Incidence Trends of Gastric Cancer in Southern Iran: Adenocarcinoma and Non-cardia Gastric Cancer Are More Rising Among Younger Ages

Abstract Background Gastric cancer (GC) is still one of the major causes of cancer mortality. Due to health-related transitions, the epidemiology of GC subtypesmaybe changed. These changes may have profound effects on the clinical approaches, and public health management of GC. Iran, as a developing country, has experienced huge demographic and epidemiological transitions during recent decades. We aimed to investigate subtype-specific population-based incidence trends of GC in southern Iran. Methods We used data on GC incidence in southern Iran for 2001–2015. Data preparation and subtype grouping were done based on the ICD-O-3. Trends of age-standardized incidence rate (ASR), truncated ASRs, the incidence rate of early-onset, adenocarcinoma, and cardia GC, and age-gender specific rates were analyzed applying joinpoint regression modeling. Annual percentage change (APC) and its 95%confidence intervals (CI) were estimated. Results Overall APC was estimated at 7.2 for males and 8.7 for females. Estimated APCs for trends of overall GC, and gastric adenocarcinoma were stable for both genders during 2009 to 2015, while the trends of cardia GC were increasing for both genders. Estimated APCs for trends of non-cardia GC wasalso stable. Conclusion Overall trends of incidence of GC in southern Iran have been stable for the last decade. However, significant and different changes in the pattern of GC have occurred.Etiological and prognostic studies are needed in Iran for improvement of the GC management.

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Incidence Trends of Esophageal and Gastric Cancer Subtypes by Race, Ethnicity, and Age in the United States, 1997–2014

Clinical Gastroenterology and Hepatology ◽

10.1016/j.cgh.2018.05.044 ◽

2019 ◽

Vol 17 (3) ◽

pp. 429-439 ◽

Cited By ~ 23

Author(s):

Farhad Islami ◽

Carol E. DeSantis ◽

Ahmedin Jemal

Keyword(s):

United States ◽

Gastric Cancer ◽

The United States ◽

Cancer Subtypes ◽

Incidence Trends ◽

Race Ethnicity

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Is gastric cancer becoming a rare disease? A global assessment of predicted incidence trends to 2035

Gut ◽

10.1136/gutjnl-2019-320234 ◽

2020 ◽

Vol 69 (5) ◽

pp. 823-829 ◽

Cited By ~ 17

Author(s):

Melina Arnold ◽

Jin Young Park ◽

M Constanza Camargo ◽

Nuno Lunet ◽

David Forman ◽

...

Keyword(s):

Gastric Cancer ◽

Rare Disease ◽

Cancer Incidence ◽

Age Groups ◽

Cancer Registries ◽

Global Scale ◽

Incidence Rates ◽

Incidence Trends ◽

High Incidence ◽

Low Incidence

ObjectivesThe incidence of gastric cancer continues to decrease globally, approaching levels that in some populations could define it as a rare disease. To explore this on a wider scale, we predict its future burden in 34 countries with long-standing population-based data.MethodsData on gastric cancer incidence by year of diagnosis, sex and age were extracted for 92 cancer registries in 34 countries included in Cancer Incidence in Five Continents Plus. Numbers of new cases and age-standardised incidence rates (ASR per 100 000) were predicted up to 2035 by fitting and extrapolating age–period–cohort models.ResultsOverall gastric cancer incidence rates are predicted to continue falling in the future in the majority of countries, including high-incidence countries such as Japan (ASR 36 in 2010 vs ASR 30 in 2035) but also low-incidence countries such as Australia (ASR 5.1 in 2010 vs ASR 4.6 in 2035). A total of 16 countries are predicted to fall below the rare disease threshold (defined as 6 per 100 000 person-years) by 2035, while the number of newly diagnosed cases remains high and is predicted to continue growing. In contrast, incidence increases were seen in younger age groups (below age 50 years) in both low-incidence and high-incidence populations.ConclusionsWhile gastric cancer is predicted to become a rare disease in a growing number of countries, incidence levels remain high in some regions, and increasing risks have been observed in younger generations. The predicted growing number of new cases highlights that gastric cancer remains a major challenge to public health on a global scale.

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Recent incidence trends and sociodemographic features of oesophageal and gastric cancer types in an English region

Alimentary Pharmacology & Therapeutics ◽

10.1111/j.1365-2036.2009.04100.x ◽

2009 ◽

Vol 30 (8) ◽

pp. 873-880 ◽

Cited By ~ 12

Author(s):

C. GAJPERIA ◽

J. M. BARBIERE ◽

D. GREENBERG ◽

K. WRIGHT ◽

G. LYRATZOPOULOS

Keyword(s):

Gastric Cancer ◽

Incidence Trends ◽

Cancer Types

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Current substance use in patients with gastric cancer in Southern Iran

Journal of Cancer Research and Therapeutics ◽

10.4103/0973-1482.29828 ◽

2006 ◽

Vol 2 (4) ◽

pp. 182 ◽

Cited By ~ 3

Author(s):

ST Heydari ◽

D Mehrabani ◽

SJ Shamsina ◽

J Ahmadi ◽

SaberiM Firouzi ◽

...

