Thyroid hormone levels in flow-challenged adult salmon (Salmo salar L.)

1989 ◽  
Vol 67 (8) ◽  
pp. 1851-1855 ◽  
Author(s):  
A. F. Youngson ◽  
H. A. McLay
Keyword(s):  
Thyroid Hormone ◽  
Steroid Hormones ◽  
Salmo Salar ◽  
Water Velocity ◽  
Male Fish ◽  
Hormone Levels ◽  
Thyroid Hormone Levels ◽  
Circulating Levels

Circulating levels of thyroid and steroid hormones in salmon (Salmo salar) that had spent one winter in seawater have been determined in fish at rest and after a 4-h exposure to increased water velocity. The responses of fish of both sexes to this challenge were examined in April and June, while the fish were in seawater; sexually maturing males only were examined in freshwater in August and November. Mean thyroxine levels in resting controls ranged from 8.8 to 15.2 ng/mL. Mean thyroxine levels in challenged fish were significantly greater on each occasion. In male fish, 11-oxotestosterone levels were reduced after challenge, while androstenedione levels in females remained unchanged. In April, thyroxine levels after challenge were correlated with 11-oxotestosterone levels in males and with androstenedione levels in females.

Bulbospinal serotonergic activity during changes in thyroid status

1998 ◽  
Vol 76 (12) ◽  
pp. 1120-1131 ◽  
Author(s):  
William N Henley ◽  
Linda L Bellush ◽  
Marc Tressler
Keyword(s):  
Thyroid Hormone ◽  
Primary Hypothyroidism ◽  
Glycemic Status ◽  
Thyroid Status ◽  
Hormone Levels ◽  
Serotonergic Activity ◽  
Thyroid Hormone Levels ◽  
The Brain ◽  
Circulating Levels ◽  
Very High

A three-part study explored the basis for an interaction between changes in thyroid status and bulbospinal serotonin (5HT) metabolism. In experiment 1, three well-characterized models of primary hypothyroidism were all accompanied by significant increases in 5HT metabolism. In experiment 2, circulating thyroid hormone levels were experimentally varied from very low methimazole (Meth) treatment to very high (T3 implants: 2.5, 5.0, or 7.5 mg triiodothyronine). As in experiment 1, Meth led to elevated 5HT. Hyperthyroidism was accompanied by significant reductions in 5HT, while urinary norepinephrine excretion paralleled 5HT. In experiment 3, rats were subjected to Meth either 2 weeks before or after induction of diabetes with streptozotocin (Stz). Meth prevented Stz-associated reductions in 5HT and attenuated development of hyperphagia. Meth could not reverse established Stz-associated reduction in 5HT or hyperphagia, although both were slightly attenuated. Thus, although the first two experiments argue for a simple inverse relationship between circulating thyroid hormone levels and 5HT in the brain, experiment 3 demonstrated that Stz-associated decrements in 5HT could not be reversed by subsequent lowering of circulating thyroid hormone. Nor did accompanying measurements indicate that glycemic status or circulating levels of leptin were important predictors of 5HT. Thus the interaction between thyroid hormones and 5HT is both more subtle and more complex than previously thought.Key words: hypothyroidism, hyperthyroidism, serotonin, diabetes mellitus.

Serum T3 and T4 Levels in Sick Children

PEDIATRICS ◽  
1976 ◽  
Vol 58 (5) ◽  
pp. 776-776
Author(s):  
J. N. Carter ◽  
J. M. Corcoran ◽  
C. J. Eastman ◽  
L. Lazarus ◽  
M. O'Halloran
Keyword(s):  
Thyroid Hormone ◽  
Normal Range ◽  
Hormone Levels ◽  
Serum T3 ◽  
The Mean ◽  
Thyroid Hormone Levels ◽  
Sick Children ◽  
Circulating Levels ◽  
Tsh Levels ◽  
Sick Euthyroid

We have reported that most adults with severe, chronic, nonthyroidal illnesses (i.e., sick euthyroid patients) have significantly decreased circulating levels of triiodothyronine (T3) and thyroxine (T4), whilst the thyrotropin (TSH) levels are not elevated.1 The T3 levels are usually reduced into the hypothyroid range, whilst the T4 levels generally remain within the normal range. The patients in that study were aged from 21 to 84 years. We have recently concluded a study of circulating thyroid hormone levels in children of various ages and have found that the mean levels of both T3 and T4 are higher than in adults.

Evaluation of Positive Inotropic Drug Effects on Thyroid Hormone Levels after Open Heart Surgery

2015 ◽  
Vol 16 (2) ◽  
pp. 78
Author(s):  
Umit Kervan ◽  
Anil Ozen ◽  
Utku Unal ◽  
Irfan Tasoglu ◽  
Mahmut Mustafa Ulas ◽  
...  
Keyword(s):  
Drug Therapy ◽  
Thyroid Hormone ◽  
Heart Surgery ◽  
Open Heart Surgery ◽  
Open Heart ◽  
Inotropic Drug ◽  
Hormone Levels ◽  
Inotropic Drugs ◽  
Positive Inotropic Drug ◽  
Thyroid Hormone Levels

<p><b>Objective:</b> The aim of this study was to examine the effects of positive inotropic drugs, including adrenaline, dopamine, and dobutamine on thyroid hormone levels following open heart surgery.</p><p><b>Methods:</b> We analyzed free thyroid hormones (FT3 and FT4) and thyroid-stimulating hormones (TSH) in 200 consecutive patients undergoing open heart surgery. Patients were divided into 5 groups according to the inotropic drug administration as follows: Group A (n = 46) received dopamine alone; Group B (n = 40), dopamine and dobutamine; Group C (n = 36), dopamine, dobutamine, and adrenaline; Group D (n = 32), adrenaline alone; and Group E (n = 46), placebo. Procedural factors affecting thyroid hormones were recorded and included cardiopulmonary bypass (CPB) time, cross-clamping time, degree of hypothermia, and the duration and doses of positive inotropic drugs. Blood samples for hormone assays were collected before initiation of inotropic drug therapy (baseline) and postoperatively at 24, 72, and 120 hours after drug therapy.</p><p><b>Results:</b> FT3, FT4, and TSH levels at baseline were similar in all groups. Although there was a trend showing very slight increases in thyroid hormone levels from baseline to the 24th, 72nd, and 120th postoperative hours after drug therapy, these changes were not significant, and there were also no significant differences between the groups. There was also no significant statistical difference in CPB time, cross-clamping time, degree of hypothermia, and duration and doses of positive inotropic drugs between groups.</p><p><b>Conclusion:</b> Although thyroid hormone levels were affected by positive inotropic drug usage after open heart surgery, this effect was not significant and thyroid hormone levels remained within normal ranges.</p>

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