The apatinib inhibits breast cancer cell line MDA-MB-231 in vitro by inducing apoptosis, cell cycle arrest, and regulating nuclear factor-κB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling pathways

Nonthermal plasma is a promising novel therapy for the alteration of biological and clinical functions of cells and tissues, including apoptosis and inhibition of tumor progression. This therapy generates reactive oxygen and nitrogen species (RONS), which play a major role in anticancer effects. Previous research has verified that plasma jets can selectively induce apoptosis in various cancer cells, suggesting that it could be a potentially effective novel therapy in combination with or as an alternative to conventional therapeutic methods. In this study, we determined the effects of nonthermal air soft plasma jets on a U87 MG brain cancer cell line, including the dose- and time-dependent effects and the physicochemical and biological correlation between the RONS cascade and p38/mitogen-activated protein kinase (MAPK) signaling pathway, which contribute to apoptosis. The results indicated that soft plasma jets efficiently inhibit cell proliferation and induce apoptosis in U87 MG cells but have minimal effects on astrocytes. These findings revealed that soft plasma jets produce a potent cytotoxic effect via the initiation of cell cycle arrest and apoptosis. The production of reactive oxygen species (ROS) in cells was tested, and an intracellular ROS scavenger, N-acetyl cysteine (NAC), was examined. Our results suggested that soft plasma jets could potentially be used as an effective approach for anticancer therapy.

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Role of nuclear factor κB and mitogen-activated protein kinase signaling in exercise-induced antioxidant enzyme adaptation

Applied Physiology Nutrition and Metabolism ◽

10.1139/h07-098 ◽

2007 ◽

Vol 32 (5) ◽

pp. 930-935 ◽

Cited By ~ 53

Author(s):

Li Li Ji ◽

Maria-Carmen Gomez-Cabrera ◽

Jose Vina

Keyword(s):

Protein Kinase ◽

Nuclear Factor Κb ◽

Mapk Signaling ◽

Mitogen Activated Protein Kinase ◽

Ros Generation ◽

Nuclear Factor ◽

Adaptive Responses ◽

Wide Range ◽

Mitogen Activated Protein ◽

Exercise Induced

Activation of nuclear factor (NF) κB and mitogen-activated protein kinase (MAPK) pathways in skeletal muscle has been shown to enhance the gene expression of several enzymes that play an important role in maintaining oxidant–antioxidant homeostasis, such as mitochondrial superoxide dismutase (MnSOD) and inducible nitric oxide synthase (iNOS). While an acute bout of exercise activates NFκB and MAPK signaling and upregulates MnSOD and iNOS, administration of chemical agents that suppress reactive oxygen species (ROS) production can cause attenuation of exercise-induced MnSOD and iNOS expression. Thus, ROS generation during exercise may have duel effects: the infliction of oxidative stress and damage, and the stimulation of adaptive responses favoring long-term protection. This scenario explains why animals and humans involved in exercise training have demonstrated increased resistance to oxidative damage under a wide range of physiological and pathological stresses.

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Leonurine Exerts Anti-Catabolic and Anti-Apoptotic Effects via Nuclear Factor kappa B (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways in Chondrocytes

Medical Science Monitor ◽

10.12659/msm.916039 ◽

2019 ◽

Vol 25 ◽

pp. 6271-6280 ◽

Cited By ~ 2

Author(s):

Peng-Fei Hu ◽

Fang-Fang Sun ◽

Jing Qian

Keyword(s):

Protein Kinase ◽

Signaling Pathways ◽

Nuclear Factor Kappa B ◽

Mapk Signaling ◽

Mitogen Activated Protein Kinase ◽

Nuclear Factor ◽

Nuclear Factor Kappa ◽

Mitogen Activated Protein ◽

Apoptotic Effects ◽

Mapk Signaling Pathways

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CypA: a Potential Target of Tumor Radiotherapy and/or Chemotherapy

Current Medicinal Chemistry ◽

10.2174/0929867327666201029161055 ◽

2020 ◽

Vol 27 ◽

Author(s):

Man-Yu Chu ◽

He-Cheng Huang ◽

En-Ming Li ◽

Li-Yan Xu

Keyword(s):

Cancer Chemotherapy ◽

Mapk Signaling ◽

Mitogen Activated Protein Kinase ◽

Cycle Arrest ◽

Mitogen Activated Protein ◽

Intracellular Target ◽

Related Proteins ◽

The Impact ◽

Mapk Signaling Pathways

: Cyclophilin A (CypA) is a ubiquitous and highly conserved protein. CypA, the intracellular target protein for the immunosuppressant cyclosporine A (CsA), plays important cellular roles through peptidyl-prolyl cis-trans isomerase (PPIase). Increasing evidence shows that CypA is up-regulated in a variety of human cancers. In addition to being involved in the occurrence and development of multiple tumors, overexpression of CypA also has been shown to be strongly associated with malignant transformation. Surgery, chemotherapy and radiotherapy are the three main treatments for cancer. Chemotherapy and radiotherapy are often used as direct or adjuvant treatments for cancer. However, various side effects and resistance to both chemotherapy and radiotherapy bring great challenges to these two forms of treatment. According recent reports, CypA can improve the chemosensitivity and/or radiosensitivity of cancers, possibly by affecting the expression of drug-resistant related proteins, cell cycle arrest and activation of the mitogen-activated protein kinase (MAPK) signaling pathways. In this review, we focus on the role of CypA in cancer, the impact on cancer chemotherapeutic and radiotherapy sensitivity, and the mechanism of action. It is suggested that CypA may be a novel potential therapeutic target for cancer chemotherapy and/or radiotherapy.

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