Quality by Design Methodology for Development and Scale-up of Batch Mixing Processes

2008 ◽  
Vol 3 (4) ◽  
pp. 258-270 ◽  
Author(s):  
Patricia M. Portillo ◽  
Marianthi Ierapetritou ◽  
Silvina Tomassone ◽  
Christine Mc Dade ◽  
Donald Clancy ◽  
...  
2019 ◽  
Vol 54 (1) ◽  
pp. 96-111
Author(s):  
Guilherme Fowler A. Monteiro

Purpose This paper aims to conduct an extensive review and advances a framework for the literature of high-growth firms (HGFs) and scale-ups. Design/methodology/approach This paper takes the form of a literature review. Findings The author makes three specific contributions. First, he presents a broad review of high growth in firms, shedding light on the different levels of analysis. Second, he advances a characterization of scale-up companies to enable a better basis for discussion. Finally, he identifies gaps in the existing literature and suggest paths for future research. Originality/value The interest in HGFs and those referred to as scale-ups has increased considerably in recent years. Despite this trend, existing studies still have conceptual divergences and a gap separating theoretical inputs from the actual experiences of entrepreneurs.


2018 ◽  
Vol 46 (4) ◽  
pp. 21-27 ◽  
Author(s):  
Vladyslav Biloshapka ◽  
Oleksiy Osiyevskyy

Purpose Defines clear steps for growth planning that support answers to the crucial question: How and where are you planning to scale up the business and what talent do you need to implement this? Design/methodology/approach As the “Business model value matrix” shows, having ‘happy customers’ is only one determinant of a business model’s success. The other essential block of diagnostic questions deals with the current state and prospects of the firm’s growth. Findings We found that companies that have found ways to keep their business models in a winner’s state can provide clear, evidence-based answers to questions about growth opportunities and risks, while their less successful peers have difficulty addressing the issues. Continuous collecting and analyzing of this information allows successful companies to embrace the strategy-as-learning model of development, built around active learning and proactive adjustment to evolving environment. Practical implications To develop a strategy for moving to and sustaining the Winner state, managers must clearly articulate and test a set of hypotheses about the mechanisms of their company’s growth. The first step on this path is related to obtaining a clear view on the factors that underpin the current financial performance. Originality/value High-performance cultures make sure that each manager has the clear answers to the questions of value, growth and digitization in order to learn, experiment and implement the company business model agenda. The unproductive cultures, on the other hand, are sustained by managerial teams that usually do not have the answers to these crucial questions, but are very good at political games.


2017 ◽  
Vol 53 ◽  
pp. 56-66 ◽  
Author(s):  
Annett Lomtscher ◽  
Karin Jobst ◽  
Stefan Fogel ◽  
Kay Rostalski ◽  
Silke Stempin ◽  
...  

2014 ◽  
Vol 15 (3) ◽  
pp. 665-693 ◽  
Author(s):  
Glenn A. Van Buskirk ◽  
Satish Asotra ◽  
Christopher Balducci ◽  
Prabir Basu ◽  
Gerald DiDonato ◽  
...  

2002 ◽  
Vol 5 (2) ◽  
Author(s):  
C. A. Martín ◽  
R. J. Brandi ◽  
O. M. Alfano ◽  
A. E. Cassano

AbstractThis paper presents the most important technical tools that are needed for designing homogeneous photoreactors using computer simulation of a rigorous mathematical description of the reactor performance. Employing intrinsic reaction kinetic models and parameters derived from properly analyzed laboratory information, it is shown that is possible to scale up reactors with no additional information and without resorting to empirically adjusted correcting factors. The method is illustrated with two processes of degradation of organic pollutants as typical applications of the newly developed Advanced Oxidation Technologies. Two reactors, having pilot plant sizes, are modeled to show the proposed approach. Predictions from the models are compared with experimental data obtaining reasonable good results. They provide confidence on mathematical modeling as a design methodology for homogeneous photochemical reactors.


1988 ◽  
Vol 14 (6) ◽  
pp. 739-747 ◽  
Author(s):  
Masayuki Horio ◽  
Mamoru Ishida ◽  
Maki Takada ◽  
Norichika Tanaka

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