hertzberg ◽  
A. Wiemer-Kruel ◽  
J. French ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Treatment Resistant

Everolimus Reduces Seizure Frequency in Tuberous Sclerosis Complex

2017 ◽  
Vol 48 (S 01) ◽  
pp. S1-S45
Author(s):  
T. Stapper ◽  
D. Valcheva ◽  
T. Höll ◽  
T. Rosenbaum
Keyword(s):  
Tuberous Sclerosis ◽  
Seizure Frequency ◽  
Tuberous Sclerosis Complex

Good seizure outcome after epilepsy surgery in young children with tuberous sclerosis complex

2006 ◽  
Vol 37 (03) ◽  
Author(s):  
C Krahn-Peper ◽  
IEB Tuxhorn ◽  
K Ahlbory ◽  
F Behne ◽  
H Pannek
Keyword(s):  
Young Children ◽  
Tuberous Sclerosis ◽  
Epilepsy Surgery ◽  
Tuberous Sclerosis Complex ◽  
Seizure Outcome

Renal Manifestations of Tuberous Sclerosis Complex

2020 ◽  
Vol 7 (3) ◽  
pp. 5-19
Author(s):  
Nikhil Nair ◽  
Ronith Chakraborty ◽  
Zubin Mahajan ◽  
Aditya Sharma ◽  
Sidarth Sethi ◽  
...  
Keyword(s):  
Tuberous Sclerosis ◽  
Tuberous Sclerosis Complex ◽  
Gene Disruption ◽  
Treatment Guidelines ◽  
Renal Cysts ◽  
Skin Lesions ◽  
Multiple Organ ◽  
Tsc2 Gene ◽  
Genetic Condition ◽  
Organ Systems

Tuberous sclerosis complex (TSC) is a genetic condition caused by a mutation in either the TSC1 or TSC2 gene. Disruption of either of these genes leads to impaired production of hamartin or tuberin proteins, leading to the manifestation of skin lesions, tumors and seizures. TSC can manifests in multiple organ systems with the cutaneous and renal systems being the most commonly affected. These manifestations can secondarily lead to the development of hypertension, chronic kidney disease, and neurocognitive declines. The renal pathologies most commonly seen in TSC are angiomyolipoma, renal cysts and less commonly, oncocytomas. In this review, we highlight the current understanding on the renal manifestations of TSC along with current diagnosis and treatment guidelines.

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