The Effects of Thymoquinone (Kalonji) on Abdominal Adhesion in Experimental Abdominal Adhesive Model

2019 ◽  
Vol 82 (3) ◽  
pp. 305-309
Author(s):  
Hüseyin Özden ◽  
Oral Saygun ◽  
Çağatay E. Daphan ◽  
Kuzey Aydınuraz ◽  
Oktay Aydın ◽  
...  
Keyword(s):  
Abdominal Adhesion ◽  
Adhesive Model

scholarly journals CFD-DEM Simulation of Spouted Bed Dynamics under High Temperature with an Adhesive Model

Energies ◽  
2021 ◽  
Vol 14 (8) ◽  
pp. 2276
Author(s):  
Zhao Chen ◽  
Lin Jiang ◽  
Mofan Qiu ◽  
Meng Chen ◽  
Rongzheng Liu ◽  
...  
Keyword(s):  
High Temperature ◽  
Particle Surface ◽  
Particle Collision ◽  
Gas Velocity ◽  
Spouted Bed ◽  
Dem Simulation ◽  
Linear Spring ◽  
Adhesion Model ◽  
Adhesive Model ◽  
Damping Model

Particle adhesion is of great importance to coating processes due to its effect on fluidization. Currently, Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) has become a powerful tool for the study of multiphase flows. Various contact force models have also been proposed. However, particle dynamics in high temperature will be changed with particle surface properties changing. In view of this, an adhesion model is developed based on approaching-loading-unloading-detaching idea and particle surface change under high temperature in this paper. Analyses of the adhesion model are given through two particle collision process and validated by experiment. Effects of inlet gas velocity and adhesion intensity on spouted bed dynamics are investigated. It is concluded that fluidization cycle will be accelerated by adhesion, and intensity of fluidization will be marginally enhanced by slight adhesion. Within a certain range, increasing inlet gas velocity will lead to strong intensity of particle motion. A parameter sensitivity comparison of linear spring-damping model and Hertz-Mindlin Model is given, which shows in case of small overlaps, forces calculated by both models have little distinction, diametrically opposed to that of large overlaps.

Honokiol Decreases Intra-Abdominal Adhesion Formation in a Rat Model

2015 ◽  
Vol 79 (3) ◽  
pp. 160-167 ◽  
Author(s):  
Elif Agacayak ◽  
Senem Yaman Tunc ◽  
Mehmet Sait Icen ◽  
Ulas Alabalik ◽  
Fatih Mehmet Findik ◽  
...  
Keyword(s):  
Rat Model ◽  
Adhesion Formation ◽  
Abdominal Adhesion

Abdominal adhesion and laparoscopy in liver diseases

1981 ◽  
Vol 11 (6) ◽  
pp. 397-407 ◽  
Author(s):  
Vittorio Terruzzi ◽  
Gian Luigi Introzzi ◽  
Giorgio Minoli ◽  
Gianni Imperiali ◽  
Giorgio Tadeo ◽  
...  
Keyword(s):  
Liver Diseases ◽  
Abdominal Adhesion

scholarly journals Elasto-plastic-adhesive DEM model for simulating hillslope debris flows: cross comparison with field experiments

2018 ◽  
Author(s):  
Adel Albaba ◽  
Massimiliano Schwarz ◽  
Corinna Wendeler ◽  
Bernard Loup ◽  
Luuk Dorren
Keyword(s):  
Numerical Model ◽  
Flow Velocity ◽  
Debris Flows ◽  
Field Experiments ◽  
Initial Conditions ◽  
Experimental Tests ◽  
Height Velocity ◽  
Model Parameters ◽  
Fine Content ◽  
Adhesive Model

