Endometrial cancer risk after fertility treatment: a population-based cohort study

Women with histologically proven endometriosis/adenomyosis have an increased risk of ovarian cancer. Small studies show conflicting results on the endometrial cancer risk in women with endometriosis/adenomyosis. Therefore, we assessed the incidence of endometrial cancer in women with histologically proven endometriosis or adenomyosis. We performed a population-based retrospective cohort study of 129,862 women with histologically proven endometriosis/adenomyosis, matched with 132,700 women with a nevus selected from the Dutch pathology registry between 1990 and 2015. Histology results for endometrial cancer were retrieved. Crude and age-adjusted odds ratios for endometrial cancer were estimated. In the endometriosis/adenomyosis group, 1827 (1.4%) women had a histological report on endometrial cancer, and in the nevus group, 771 (0.6%) women. The age-adjusted OR for endometrial cancer was 2.58 (95%CI 2.37–2.81). After excluding the first year of follow-up, the age-adjusted OR was 0.76 (95%CI 0.63–0.92), indicating that endometrial cancer is most often found at time of histological diagnosis of endometriosis/adenomyosis. In around 20% of the endometrial cancer cases, the endometrial cancer was not recognized until after hysterectomy. Of these women, 35% had no prior (micro)curettage or biopsy. This study shows an increased incidence of endometrial cancer in women with histologically proven endometriosis and adenomyosis.

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Abstract 1268: High coffee consumption and different brewing methods in relation to postmenopausal endometrial cancer risk in the norwegian women and cancer study: A population-based prospective study

10.1158/1538-7445.am2014-1268 ◽

2014 ◽

Author(s):

Oxana Gavrilyuk ◽

Tonje Braaten ◽

Guri Skeie ◽

Elisabete Weiderpass ◽

Vanessa Dumeaux ◽

...

Keyword(s):

Endometrial Cancer ◽

Cancer Risk ◽

Prospective Study ◽

Coffee Consumption ◽

Population Based ◽

Endometrial Cancer Risk ◽

Cancer Study

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BRCA1 and BRCA2 pathogenic variant carriers and endometrial cancer risk: A cohort study

European Journal of Cancer ◽

10.1016/j.ejca.2020.05.030 ◽

2020 ◽

Vol 136 ◽

pp. 169-175

Author(s):

Sarah J. Kitson ◽

Cemsel Bafligil ◽

Neil A.J. Ryan ◽

Fiona Lalloo ◽

Emma R. Woodward ◽

...

Keyword(s):

Endometrial Cancer ◽

Cohort Study ◽

Cancer Risk ◽

Pathogenic Variant ◽

Brca1 And Brca2 ◽

Endometrial Cancer Risk

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A population based cohort study of patients with multiple colon and endometrial cancer: Correlation of microsatellite instability (msi) status, age at diagnosis and cancer risk

International Journal of Cancer ◽

10.1002/1097-0215(200002)9999:9999<::aid-ijc1093>3.0.co;2-p ◽

2001 ◽

Vol 91 (4) ◽

pp. 486-491 ◽

Cited By ~ 14

Author(s):

Kristina Cederquist ◽

Irina Golovleva ◽

Monica Emanuelsson ◽

Roger Stenling ◽

Henrik Gr�nberg

Keyword(s):

Endometrial Cancer ◽

Cohort Study ◽

Cancer Risk ◽

Microsatellite Instability ◽

Population Based ◽

Age At Diagnosis

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Glycaemic index, glycaemic load and risk of endometrial cancer: a prospective cohort study

Public Health Nutrition ◽

10.1079/phn2005741 ◽

2005 ◽

Vol 8 (7) ◽

pp. 912-919 ◽

Cited By ~ 35

Author(s):

Stephanie AN Silvera ◽

Thomas E Rohan ◽

Meera Jain ◽

Paul D Terry ◽

Geoffrey R Howe ◽

...

Keyword(s):

Endometrial Cancer ◽

Cohort Study ◽

Cancer Risk ◽

Hormone Replacement ◽

Premenopausal Women ◽

Glycaemic Index ◽

Obese Women ◽

Endometrial Cancer Risk ◽

Glycaemic Load

AbstractObjectiveHigh-glycaemic-load diets may increase endometrial cancer risk by increasing circulating insulin levels and, as a consequence, circulating oestrogen levels. Given the paucity of epidemiological data regarding the relationship between dietary glycaemic index and glycaemic load and endometrial cancer risk, we sought to examine these associations using data from a prospective cohort study.Design, setting and subjectsWe examined the association between dietary glycaemic load and endometrial cancer risk in a cohort of 49 613 Canadian women aged between 40 and 59 years at baseline who completed self-administered food-frequency questionnaires between 1982 and 1985. Linkages to national mortality and cancer databases yielded data on deaths and cancer incidence, with follow-up ending between 1998 and 2000.ResultsDuring a mean of 16.4 years of follow-up, we observed 426 incident cases of endometrial cancer. Hazard ratios for the highest versus the lowest quartile level of overall glycaemic index and glycaemic load were 1.47 (95% confidence interval (CI) = 0.90–2.41; P for trend = 0.14) and 1.36 (95% CI = 1.01–1.84; P for trend = 0.21), respectively. No association was observed between total carbohydrate or total sugar consumption and endometrial cancer risk. Among obese women (body mass index > 30 kg m−2) the hazard ratio for the highest versus the lowest quartile level of glycaemic load was 1.88 (95% CI = 1.08–3.29; P for trend = 0.54) and there was a 55% increased risk for the highest versus the lowest quartile level of glycaemic load among premenopausal women. There was also evidence to support a positive association between glycaemic load and endometrial cancer risk among postmenopausal women who had used hormone replacement therapy.ConclusionsOur data suggest that diets with high glycaemic index or high glycaemic load may be associated with endometrial cancer risk overall, and particularly among obese women, premenopausal women and postmenopausal women who use hormone replacement therapy.

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