To Compare and Evaluate Laryngeal Changes in Patients with Dysphonia in Laryngopharyngeal Reflux (LPR) before and after Treatment with Proton Pump Inhibitors (PPI) and Prokinetic Drugs

2021 ◽  
Author(s):  
Shalini Jain ◽  
Sarita Gupta ◽  
W. V. B. S. Ramalingam
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux ◽  
Prokinetic Drugs ◽  
Before And After

scholarly journals Duodenal Dysbiosis and Relation to the Efficacy of Proton Pump Inhibitors in Functional Dyspepsia

2021 ◽  
Vol 22 (24) ◽  
pp. 13609
Author(s):  
Lucas Wauters ◽  
Raúl Y. Tito ◽  
Matthias Ceulemans ◽  
Maarten Lambaerts ◽  
Alison Accarie ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Potential Role ◽  
Short Term ◽  
Beneficial Effects ◽  
Rrna Sequencing ◽  
Before And After

Proton pump inhibitors (PPI) may improve symptoms in functional dyspepsia (FD) through duodenal eosinophil-reducing effects. However, the contribution of the microbiome to FD symptoms and its interaction with PPI remains elusive. Aseptic duodenal brushings and biopsies were performed before and after PPI intake (4 weeks Pantoprazole 40 mg daily, FD-starters and controls) or withdrawal (2 months, FD-stoppers) for 16S-rRNA sequencing. Between- and within-group changes in genera or diversity and associations with symptoms or duodenal factors were analyzed. In total, 30 controls, 28 FD-starters and 19 FD-stoppers were followed. Mucus-associated Porphyromonas was lower in FD-starters vs. controls and correlated with symptoms in FD and duodenal eosinophils in both groups, while Streptococcus correlated with eosinophils in controls. Although clinical and eosinophil-reducing effects of PPI therapy were unrelated to microbiota changes in FD-starters, increased Streptococcus was associated with duodenal PPI effects in controls and remained higher despite withdrawal of long-term PPI therapy in FD-stoppers. Thus, duodenal microbiome analysis demonstrated differential mucus-associated genera, with a potential role of Porphyromonas in FD pathophysiology. While beneficial effects of short-term PPI therapy were not associated with microbial changes in FD-starters, increased Streptococcus and its association with PPIeffects in controls suggest a role for duodenal dysbiosis after long-term PPI therapy.

scholarly journals Depression, Hematologic Parameters, and Blood Levels of Vitamin B12 in Patients With Laryngopharyngeal Reflux Under Use of Proton Pump Inhibitors

2019 ◽  
Vol 12 ◽  
pp. 117955061982868 ◽  
Author(s):  
Rebecca Heidrich Thoen Ribeiro ◽  
Fernando Ambros Ribeiro ◽  
Romeu Paulo Martins Silva ◽  
Miguel Júnior Sordi Bortolini ◽  
Mario da Silva Garrote-Filho ◽  
...  
Keyword(s):  
Proton Pump ◽  
Complete Blood Count ◽  
Laryngopharyngeal Reflux ◽  
Epidemiologic Studies ◽  
Blood Levels ◽  
Vitamin B ◽  
Mean Corpuscular Hemoglobin ◽  
Before And After ◽  
A Prospective Study ◽  
Study Participants

Objective: The objective of this study was to evaluate and correlate hematologic indices, vitamin B12 levels, and depression in patients with suspected laryngopharyngeal reflux (LPR) treated with proton pump inhibitor (PPI). Methods: This was a prospective study with a population (n = 23) consisted of patients with suspected LPR and treated with 2 daily doses of Omeprazole 40 mg (80 mg or full dose). The study volunteers performed a complete blood count and vitamin B12 dosage before and after 3 and 6 months of treatment, as well as depression screening using the Center of Epidemiologic Studies-Depression (CES-D) questionnaire before and after 6 months of treatment. Scores greater than 16 were considered as suggestive of depression. Results: The mean score on the CES-D scale of study participants at baseline significantly decreased after 6 months of treatment. A significant decrease was observed in the red blood cells count (RBC) after 6 months in relation to 3 months. Significant increases in mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were observed from 3 months to 6 months in this study. Vitamin B12 levels increased significantly between baseline and after 6 months of treatment. Conclusion: Decreased scores on the CES-D scale were associated with increased MCV values, with no association with vitamin B12 levels. However, vitamin B12 levels also increased significantly after 6 months of treatment with PPI.

Presumed laryngo-pharyngeal reflux: investigate or treat?

2000 ◽  
Vol 114 (6) ◽  
pp. 441-447 ◽  
Author(s):  
Alan G. Fraser ◽  
Randall P. Morton ◽  
Jeanette Gillibrand
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux ◽  
Ph Monitoring ◽  
Rank Correlation ◽  
Clinical Findings ◽  
Response To Treatment ◽  
Spearman Rank Correlation ◽  
Clinical Criteria ◽  
Symptom Response

