Topoisomerase IIβ Binding Protein 1 c.*229C>T (rs115160714) Gene Polymorphism and Endometrial Cancer Risk

Abstract Background: Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.Methods: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi-square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis. Results: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR = 1.46, 95% CI = 1.04 – 2.06, p = 0.028; OR = 8.43, 95% CI = 1.05 – 67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.Conclusion: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.

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Plasma Adiponectin Levels and Endometrial Cancer Risk in Pre- and Postmenopausal Women

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jc.2006-1371 ◽

2007 ◽

Vol 92 (1) ◽

pp. 255-263 ◽

Cited By ~ 129

Author(s):

Anne E. Cust ◽

Rudolf Kaaks ◽

Christine Friedenreich ◽

Fabrice Bonnet ◽

Martine Laville ◽

...

Keyword(s):

Risk Factors ◽

Endometrial Cancer ◽

Cancer Risk ◽

Postmenopausal Women ◽

Binding Protein ◽

Inverse Association ◽

Endometrial Cancer Risk ◽

Plasma Adiponectin ◽

Igf Binding ◽

Igf Binding Protein

Abstract Background: Adiponectin, an adipocytokine secreted by adipose tissue, is decreased in obesity, insulin resistance, type 2 diabetes, and polycystic ovary syndrome, all of which are well-established risk factors for endometrial cancer. Methods: We conducted a case-control study nested within the European Prospective Investigation into Cancer and Nutrition to examine the relation between prediagnostic plasma adiponectin levels and endometrial cancer risk. Among pre- and postmenopausal women who were not currently using exogenous hormones, 284 women developed incident endometrial cancer during an average of 5.1 yr of follow-up. Using risk set sampling, 548 control subjects were selected, matched on center, age, menopausal status, phase of menstrual cycle, time of blood draw, and fasting status. Conditional logistic regression models were used to estimate relative risks and 95% confidence intervals. Results: Adiponectin levels were inversely associated with endometrial cancer risk [body mass index-adjusted relative risk for the top vs. bottom quartile = 0.56 (95% confidence interval 0.36–0.86), Ptrend = 0.006]. There was evidence of a stronger inverse association among obese women than among nonobese women (Pheterogeneity = 0.03). The inverse association also appeared stronger for women who were postmenopausal or perimenopausal than premenopausal at baseline, but this was not statistically significantly heterogeneous (Pheterogeneity = 0.51). The association remained statistically significant after separate adjustment for other obesity-related physiological risk factors such as C-peptide, IGF binding protein-1, IGF binding protein-2, SHBG, estrone, or free testosterone but only marginally statistically significant after simultaneous adjustment for these factors. Conclusions: High circulating adiponectin levels are associated with reduced endometrial cancer risk, largely independent of other obesity-related risk factors.

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Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk

Cancer Cell International ◽

10.1186/s12935-020-01646-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Yimin Cheng ◽

Liting Yang ◽

Guangyao Shi ◽

Peng Chen ◽

Liang Li ◽

...

Keyword(s):

Endometrial Cancer ◽

Cancer Risk ◽

Gene Polymorphism ◽

Cancer Patients ◽

Mutant Allele ◽

Susceptibility Gene ◽

Chi Square ◽

Endometrial Cancer Risk ◽

Clinical Index ◽

Increased Risk

Abstract Background Endometrial cancer is one of the most common female reproductive system tumors. Ninjurin2 (NINJ2) is a new adhesion factor. As a vascular susceptibility gene, it is highly expressed in other cancers and promotes the growth of cancer cells. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk. Methods Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis. Results The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR 1.46, 95% CI 1.04–2.06, p = 0.028; OR 8.43, 95% CI 1.05–67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls. Conclusion The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.

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Ninjurin 2 rs118050317 gene polymorphism and endometrial cancer risk

10.21203/rs.3.rs-35102/v1 ◽

2020 ◽

Author(s):

Yimin Cheng ◽

Liting Yang ◽

Guangyao Shi ◽

Peng Chen ◽

Liang Li ◽

...

Keyword(s):

Endometrial Cancer ◽

Cancer Risk ◽

Gene Polymorphism ◽

Cancer Patients ◽

Mutant Allele ◽

Susceptibility Gene ◽

Chi Square ◽

Endometrial Cancer Risk ◽

Clinical Index ◽

Increased Risk

Abstract Background: Endometrial cancer is one of the most common female reproductive system tumors. As a vascular susceptibility gene, Ninjurin2 (NINJ2) may involve in endometrial carcinogenesis. We conducted an association analysis between NINJ2 gene polymorphism and endometrial cancer risk.Methods: Five SNPs rs118050317, rs75750647, rs7307242, rs10849390 and rs11610368 of NINJ2 gene were genotyped in 351 endometrial cancer patients and 344 healthy controls. The clinical index difference between cases and controls were tested by one-way analysis of variance. The allele and genotype frequency of cases and controls were been compared by Chi-square test. The odds ratios (OR) with 95% confidence interval (95% CI) were examined by logistic regression analysis.Results: The SNP rs118050317 mutant allele C and homozygote CC genotype were significant increased the endometrial cancer risk (OR = 1.46, 95% CI = 1.04 – 2.06, p = 0.028; OR = 8.43, 95% CI = 1.05 – 67.89, p = 0.045). In the clinical index analysis, there were significant higher quantities of CEA, CA125 and AFP in cases serum than controls.Conclusion: The NINJ2 gene polymorphism loci rs118050317 mutant allele C was associated with an increased risk of endometrial cancer. CEA, CA125 and AFP quantities were significant higher in endometrial cancer patients.

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