Large Mass Affecting Retroperitoneal Great Vessels: A Rare Presentation of A Cancer of Unknown Primary with Diagnostic Dilemma and Challenged Surgical Intervention

2009 ◽  
Vol 40 (1-2) ◽  
pp. 55-58 ◽  
Author(s):  
Paraskevi Stakia ◽  
Panagiotis Lagos ◽  
Stavros Gourgiotis ◽  
Vasilios D. Tzilalis ◽  
Stavros Aloizos ◽  
...  
Keyword(s):  
Surgical Intervention ◽  
Large Mass ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Rare Presentation ◽  
Diagnostic Dilemma ◽  
Great Vessels

scholarly journals A rare presentation of ovarian fibrothecoma: a diagnosing dilemma

2018 ◽  
Vol 7 (4) ◽  
pp. 1654
Author(s):  
Kalaivani Logesh ◽  
Latha Prasanna
Keyword(s):  
Postmenopausal Woman ◽  
Stromal Cell ◽  
Surgical Intervention ◽  
Pelvic Mass ◽  
Accurate Diagnosis ◽  
Female Gonad ◽  
Rare Presentation ◽  
Ovarian Tumours ◽  
Benign Tumours

Ovarian Fibrothecoma are uncommon tumors of gonadal stromal cell origin accounting for 3-4% of all ovarian tumours. Ovarian fibrothecoma are composed of an admixture of fibrous and the comatous elements. The stromal cell tumors are probably the most inaccurately diagnosed tumor of the female gonad, clinically and histologically. Rarely benign tumours can present with elevated CA125. Here we discuss a rare presentation of Ovarian Fibrothecoma in a 52 years postmenopausal woman with large pelvic mass with ascites and elevated CA125 which we mistook for malignancy. Hence accurate diagnosis is more important before extensive surgical intervention.

scholarly journals Cancer of Unknown Primary: Challenges and Progress in Clinical Management

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 451
Author(s):  
Noemi Laprovitera ◽  
Mattia Riefolo ◽  
Elisa Ambrosini ◽  
Christiane Klec ◽  
Martin Pichler ◽  
...  
Keyword(s):  
Current Knowledge ◽  
Distant Metastases ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Diagnostic Strategies ◽  
Molecular Features ◽  
Tissue Of Origin ◽  
Novel Therapeutic Strategies ◽  
Aggressive Clinical Behavior

Distant metastases are the main cause of cancer-related deaths in patients with advanced tumors. A standard diagnostic workup usually contains the identification of the tissue-of-origin of metastatic tumors, although under certain circumstances, it remains elusive. This disease setting is defined as cancer of unknown primary (CUP). Accounting for approximately 3–5% of all cancer diagnoses, CUPs are characterized by an aggressive clinical behavior and represent a real therapeutic challenge. The lack of determination of a tissue of origin precludes CUP patients from specific evidence-based therapeutic options or access to clinical trial, which significantly impacts their life expectancy. In the era of precision medicine, it is essential to characterize CUP molecular features, including the expression profile of non-coding RNAs, to improve our understanding of CUP biology and identify novel therapeutic strategies. This review article sheds light on this enigmatic disease by summarizing the current knowledge on CUPs focusing on recent discoveries and emerging diagnostic strategies.

scholarly journals Cancer of unknown primary

Medicine ◽  
2017 ◽  
Vol 96 (16) ◽  
pp. e6693 ◽  
Author(s):  
Anne-Kirstine Dyrvig ◽  
Knud Bonnet Yderstræde ◽  
Oke Gerke ◽  
Peter Bjødstrup Jensen ◽  
Søren Hess ◽  
...  
Keyword(s):  
Cancer Of Unknown Primary ◽  
Unknown Primary

scholarly journals Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

2020 ◽  
Author(s):  
Lars Axelsson ◽  
Erik Holmberg ◽  
Jan Nyman ◽  
Anders Högmo ◽  
Helena Sjödin ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Prognostic Factors ◽  
Head And Neck ◽  
Neck Dissection ◽  
Neck Cancer ◽  
Multicenter Study ◽  
Performance Status ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
N Stage

