Quercetin decreases sterile inflammation proteins NLRP3 and caspase 1 in clone-9 cell line damaged by hydrogen peroxide

2021 ◽  
Author(s):  
Erhan Sahin ◽  
Sinem Dabagoglu Psav ◽  
Varol Sahinturk ◽  
Ayse Tansu Koparal
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Line ◽  
Sterile Inflammation ◽  
Caspase 1

scholarly journals Protective effect of vanillic acid in hydrogen peroxide-induced oxidative stress in D.Mel-2 cell line

2020 ◽  
Author(s):  
Shagufta Taqvi ◽  
Eijaz Ahmed Bhat ◽  
Nasreena Sajjad ◽  
Jamal S.M. Sabir ◽  
Aleem Qureshi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Protective Effect ◽  
Cell Line ◽  
Vanillic Acid

scholarly journals Resveratrol Protects C6 Astrocyte Cell Line against Hydrogen Peroxide-Induced Oxidative Stress through Heme Oxygenase 1

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64372 ◽  
Author(s):  
André Quincozes-Santos ◽  
Larissa Daniele Bobermin ◽  
Alexandra Latini ◽  
Moacir Wajner ◽  
Diogo Onofre Souza ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Peroxide ◽  
Cell Line ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1

Inhibition of cellular proliferation and enhancement of hydrogen peroxide production in fibrosarcoma cell line by weak radio frequency magnetic fields

2014 ◽  
Vol 35 (8) ◽  
pp. 598-602 ◽  
Author(s):  
Pablo R. Castello ◽  
Iain Hill ◽  
Frank Sivo ◽  
Lucas Portelli ◽  
Frank Barnes ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Magnetic Fields ◽  
Radio Frequency ◽  
Cell Line ◽  
Cellular Proliferation ◽  
Hydrogen Peroxide Production ◽  
Fibrosarcoma Cell

Formation of hydrogen peroxide in cell culture media by apple polyphenols and its effect on antioxidant biomarkers in the colon cell line HT-29

2009 ◽  
Vol 53 (10) ◽  
pp. 1226-1236 ◽  
Author(s):  
Phillip Bellion ◽  
Melanie Olk ◽  
Frank Will ◽  
Helmut Dietrich ◽  
Matthias Baum ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Culture ◽  
Cell Line ◽  
Culture Media ◽  
Cell Culture Media ◽  
Colon Cell ◽  
Colon Cell Line ◽  
Ht 29

Over IFI16 expression increased inflammation in Hepatitis B Virus-Associated Glomerulonephritis by Regulating Caspase-1 and IL-1 ß

2020 ◽  
Author(s):  
zhaoqing zeng ◽  
yuyang li ◽  
jinhong yu ◽  
jing liu ◽  
shijun chen ◽  
...  
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Cell Line ◽  
Renal Damage ◽  
Hbv Infection ◽  
Inflammatory Factors ◽  
Inflammasome Activation ◽  
Caspase 1 ◽  
B Virus

Abstract Aims & background: IFI16 plays an important role in innate immunity against invasive microbial infection by sensing double-stranded DNA viruses due to caspase-1-dependent inflammasome activation and subsequent maturation and secretion of IL-1β. However, the role of IFI16 in regulating the immune response to viruses in vivo and in vitro, especially in sensing hepatitis B virus (HBV), has not been examined. We hypothesized that the expression of IFI16 increases corresponding to HBV-mediated inflammation in patients with hepatitis B virus associated glomerulonephritis (HBV-GN), a condition which activates inflammatory mechanisms and causes renal damage. To test this hypothesis, we therefore analyzed the expression of IFI16 and inflammatory factors in HBV-GN tissues and cell lines relative to the inflammatory response to HBV infection. Methods: A total 75 patients with chronic nephritis(CN) including 50 with HBV-GN and 25 with chronic glomerulonephritis (CCN) involved in this study. Each CN patient received renal biopsy, and immunohistochemistry(IHC) was used to detect the expression of IFI16 and inflammatory factors Caspase-1 and IL-1β in the biopsy specimens. Following IFI16 was transfected in HBV-infected and HBV-uninfected human glomerular mesangial (HGM) cell line and HEK-293T cell line, expression of Caspase-1 and IL-1β were detected by Western blot and qRT- PCR. Results: IFI16 expression in HBV-GN biopsies (80.0%) was significantly higher than in CGN (24.0%) and positively correlated with caspase-1 and IL-1𝛽 expression in HBV-GN. In vitro, over expression IFI16 increased caspase-1 and IL-1𝛽 expression in HBV -infected HGM and HEK-293T. Conclusions: The elevation of IFI16 during HBV infection or replication may contribute to renal damage due to inflammation, thus providing a putative therapeutic target and a new avenue for researching the pathogenesis of HBV-GN.

