A Comprehensive Review on the Role of Genetic Factors in the Pathogenesis of Migraine

Neuromyelitis optica spectrum disorders (NMOSD) comprise a variety of disorders being described by optic neuritis and myelitis. This disorder is mostly observed in sporadic form, yet 3% of cases are familial NMO. Different series of familial NMO cases have been reported up to now, with some of them being associated with certain HLA haplotypes. Assessment of HLA allele and haplotypes has also revealed association between some alleles within HLA-DRB1 or other loci and sporadic NMO. More recently, genome-wide SNP arrays have shown some susceptibility loci for NMO. In the current manuscript, we review available information about the role of genetic factors in NMO.

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Role of miRNA gene variants in the susceptibility and pharmacogenetics of colorectal cancer

Pharmacogenomics ◽

10.2217/pgs-2020-0159 ◽

2021 ◽

Vol 22 (5) ◽

pp. 303-318

Author(s):

Amirsaeed Sabeti Aghabozorgi ◽

Samaneh Sharif ◽

Reza Jafarzadeh-Esfehani ◽

Saba Vakili ◽

Mohammad Reza Abbaszadegan

Keyword(s):

Colorectal Cancer ◽

Genetic Factors ◽

Expression Patterns ◽

Mirna Gene ◽

Cancer Biomarkers ◽

Clinical Parameters ◽

Comprehensive Review ◽

Factors Associated ◽

Cancer Pathology

Colorectal cancer (CRC) is one of the most significant challenges in the field of cancer pathology. miRNAs are among the genetic factors associated with the disease. Although many studies have reviewed the expression patterns of various miRNAs in CRC, few studies have focused on different variants of miRNA. In the present review, miRNA variants have been categorized into three subgroups, including miRNA variants that predict susceptibility to CRC, miRNA variants that predict the clinical parameters of CRC and finally, miRNA variants that predict the pharmacological aspects of CRC. Moreover, a comprehensive review of potentially functional miRNA-associated SNPs as well as their importance as candidate cancer biomarkers are discussed.

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Vitamin D in trichology: a comprehensive review of the role of vitamin D and its receptor in hair and scalp disorders

Giornale Italiano di Dermatologia e Venereologia ◽

10.23736/s0392-0488.19.06305-3 ◽

2020 ◽

Vol 155 (2) ◽

Author(s):

Giovanni Damiani ◽

Rosalynn Conic ◽

Gloria Orlando ◽

Anna Zampetti ◽

Elena Marinello ◽

...

Keyword(s):

Vitamin D ◽

Comprehensive Review

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Epigenetic factors and molecular markers of the risk of early pregnancy losses

GYNECOLOGY ◽

10.26442/20795696.2019.4.190523 ◽

2019 ◽

Vol 21 (3) ◽

pp. 9-16

Author(s):

Nataly I Frolova ◽

Tatiana E Belokrinitskaya

Keyword(s):

Early Pregnancy ◽

Genetic Factors ◽

Molecular Genetic ◽

Pregnancy Complication ◽

Common Complication ◽

Epigenetic Factors ◽

Genetic Determination ◽

Periconceptional Period ◽

Combined Impact

Background. Miscarriage is a common complication in early pregnancy. Current studies have shown a higher prevalence of miscarriage, ranging from 10 to 20%. The review is devoted to modern concepts of etiology and pathogenesis of early pregnancy losses. Aim. Assess the role of epigenetic factors and molecular-genetic markers in the pathogenesis and prediction of early pregnancy losses Materials and methods. In order to write this review domestic and foreign publications were searched in Russian and international search systems (PubMed, eLibrary, etc.) for the last 10-15 years. Relevant articles from the peer-reviewed literature and clinical practice guidelines were included. Results. Many recent studies have proved the contribution of various epigenetic factors to the pathogenesis of spontaneous miscarriages, and the molecular-genetic determination such kinds of pregnancy complication has been confirmed. Conclusion. The miscarriage in early gestation is driven by combined impact of epigenetic and molecular-genetic factors, as well as the presence of intergenic interactions. It is may lead to deterioration of physiological functions, and maternal pathologenic pathways could be changed as during her periconceptional period as so during the pregnancy.

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Role of Genetic Factors in the Causation of Non-Syndromic Hearing Loss (NSHL) in Indian Population

Archives of Clinical and Biomedical Research ◽

10.26502/acbr.50170143 ◽

2020 ◽

Vol 04 (06) ◽

Author(s):

Shehnaz Sultana ◽

Pratibha Nallari ◽

Venkateshwari Ananthapur

Keyword(s):

Hearing Loss ◽

Indian Population ◽

Genetic Factors ◽

Syndromic Hearing Loss

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Role of genetic factors in the development of hypertension in young patients with metabolic syndrome

Spravočnik vrača obŝej praktiki (Journal of Family Medicine) ◽

10.33920/med-10-2004-03 ◽

2020 ◽

pp. 23-32

Author(s):

Elena Korneeva ◽

Mikhail Voevoda ◽

Sergey Semaev ◽

Vladimir Maksimov

Keyword(s):

Metabolic Syndrome ◽

High Risk ◽

Arterial Hypertension ◽

Genetic Factors ◽

Young Patients ◽

Integrin Αiibβ3 ◽

Ace Gene ◽

The Metabolic Syndrome

Results of the study related to polymorphism of ACE gene (rs1799752)‎, integrin αIIbβ3, and CSK gene (rs1378942) influencing development of arterial hypertension in young patients with metabolic syndrome are presented. Hypertension as a component of the metabolic syndrome was detected in 15.0% of young patients. Prevalence of mutant alleles of the studied genes among the examined patients was quite high, so homozygous DD genotype was found in 21.6%, and mutant D allele of the ACE gene in 47.4%. A high risk of hypertension in patients with MS was detected in carriers of the T allele of the CSK (rs1378942) gene – 54.8%, which was most often observed in a combination of polymorphic ACE and CSK gene loci (p = 0.0053).

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