Immunohistochemical Expression of Choline Acetyltransferase and Catecholamine-Synthesizing Enzymes in Head-and-Neck and Thoracoabdominal Paragangliomas and Pheochromocytomas

2021 ◽  
Author(s):  
Noriko Kimura ◽  
Kiyoto Shiga ◽  
Ken-ichi Kaneko ◽  
Yutaka Oki ◽  
Chiho Sugisawa ◽  
...  
Keyword(s):  
Head And Neck ◽  
Choline Acetyltransferase ◽  
Immunohistochemical Expression ◽  
Catecholamine Synthesizing Enzymes

Catecholamine-Synthesizing Enzymes Are Expressed in Parasympathetic Head and Neck Paraganglioma Tissue

2015 ◽  
Vol 101 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Thamara E. Osinga ◽  
Esther Korpershoek ◽  
Ronald R. de Krijger ◽  
Michiel N. Kerstens ◽  
Robin P.F. Dullaart ◽  
...  
Keyword(s):  
Head And Neck ◽  
Catecholamine Synthesizing Enzymes ◽  
Head And Neck Paraganglioma

scholarly journals ACE2 Protein Landscape in the Head and Neck Region: The Conundrum of SARS-CoV-2 Infection

Biology ◽  
2020 ◽  
Vol 9 (8) ◽  
pp. 235 ◽  
Author(s):  
Géraldine Descamps ◽  
Laurine Verset ◽  
Anne Trelcat ◽  
Claire Hopkins ◽  
Jérome R. Lechien ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Head And Neck ◽  
Neck Region ◽  
Converting Enzyme ◽  
Upper Aerodigestive Tract ◽  
Immunohistochemical Expression ◽  
Vocal Cords ◽  
Head And Neck Region ◽  
Angiotensin Converting Enzyme 2 ◽  
Histological Location

The coronavirus pandemic raging worldwide since December 2019 is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which invades human cells via the angiotensin-converting enzyme 2 (ACE2) receptor. Although it has already been identified in many organs, ACE2 expression remains largely unknown in the head and neck (HN) sphere. Thus, this study aims to investigate its protein expression in several sites of the upper aerodigestive tract in order to highlight potential routes of infection. We compared ACE2 immunohistochemical expression between 70 paraffin-embedded specimens with two different antibodies and reported the quantified expression in each histological location. Surprisingly, we obtained different results depending on the antibody, an absence of labeling having been observed with a monoclonal antibody raised against the extracellular domain, whereas the polyclonal, against the cytoplasmic part of the protein, revealed enriched ACE2 expression, particularly in sinuses, vocal cords, salivary glands and oral cavity epithelial cells. The interpretation of these discordant results has brought several exciting lines of reflection. In conclusion, this study provides possible routes of entry for the SARS-CoV-2 in HN region and, above all, has led us to encourage caution when studying the ACE2 expression which is currently at the center of all attention.

Immunohistochemical expression of p53 and MDM2 within head and neck squamous cell carcinoma

2006 ◽  
Vol 31 (3) ◽  
pp. 247-247 ◽  
Author(s):  
S. Tandon ◽  
H. Beer ◽  
T.M. Jones ◽  
M. Birchall ◽  
M. Boyd ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
Immunohistochemical Expression

Immunohistochemical expression of MUC4 in different grades of Head and Neck Squamous cell carcinoma

2020 ◽  
pp. 1-14
Author(s):  
Naila Umer ◽  
Nadia Naseem ◽  
Saima Chaudhry
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Tertiary Care ◽  
Oral Pathology ◽  
Neck Squamous Cell Carcinoma ◽  
Urban Setting ◽  
Immunohistochemical Expression ◽  
Normal Epithelium

Abstract Objective: To determine immunohistochemical expression of Mucin 4 in head and neck squamous cell carcinoma and its different histological grades among patients reporting to various tertiary care hospitals in an urban setting. Method: The descriptive study was conducted at the Department of Oral Pathology / Morbid Anatomy and Histopathology, University of Health Sciences, Lahore, Pakistan, from January to July 2017, and comprised cases of head and neck squamous cell carcinoma. Histological diagnosis and grading was done for each case. Haematoxylin and eosin stain followed by immunohistochemistry was done. Relation of Mucin 4 expression with tumour types was explored. SPSS 20 was used for statistical analysis. Result: Of the 63 samples, 40(63.5%) were from male patients. The overall mean age of the patients was 53±3.77 years. Mucin 4 expression was positive in 47(74.6%) cases. Of them, 16(34%) had grade 1 tumour, 28(59.6%) had grade 2 and 3(6.4%) had grade 3 tumour. tumourThere was a significant relation (p=0.03) between tumour grades and intensity of Mucin 4 expression. tumour Conclusion: Upregulation of Mucin 4in tumour tissue with no expression in normal epithelium was found, and loss of Mucin 4 expression with increase in tumour grade was noted. Key Words: Mucin 4, MUC4, Squamous cell carcinoma of head and neck, HNSCC, Immunohistochemistry Continuous...

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