Effects of sex steroid hormones, thyroid hormone levels, and insulin regulation on thyrotoxic periodic paralysis in Chinese men

PURPOSE: To examine the relationship between plasma levels of reproductive sex steroid hormones in postmenopausal women and their reported fat intake.METHODS: We measured plasma sex steroid hormones levels in plasma collected in 1989 and 1990 from 381 healthy postmenopausal women. For each woman, we measured fat intake in 1986 and 1990 by a food-frequency questionnaire. The cross-sectional associations between the percentage of energy from total and specific types of dietary fat intake and plasma hormone levels were assessed by linear regression, controlling for energy intake, obesity, and protein intake.RESULTS: The plasma estradiol level was 4.3% lower (95% confidence limits, −8.3%, −0.2%) for a substitution of 5% of energy from fat intake for an equivalent amount of energy from carbohydrate when adjusted for obesity and other covariates. Estradiol was also inversely associated with all other fat types except trans fat; the inverse associations with vegetable fat and marine omega-3 fats were statistically significant.CONCLUSION: We observed an inverse association between total fat intake averaged over 4 to 5 years and estradiol levels. This result is inconsistent with the hypothesis that fat intake predisposes to breast cancer risk by raising endogenous estrogen levels.

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Thyroid hormone levels in flow-challenged adult salmon (Salmo salar L.)

Canadian Journal of Zoology ◽

10.1139/z89-263 ◽

1989 ◽

Vol 67 (8) ◽

pp. 1851-1855 ◽

Cited By ~ 4

Author(s):

A. F. Youngson ◽

H. A. McLay

Keyword(s):

Thyroid Hormone ◽

Steroid Hormones ◽

Salmo Salar ◽

Water Velocity ◽

Male Fish ◽

Hormone Levels ◽

Thyroid Hormone Levels ◽

Circulating Levels

Circulating levels of thyroid and steroid hormones in salmon (Salmo salar) that had spent one winter in seawater have been determined in fish at rest and after a 4-h exposure to increased water velocity. The responses of fish of both sexes to this challenge were examined in April and June, while the fish were in seawater; sexually maturing males only were examined in freshwater in August and November. Mean thyroxine levels in resting controls ranged from 8.8 to 15.2 ng/mL. Mean thyroxine levels in challenged fish were significantly greater on each occasion. In male fish, 11-oxotestosterone levels were reduced after challenge, while androstenedione levels in females remained unchanged. In April, thyroxine levels after challenge were correlated with 11-oxotestosterone levels in males and with androstenedione levels in females.

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Interactions among age, adiposity, bodyweight, lifestyle factors and sex steroid hormones in healthy Singaporean Chinese men

Asian Journal of Andrology ◽

10.1111/j.1745-7262.2007.00322.x ◽

2007 ◽

Vol 9 (5) ◽

pp. 611-621 ◽

Cited By ~ 29

Author(s):

Victor H. H. Goh ◽

Terry Y. Y. Tong ◽

Helen P. P. Mok ◽

Baharudin Said

Keyword(s):

Steroid Hormones ◽

Lifestyle Factors ◽

Sex Steroid Hormones ◽

Sex Steroid ◽

Chinese Men

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Assessment of comorbidities in patients with deranged thyroid hormone levels

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20202938 ◽

2020 ◽

Vol 9 (7) ◽

pp. 1044

Author(s):

Sneha D. Narwade ◽

Rohidas M. Barve

Keyword(s):

Thyroid Hormone ◽

Drug Interactions ◽

Tertiary Care ◽

Periodic Paralysis ◽

Thyroid Disorders ◽

Care Hospital ◽

Hypokalemic Periodic Paralysis ◽

Hormone Levels ◽

Thyroid Hormone Levels ◽

Thyroid Ophthalmopathy

Background: There is association of deranged thyroid hormone levels with various co-morbidities. Drugs for comorbidity may interact with each other and affect the outcome of treatment. So, this study was planned to find out comorbidities with deranged thyroid hormone levels and various possible drug interactions.Methods: It was a prospective, observational study carried out at tertiary care hospital from November 2017 to June 2018. Thyroid hormonal levels reports were followed in OPD and online information system facility. Drugs interactions were checked by referring standard pharmacology textbooks, review articles and Medscape drug interaction checker. Approval from the Institutional Ethics Committee was taken before initiation of the study. Patients with deranged thyroid hormone levels were included in the study.Results: Study was conducted in 111 patients of thyroid disorders. Spondylitis, asthma, acne cases were seen in hypothyroid patients whereas hypokalemic periodic paralysis, thyroid ophthalmopathy statistically significantly seen in hyperthyroid patients. Various concurrent medications such as calcium, carbamazepine decreases the effects of levothyroxine. For management of comorbidities various drugs are given which also interact among themselves significantly.Conclusions: Diabetes mellites, obesity, spondylitis, lichen planus were more common in hypothyroidism while comorbidities like hypertension, hypokalemic periodic paralysis, thyroid ophthalmopathy were found to be more in hyperthyroidism. Incidence of drug interactions is found to be more with increased use of medications for comorbidities, so physicians should be careful while prescribing them. Due to drug interactions desired effects of drugs given for thyroid disorders may not be observed.

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