Abstract. This paper presents a Discrete Element-based elasto-plastic-adhesive model which is adapted and tested for producing hillslope debris flows. The numerical model produces three phases of particle contacts: elastic, plastic and adhesion. The model capabilities of simulating different types of cohesive granular flows were tested with different ranges of flow velocities and heights. The basic model parameters, being the basal friction (ϕb) and normal restitution coefficient (ϵn), were calibrated using field experiments of hillslope debris flows impacting two sensors. Simulations of 50 m3 of material were carried out on a channelized surface that is 41 m long and 8 m wide. The calibration process was based on measurements of flow height, flow velocity and the pressure applied to a sensor. Results of the numerical model matched well those of the field data in terms of pressure and flow velocity while less agreement was observed for flow height. Those discrepancies in results were due in part to the deposition of material in the field test which are not reproducible in the model. A parametric study was conducted to further investigate that effect of model parameters and inclination angle on flow height, velocity and pressure. Results of best-fit model parameters against selected experimental tests suggested that a link might exist between the model parameters ϕb and ϵn and the initial conditions of the tested granular material (bulk density and water and fine contents). The good performance of the model against the full-scale field experiments encourages further investigation by conducting lab-scale experiments with detailed variation of water and fine content to better understand their link to the model's parameters.

scholarly journals TMIGD1 Inhibited Abdominal Adhesion Formation by Alleviating Oxidative Stress in the Mitochondria of Peritoneal Mesothelial Cells

2021 ◽  
Vol 2021 ◽  
pp. 1-16
Author(s):  
Yunhua Wu ◽  
Enmeng Li ◽  
Zijun Wang ◽  
Tianli Shen ◽  
Cong Shen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mitochondrial Function ◽  
Adhesion Formation ◽  
Mesothelial Cell ◽  
Mesothelial Cells ◽  
Stress Injury ◽  
Peritoneal Mesothelial Cells ◽  
Abdominal Adhesion ◽  
Adhesion Tissue ◽  
Peritoneal Mesothelial Cell

Background. Postoperative abdominal adhesion remains one of the frequent complications after abdominal surgery and lacks effective intervention. Peritoneal mesothelial cell injury and healing play crucial roles in the process of adhesion formation, and identifying this mechanism might provide new insight into possible new therapeutic strategies for this disease. Transmembrane and immunoglobulin domain-containing 1 (TMIGD1) has been proven to protect renal epithelial cells from injury induced by oxidative stress and has also been identified as a novel adhesion molecule. Here, we investigated the role of TMIGD1 and its possible mechanism in adhesion formation. Materials and Methods. Immunohistochemistry (IHC), qPCR, and immunofluorescence (IHF) were used to detect the expression of TMIGD1. The grade and tenacity score of adhesion were used to evaluate the adhesion formation conditions. A TMIGD1-overexpressing HMrSV5 cell line was established. MTT assay, Western blotting, Annexin V apoptosis analysis, and CK19 staining were used to measure mesothelial cell viability, apoptosis, and completeness. ROS and MDA detection were used to measure mesothelial cell oxidative stress levels. JC-1 staining, IHF, and transmission electron microscopy were performed to assess mitochondrial function. Scratch-wound and adhesion assays were used to evaluate the adhesion ability of mesothelial cells. Results. First, we showed that TMIGD1 was decreased in mouse abdominal adhesion tissue and peritoneal mesothelial cells. Second, TMIGD1 overexpression inhibited adhesion formation. Third, TMIGD1 overexpression protected mesothelial cells from hydrogen peroxide- (H2O2-) induced oxidative stress injury. Fourth, TMIGD1 overexpression alleviated oxidative stress by protecting the mitochondrial function of mesothelial cells. In addition, TMIGD1 overexpression enhanced mesothelial cell adhesion. Conclusion. Our findings suggest that TMIGD1 protects mesothelial cells from oxidative stress injury by protecting their mitochondrial function, which is decreased in regular abdominal adhesion tissue. In addition, TMIGD1 enhances peritoneal mesothelial cell adhesion to promote healing.

scholarly journals P044 ATRAUMATIC AND CONSISTENT HERNIA MESH FIXATION: PERFORMANCE AND SAFETY IN A LAPAROSCOPIC IPOM PORCINE MODEL

2021 ◽  
Vol 108 (Supplement_8) ◽  
Author(s):  
Miguel Lopes ◽  
Elisa Bitton ◽  
Elise Devries ◽  
Maria Pereira
Keyword(s):  
Histological Analysis ◽  
Porcine Model ◽  
Mesh Fixation ◽  
Fixation Strength ◽  
Tissue Ingrowth ◽  
Hernia Mesh ◽  
Local Tissue ◽  
Abdominal Adhesion ◽  
Mesh Shrinkage