scholarly journals Hydrogen peroxide induces expression and activation of AMP-activated protein kinase in a dental pulp cell line

2008 ◽  
Vol 41 (3) ◽  
pp. 197-203 ◽  
Author(s):  
Y. Fukuyama ◽  
K. Ohta ◽  
R. Okoshi ◽  
H. Kizaki ◽  
K. Nakagawa
Keyword(s):  
Hydrogen Peroxide ◽  
Protein Kinase ◽  
Cell Line ◽  
Dental Pulp ◽  
Pulp Cell ◽  
Dental Pulp Cell ◽  
Amp Activated Protein Kinase

scholarly journals The Role of NLRP3 Inflammasome Activities in Bone Diseases and Vascular Calcification

Inflammation ◽  
2020 ◽  
Author(s):  
Chenyang Yu ◽  
Caihua Zhang ◽  
Zhihui Kuang ◽  
Qiang Zheng
Keyword(s):  
Vascular Calcification ◽  
Nlrp3 Inflammasome ◽  
Periodontal Diseases ◽  
Bone Destruction ◽  
Bone Diseases ◽  
Sterile Inflammation ◽  
Inflammatory Factors ◽  
Bone Homeostasis ◽  
Caspase 1

Abstract Continuous stimulation of inflammation is harmful to tissues of an organism. Inflammatory mediators not only have an effect on metabolic and inflammatory bone diseases but also have an adverse effect on certain genetic and periodontal diseases associated with bone destruction. Inflammatory factors promote vascular calcification in various diseases. Vascular calcification is a pathological process similar to bone development, and vascular diseases play an important role in the loss of bone homeostasis. The NLRP3 inflammasome is an essential component of the natural immune system. It can recognize pathogen-related molecular patterns or host-derived dangerous signaling molecules, recruit, and activate the pro-inflammatory protease caspase-1. Activated caspase-1 cleaves the precursors of IL-1β and IL-18 to produce corresponding mature cytokines or recognizes and cleaves GSDMD to mediate cell pyroptosis. In this review, we discuss the role of NLRP3 inflammasome in bone diseases and vascular calcification caused by sterile or non-sterile inflammation and explore potential treatments to prevent bone loss.

Superoxide-hydrogen peroxide imbalance differentially modulates the keratinocytes cell line (HaCaT) oxidative metabolism via Keap1-Nrf2 redox signaling pathway

2019 ◽  
Vol 46 (6) ◽  
pp. 5785-5793 ◽  
Author(s):  
Micheli Lamberti Jobim ◽  
Verônica Farina Azzolin ◽  
Charles Elias Assmann ◽  
Vera Maria Melchiors Morsch ◽  
Ivana Beatrice Mânica da Cruz ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Line ◽  
Signaling Pathway ◽  
Oxidative Metabolism ◽  
Redox Signaling

Antiproliferative Activity ofLarrea Divaricata Cav.on Lymphoma Cell Line: Participation of Hydrogen Peroxide in Its Action

2009 ◽  
Vol 28 (1) ◽  
pp. 13-22 ◽  
Author(s):  
Roberto Davicino ◽  
Maria Gabriela Manuele ◽  
Sebastian Turner ◽  
Graciela Ferraro ◽  
Claudia Anesini
Keyword(s):  
Hydrogen Peroxide ◽  
Cell Line ◽  
Antiproliferative Activity ◽  
Lymphoma Cell ◽  
Lymphoma Cell Line
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