Relation of Serum and Salivary Total Sialic Acid and Total Sialic Acid/Total Protein Ratio with Clinical Parameters of Disease Progression in Preeclampsia

2021 ◽  
Author(s):  
Jyothi M. P. D’souza ◽  
Vinitha Ramanath Pai ◽  
Sindhu Harish ◽  
Chitra Shriyan
Keyword(s):  
Sialic Acid ◽  
Disease Progression ◽  
Total Protein ◽  
Clinical Parameters ◽  
Protein Ratio ◽  
Total Sialic Acid

Salivary Total Sialic Acid Levels Increase in Breast Cancer Patients: A Preliminary Study

2011 ◽  
Vol 7 (5) ◽  
pp. 443-447 ◽  
Author(s):  
Leyla Koc Ozturk ◽  
Ebru Emekli-Alturfan ◽  
Emel Kasikci ◽  
Gokhan Demir ◽  
Aysen Yarat
Keyword(s):  
Breast Cancer ◽  
Sialic Acid ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Total Sialic Acid ◽  
Preliminary Study

Studies on the к-casein complex: II. The isolation of a sialic acid-containing fraction by disrupting the complex at low pH in the presence of sodium chloride

1965 ◽  
Vol 32 (1) ◽  
pp. 57-63 ◽  
Author(s):  
R. Beeby
Keyword(s):  
Sialic Acid ◽  
Sodium Chloride ◽  
Deae Cellulose ◽  
Low Ph ◽  
The Other ◽  
Trichloracetic Acid ◽  
Complex Ii ◽  
Total Sialic Acid

SummaryWhen crude к-casein was precipitated at pH 3 in the presence of 0·4m-NaCl the supernatant contained up to 80% of the total sialic acid but no detectable cystine or cysteine. Two fractions were obtained from this supernatant by chromatography on DEAE cellulose; one containing 4–6% sialic acid and the other only onetenth of this amount.Most of the sialic acid of the sialic acid-rich fraction was soluble in 12% trichloracetic acid following treatment with rennin. It is suggested that the glycopeptide released by the action of the enzyme on casein originates from this fraction.

The evaluation of serum total sialic acid and lipid-bound sialic acid levels in chronically exposed rats to 7,12-dimethylbenz(a)anthracene and fluoride

2017 ◽  
Author(s):  
Gokhan Oto ◽  
Suat Ekin ◽  
Hasan Uyar ◽  
Hulya Ozdemir ◽  
Damla Yıldız ◽  
...  
Keyword(s):  
Sialic Acid ◽  
Total Sialic Acid

scholarly journals Relaxin regulates vascular wall remodeling and passive mechanical properties in mice

2011 ◽  
Vol 111 (1) ◽  
pp. 260-271 ◽  
Author(s):  
Dan O. Debrah ◽  
Julianna E. Debrah ◽  
Jamie L. Haney ◽  
Jonathan T. McGuane ◽  
Michael S. Sacks ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Knockout Mice ◽  
Total Protein ◽  
Vascular Remodeling ◽  
Circumferential Strain ◽  
Area Ratio ◽  
Lumen Area ◽  
Protein Ratio ◽  
Wall Area ◽  
Passive Compliance

Administration of recombinant human relaxin (rhRLX) to conscious rats increases global arterial compliance, and small renal arteries (SRA) isolated from these rats demonstrate increased passive compliance. Here we characterize relaxin-induced vascular remodeling and examine its functional relevance. SRA and external iliac arteries (EIA) were examined in rhRLX-treated (1.0 μg/h for 5 days) and relaxin knockout mice. Arterial geometric remodeling and compositional remodeling were quantified using immunohistochemical and biochemical techniques. Vascular mechanical properties were quantified using an ex vivo preparation wherein pressure-diameter data were obtained at various axial lengths. Compared with vehicle-treated mice, SRA from rhRLX-treated mice showed outward geometric remodeling (increased unstressed wall area and wall-to-lumen area ratio), increased smooth muscle cell (SMC) density, reduction in collagen-to-total protein ratio, and unchanged elastin-to-tissue dry weight ratio. Compared with wild-type mice, relaxin knockout mice exhibited the opposite pattern: decreased unstressed wall area and wall-to-lumen area ratio, decreased SMC density, and increased collagen-to-total protein ratio. Although tissue biaxial strain energy of SRA was not different between rhRLX- and vehicle-treated groups at low-to-physiological circumferential and axial strains, it was lower for the rhRLX-treated group at the highest circumferential strain. In contrast to SRA, relaxin administration was not associated with any vascular remodeling or changes in passive mechanics of EIA. Thus relaxin induces both geometric and compositional remodeling in vessel-specific manner. Relaxin-induced geometric remodeling of SRA is responsible for the increase in passive compliance under low-to-physiological levels of circumferential and axial strains, and compositional remodeling becomes functionally relevant only under high circumferential strain.