Abstract Aim Demonstrate the performance and safety of TISSIUM on-demand activated adhesive for atraumatic hernia mesh fixation in a laparoscopic IPOM porcine model. Material and Methods Full thickness 4 cm in diameter excisional abdominal defects (n = 14) were created in pig (n = 8). The defects were repaired through laparoscopic intraperitoneal mesh placement using commercial composite meshes fixed with TISSIUM adhesive (n = 8) or resorbable tacks (n = 6). The animals were sacrificed after 28 and 90 days. An independent pathologist evaluated abdominal adhesion, mesh shrinkage, local tissue tolerance and tissue ingrowth through histological analysis (H&E and Movat Pentacrome) at sacrifice. Fixation strength of the explanted abdominal walls was also assessed via burst-ball. Results No adverse events were observed at implantation or during the survival period. All the meshes were in place at sacrifice. Mesh shrinkage and abdominal adhesion scores were similar between the two groups. Histological analysis of the mesh demonstrated equivalent quality of tissue ingrowth and excellent local tissue tolerance with minimal/mild foreign body response and mononuclear cells inflammation. The repair strength, evaluated through a burst ball method 90 days after implantation, showed no significant difference between the TISSIUM adhesive and tacks. Usability is currently being evaluated in clinically relevant models. Conclusions In this preclinical study the TISSIUM adhesive demonstrated similar fixation strength and quality of repair when compared to commercial tacks. This technology has the potential to impact hernia procedures standardization and reduce pain often associated with current fixation technologies.

scholarly journals Danhong Injection Alleviates Postoperative Intra-abdominal Adhesion in a Rat Model

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Yunhua Wu ◽  
Guangbing Wei ◽  
Junhui Yu ◽  
Zilu Chen ◽  
Zhengshui Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Rat Model ◽  
Transforming Growth Factor ◽  
High Dose ◽  
Collagen Deposition ◽  
Abdominal Adhesions ◽  
Abdominal Adhesion ◽  
Danhong Injection ◽  
Intestinal Adhesion ◽  
And Oxidative Stress

Background. Among all the common complications that occur after abdominal surgery, intestinal adhesion is perhaps the most unpleasant one. However, current methods to treat and prevent intestinal adhesion are limited; thus, exploring new methods to prevent and treat intestinal adhesion is greatly needed. In this study, we demonstrated that Danhong injection (DHI) may be used as a promising method to prevent and treat intra-abdominal adhesion in a rat model. Materials and Methods. Forty-eight rats were randomly divided into six groups. Except for the sham-operated group, all rats underwent cecal abrasion to establish an adhesion model. After the operation, the rats in the DHI-treated groups received different doses of DHI via the tail vein daily, while the other group was treated with the same volume of saline solution. Seven days after the operation, all rats were sacrificed, and the degree of adhesion was evaluated by Nair’s scoring system. The extent of inflammation in the adhesion tissue was detected by HE staining and the expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β (TGF-β). The collagen deposition was assessed by Sirius red staining and α-SMA, MMP9, t-PA, and PAI-1 levels. Oxidative stress was indicated by the level of reactive oxygen species (ROS) in adhesion tissues and by immunohistochemical labeling of Nrf2. Furthermore, rat primary peritoneal mesothelial cells (RPMCs) were treated with H2O2 and DHI, and NF-κB phosphorylation was detected to illustrate the effect of DHI on oxidative stress. Results. The intra-abdominal adhesion scores were significantly decreased in the groups treated with a high dose of DHI compared with the control groups, and the degree of inflammation, fibrosis, and oxidative stress was also significantly decreased. DHI treatment significantly reduced the levels of TNF-α, TGF-β1, and PAI and increased the expression levels of MMP9, Nrf2, and t-PA in the adhesion tissues. ROS levels and NF-κB phosphorylation were significantly reduced in DHI-treated RPMCs compared with the control RPMCs. Conclusion. DHI alleviates the formation of postoperative intra-abdominal adhesions by inhibiting inflammation, collagen deposition, and oxidative stress in a rat model and may serve as a promising drug to prevent intra-abdominal adhesions.

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