Keyword(s):

Gastric Cancer ◽

Substance Use ◽

Southern Iran

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Incidence trends and mortality rates of gastric cancer in Israel

Gastric Cancer ◽

10.1007/s10120-012-0155-4 ◽

2012 ◽

Vol 16 (2) ◽

pp. 121-125 ◽

Cited By ~ 8

Author(s):

Ron Lavy ◽

Andronik Kapiev ◽

Natan Poluksht ◽

Ariel Halevy ◽

Lital Keinan-Boker

Keyword(s):

Gastric Cancer ◽

Mortality Rates ◽

Incidence Trends

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Ultrastructural Cytochemical Study of Human Gastric Cancer: Observation of AKP ase,ACP ase,G6P ase,TPP ase and CO ase

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158819 ◽

1990 ◽

Vol 48 (3) ◽

pp. 254-255

Author(s):

Dong Yuming ◽

Yang Guanglin ◽

Du Wei Dong ◽

Xu Ai Liam

Keyword(s):

Gastric Cancer ◽

Gastric Epithelium ◽

Human Gastric Cancer ◽

Electron Microscopic ◽

Cytochemical Study ◽

Electron Microscopic Cytochemistry ◽

Cytochemical Reaction ◽

Set Up ◽

Cancer Tissues ◽

Cytochemical Technique

The activities and distributions of AKPase ,ACPase,G6Pase,TPPase and COase in human normal gastric mucosa and gastric cancer tissues were studied histochemically at light microscopic level. These enzymes are the marker enzymes of cell membrane lysosome endoplasmic reticulum, Golgi apparatus and mitochondrion objectively. On the basis of the research we set up a special ultrastructural cytochemical technique and first researched into gastric cancer domesticly. Ultrastructural cytochemistry is also called electron microscopic cytochemistry. This new technique possesses both the sensitivity of cytochemical reaction andi the high resolution of electron microscope. It is characterized by direct observation,exact localization and the combination morphology with function.The distributions of AKPase,ACPase,G6Pase,TPPase and COase in 14 cases of gastric cancer and 1 case of gastric Denign lesion were studied ultrastructurally. The results showed: 1. normal gastric epithelium had no AKPase reaction. The reaction of ACPase,G6Pase,TPPase and Coase were found in the corresponding organella, which were consistent with their function.

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Ultrastructural Localization Study of Carcinoembryonic Antigen (CEA) in Gastric Cancer: Immunoelectron Microscopic Observation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100158807 ◽

1990 ◽

Vol 48 (3) ◽

pp. 252-253

Author(s):

Dong Yuming ◽

Yang Guanglin ◽

Wu Jifeng ◽

Chen Xiaolin

Keyword(s):

Gastric Cancer ◽

Intestinal Metaplasia ◽

Cancer Cells ◽

Microscopic Observation ◽

Biological Significance ◽

Ultrastructural Localization ◽

Mucinous Carcinoma ◽

Surface Glycoprotein ◽

Tubular Adenocarcinoma ◽

Pap Method

On the basis of light microscopic observation, the ultrastructural localization of CEA in gastric cancer was studied by immunoelectron microscopic technique. The distribution of CEA in gastric cancer and its biological significance and the mechanism of abnormal distribution of CEA were further discussed.Among 104 surgically resected specimens of gastric cancer with PAP method at light microscopic level, the incidence of CEA(+) was 85.58%. All of mucinous carcinoma exhibited CEA(+). In tubular adenocarcinoma the incidence of CEA(+) showed a tendency to rising with the increase of degree of differentiation. In normal epithelia and intestinal metaplasia CEA was faintly present and was found only in the luminal surface. The CEA staining patterns in cancer cells were of three types--- cytoplasmic, membranous and weak reactive type. The ultrastructural localization of CEA in 14 cases of gastric cancer was studied by immunoelectron microscopic technique.There was a little or no CEA in the microvilli of normal epithelia. In intestinal metaplasia CEA was found on the microvilli of absorptive cells and among the mucus particles of goblet cells. In gastric cancer CEA was also distributed on the lateral and basal surface or even over the entire surface of cancer cells and lost their polarity completely. Many studies had proved that the alterations in surface glycoprotein were characteristic changes of tumor cells. The antigenic determinant of CEA was glycoprotein, so the alterations of tumor-associated surface glycoprotein opened up a new way for the diagnosis of tumors.

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