Failure of therapy with 2,3-dihydroxybenzoic acid to modify the course of sepsis-induced lung injury

1990 ◽  
Vol 69 (5) ◽  
pp. 1893-1902 ◽  
Author(s):  
M. D. Sharpe ◽  
R. A. Mustard ◽  
R. R. Finley ◽  
F. S. Rutledge ◽  
W. J. Sibbald
Keyword(s):  
Lung Injury ◽  
Total Protein ◽  
Cecal Ligation ◽  
Microvascular Permeability ◽  
Vehicle Group ◽  
Radical Scavenger ◽  
Dihydroxybenzoic Acid ◽  
Protein Ratio ◽  
Protein Clearance ◽  
Pulmonary Arterial

Oxidant-induced injury of the pulmonary microvasculature reportedly contributes to an increase in microvascular permeability and pulmonary hypertension, both of which are principal features of acute lung injury (ALI). We tested the hypothesis that antioxidant therapy with 2,3-dihydroxybenzoic acid (DHB), initiated in awake sheep after the development of sepsis-induced ALI, would ameliorate the progression of these lesions. DHB has many actions that suggested to us the potential for demonstrating benefit in ALI complicating sepsis; it is a nontoxic hydroxyl-radical scavenger that also inhibits the cyclooxygenase pathway and acts as a weak iron chelator. In preliminary experiments, we demonstrated that pretreatment with DHB prevented an increase in mean pulmonary arterial pressure, plasma thromboxane A2, measured as its metabolite thromboxane B2, and lymph total protein clearance that otherwise followed an infusion of zymosan-activated plasma (ZAP) in sheep. In subsequent experiments, 12 additional sheep were rendered septic by cecal ligation and perforation. Twenty-four to 36 h after cecal ligation and perforation, an increase in lung microvascular permeability was confirmed, because pulmonary lymph flow had increased by 82% while the mean lymph-to-plasma total protein ratio was unchanged from baseline. At this point, six sheep were then treated with parenteral DHB and six with DHB vehicle for the subsequent 24 h. In contrast to the demonstrated benefit of DHB pretreatment in preventing ALI secondary to an infusion of ZAP, the progressive increase in lymph total protein clearance that complicated septic lung injury in the DHB vehicle group throughout this 24-h study period was not ameliorated in the DHB treatment group. However, DHB did prevent a modest increase in mean pulmonary arterial pressures that was demonstrated in the DHB vehicle group throughout this 24-h treatment period. Although pretreatment prevented ALI after a ZAP infusion, we conclude that DHB only incompletely modified disease progression when administered after the onset of sepsis-induced ALI because it ameliorated the pulmonary hypertensive response without concurrently modifying an increase in lung microvascular fluid flux.

scholarly journals Serum Total Sialic Acid and Highly Sensitive C-reactive Protein: Prognostic Markers for the Diabetic Nephropathy

2016 ◽  
Vol 8 (01) ◽  
pp. 025-029 ◽  
Author(s):  
Vandana Varma ◽  
Meena Varma ◽  
Amit Varma ◽  
Ravindra Kumar ◽  
Anuradha Bharosay ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
Sialic Acid ◽  
Multinomial Logistic Regression ◽  
C Reactive Protein ◽  
Diabetes Mellitus Group ◽  
Reactive Protein ◽  
Total Sialic Acid ◽  
Highly Sensitive ◽  
Hs Crp

ABSTRACT Background: This study was undertaken to evaluate and establish the role of total sialic acid (TSA) and highly sensitive C-reactive protein (hs-CRP) in type 2 diabetes mellitus (T2DM) and its correlation with complications such as diabetic nephropathy. Materials and Methods: One hundred fifty-seven patients with T2DM with nephropathy (DN) and 162 patients of T2DM without nephropathy (DM) along with 165 unrelated age and sex-matched healthy controls were included in the study. Serum glucose (fasting and postprandial) levels, renal profile, and lipid profile were done as per standard protocol. Serum TSA test levels and hs-CRP level were evaluated using thiobarbituric acid assay and immunoturbidimetric method respectively. Results: We observed a higher concentration of serum TSA (82.67 ± 6.63 mg/dl) and hs-CRP (3.2 ± 1.44 mg/L) in diabetic nephropathy than the diabetes mellitus group (73.83 ± 6.90 mg/dl and 2.07 ± 1.32 mg/L, respectively). Both TSA and hs-CRP levels were found significantly correlated with fasting and postprandial blood sugar, hemoglobin A1c, and urine microalbumin levels in both DM and DN groups. Multinomial logistic regression analysis showed that both TSA and hs-CRP was independently associated with diabetic nephropathy. Conclusion: High serum TSA and hs-CRP levels may increase the microangiopathic (diabetic nephropathy) complications of T2DM.

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