Abstract Introduction Head and neck cancer of unknown primary (HNCUP) is a rare condition whose prognostic factors that are significant for survival vary between studies. No randomized treatment study has been performed thus far, and the optimal treatment is not established. Objective The present study aimed to explore various prognostic factors and compare the two main treatments for HNCUP: neck dissection and (chemo) radiation vs primary (chemo) radiation. Methods A national multicenter study was performed with data from the Swedish Head and Neck Cancer Register (SweHNCR) and from the patients' medical records from 2008 to 2012. Results Two-hundred and sixty HNCUP patients were included. The tumors were HPV-positive in 80%. The overall 5-year survival rate of patients treated with curative intent was 71%. Age (p < 0.001), performance status (p= 0.036), and N stage (p= 0.046) were significant factors for overall survival according to the multivariable analysis. Treatment with neck dissection and (chemo) radiation (122 patients) gave an overall 5-year survival of 73%, and treatment with primary (chemo) radiation (87 patients) gave an overall 5-year survival of 71%, with no significant difference in overall or disease-free survival between the 2 groups. Conclusions Age, performance status, and N stage were significant prognostic factors. Treatment with neck dissection and (chemo) radiation and primary (chemo) radiation gave similar survival outcomes. A randomized treatment study that includes quality of life is needed to establish the optimal treatment.

scholarly journals Family history of cancer in first degree relatives and risk of cancer of unknown primary

2021 ◽  
Author(s):  
Alexander L. R. Grewcock ◽  
Karlijn E. P. E. Hermans ◽  
Matty P. Weijenberg ◽  
Piet A. Brandt ◽  
Caroline Loef ◽  
...  
Keyword(s):  
Family History ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Family History Of Cancer ◽  
First Degree Relatives ◽  
History Of ◽  
Risk Of Cancer ◽  
History Of Cancer

scholarly journals Large Right Atrial Myxoma Masquerading as Malignancy

2021 ◽  
Author(s):  
Bharath V. ◽  
Milind Padmakar Hote
Keyword(s):  
Right Heart Failure ◽  
Large Mass ◽  
Atrial Myxoma ◽  
Right Atrial ◽  
Free Wall ◽  
Right Heart ◽  
Rare Presentation ◽  
Right Atrial Myxoma ◽  
Hard Consistency ◽  
Stony Hard

AbstractA 57-year-old female presented to emergency with features of right heart failure. On evaluation, she was found to have a large mass occupying right atrium (RA) completely and protruding into right ventricle through tricuspid valve. Intraoperatively, mass was seen arising from RA free wall with stony hard consistency. Histopathology revealed it to be myxoma. We present this case for the rare presentation of myxoma masquerading as malignancy.

scholarly journals Cancer of Unknown Primary Presenting as Bone‐Predominant or Lymph Node‐Only Disease: A Clinicopathologic Portrait

2021 ◽  
Author(s):  
Ryan W. Huey ◽  
Brandon G. Smaglo ◽  
Jeannelyn S. Estrella ◽  
Aurelio Matamoros ◽  
Michael J. Overman ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary

scholarly journals Cancer of Unknown Primary in the Molecular Era

2021 ◽  
Author(s):  
Shumei Kato ◽  
Ahmed Alsafar ◽  
Vighnesh Walavalkar ◽  
John Hainsworth ◽  
Razelle Kurzrock
Keyword(s):  
Cancer Of Unknown Primary ◽  
Unknown Primary

scholarly journals A Retrospective Analysis of Cancer of Unknown Primary in Ibaraki Prefectural Central Hospital

2013 ◽  
Vol 24 ◽  
pp. ix38
Author(s):  
F. Fujisawa ◽  
S. Meshihtsuka ◽  
S. Mitsuhashi ◽  
M. Hori ◽  
T. Kaburagi ◽  
...  
Keyword(s):  
Retrospective Analysis ◽  
Cancer Of Unknown Primary ◽  
Unknown Primary ◽  
Central Hospital ◽  
Prefectural Central Hospital
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