A review of a combined gastroenterology and laryngology clinic was conducted to determine the effectiveness of treatment and the predictive value of clinical findings and investigations.Data were collected prospectively. Investigations were performed according to clinical criteria. Patients with symptoms suspected to be due to laryngopharyngeal reflux (based on a positive oesophageal pH test and/or changes on videolaryngoscopy consistent with posterior laryngitis) were treated with omeprazole for at least two to three months.There were 87 patients; the most common symptoms were cough (38 per cent) and hoarseness (36 per cent); 77 per cent had some symptoms suggestive of gastro-oesophageal reflux. Sixty-seven patients were given omeprazole. A good response to laryngo-pharyngeal symptoms was seen in 37 patients (55 per cent). The presence of reflux symptoms was not a predictor of a good response. Increasing severity of oesophageal acid exposure over the 24 hours of pH testing was associated with a better symptom response (Spearman rank correlation, p = 0.01). Posterior laryngitis was not associated with the response to treatment, although there was a trend towards an association between improvement in laryngitis (after treatment) and improvement in symptoms (p = 0.08).The response to proton pump inhibitors was lower than other published results. Oesophageal pH monitoring may have a role in predicting which patients will respond to proton pump inhibitors. This study does not support the decision to treat with anti-secretory therapy, based only on the presence of posterior laryngitis.

scholarly journals Gut Microbiota Composition Before and After Use of Proton Pump Inhibitors

2018 ◽  
Vol 63 (11) ◽  
pp. 2940-2949 ◽  
Author(s):  
Mariko Hojo ◽  
Takashi Asahara ◽  
Akihito Nagahara ◽  
Tsutomu Takeda ◽  
Kohei Matsumoto ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Microbiota Composition ◽  
Before And After ◽  
Gut Microbiota Composition

scholarly journals Clinical Manifestations and Role of Proton Pump Inhibitors in the Management of Laryngopharyngeal Reflux

2011 ◽  
Vol 63 (2) ◽  
pp. 182-189 ◽  
Author(s):  
Suhail Amin Patigaroo ◽  
S. F. Hashmi ◽  
Syed Abrar Hasan ◽  
M. R. Ajmal ◽  
Nazia Mehfooz
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Laryngopharyngeal Reflux ◽  
Clinical Manifestations

scholarly journals Postthyroidectomy Throat Pain and Swallowing: Do Proton Pump Inhibitors Make a Difference?

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Faisal Zawawi ◽  
Keith Richardson ◽  
Rickul Varshney ◽  
Jonathan Young ◽  
Alex M. Mlynarek ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Thyroid Surgery ◽  
Laryngopharyngeal Reflux ◽  
Clinic Visit ◽  
Control Group ◽  
Study Group ◽  
Pain Level ◽  
Throat Pain ◽  
Average Pain

Objectives. Following thyroid surgery patients complain from swallowing disability and throat pain resembling symptoms of laryngopharyngeal reflux (LPR). The purpose of this study is to assess whether proton pump inhibitors (PPIs) given to patients in the first postoperative week relieve the swallowing disability and throat pain complaints. Materials and Methods. A questionnaire was given to 523 patients who had thyroid surgery between October 2010 and August 2011. In the first postoperative clinic visit each patient was approached to fill out a questionnaire. 208 patients met criteria, 100 of which were on PPIs (study group) and 108 were not on PPIs (control group). Results. When comparing the study group to the control group, the average pain level was 2.57 compared to 3.9 during the first postoperative week, and 1.27 compared to 2.41 at day 7 ( value = 0.001). Swallowing disability was also lower in the study group when compared to the control group, 1.87 and 3.12, respectively, during the first postoperative week and 0.87 and 1.76, respectively, at day 7 ( value = 0.007). Conclusion. Patients treated with PPIs had less pain and swallowing disability in the first week following thyroid surgery, when compared to patients not treated with PPIs.

scholarly journals Investigation on Intervention Effects of Applying Proton Pump Inhibitors in Inpatients

2019 ◽  
Author(s):  
Guotong Qing ◽  
Jian Wu ◽  
Runfong Wei ◽  
Di Wu ◽  
Yipping Gou ◽  
...  
Keyword(s):  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Age Distribution ◽  
Information Management System ◽  
Hospitalized Patients ◽  
Utilization Rate ◽  
Coincidence Rate ◽  
Cross Sectional ◽  
Clinical Pharmacists ◽  
Before And After

Abstract Background. To investigate the intervention effect of clinical pharmacists on irrational use of proton pump inhibitors (PPIs) in clinicians. Methods. A cross-sectional study was used to through the hospital information management system survey, before intervention (July 15th, 2016, Aug 15th, 2016 and Sep 15th 2016) and dry prognosis (July 15th, 2017, Aug 15th, 2017 and Sep 15th, 2017) all the use of PPIs inpatients related information. According to the guidelines of "drug instructions" and "experts on stress ulcer prevention and treatment experts", the standard of drug use was formulated, and the use of PPIs before and after intervention was evaluated and analyzed in accordance with the standard, and the results of intervention were evaluated. Results. The total number of hospitalized patients surveyed before the intervention was 1,693, the average utilization rate of proton pump inhibitors was 27.05% and the coincidence rate was 52.40%. The total number of hospitalized patients investigated after the intervention was 2,095, the average utilization rate of proton pump inhibitors was 8.54%, and the coincidence rate was 68.16%. Before and after the intervention, there was no difference in gender ratio and age distribution, the decrease of the utilization rate and the improvements of the qualified rate after intervention were statistically significant.Conclusion. According to the standards of PPIs, clinical pharmacists strictly implement the special prescription review system and other intervention measures, which can significantly improve the level of PPIs rational clinical medication.

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