scholarly journals Effects of Chronic Voluntary Alcohol Drinking on Thiamine Concentrations, Endoplasmic Reticulum Stress, and Oxidative Stress in the Brain of Crossed High Alcohol Preferring Mice

2019 ◽  
Vol 36 (4) ◽  
pp. 777-787 ◽  
Author(s):  
Hong Xu ◽  
Dexiang Liu ◽  
Jing Chen ◽  
Hui Li ◽  
Mei Xu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Alcohol Drinking ◽  
High Alcohol ◽  
The Brain ◽  
And Oxidative Stress

scholarly journals Endoplasmic reticulum stress and oxidative stress drive endothelial dysfunction induced by high selenium

2020 ◽  
Author(s):  
Matshediso Zachariah ◽  
Hatem Maamoun ◽  
Larissa Milano ◽  
Margaret P. Rayman ◽  
Lisiane B. Meira ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endothelial Dysfunction ◽  
Endoplasmic Reticulum Stress ◽  
High Selenium ◽  
And Oxidative Stress

Bilirubin and Epigenetic Modifications in Metabolic and Immunometabolic Disorders

2021 ◽  
Vol 21 ◽  
Author(s):  
Mostafa Moradi Sarabi ◽  
Esmaeel Babaeenezhad ◽  
Maral Amini ◽  
Mozhgan Kaviani ◽  
Fakhraddin Naghibalhossaini
Keyword(s):  
Oxidative Stress ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Mitochondrial Dysfunction ◽  
Current Knowledge ◽  
Waste Product ◽  
Epigenetic Modifications ◽  
Mechanisms Of Toxicity ◽  
High Concentrations ◽  
The Brain

: Bilirubin is the main waste product of heme catabolism. At high concentrations, bilirubin may cause toxicity, especially in the brain, kidney, and erythrocytes. Membrane and mitochondrial dysfunction, oxidative stress, apoptosis, necrosis, endoplasmic reticulum stress, excitotoxicity, inflammation, and epigenetic modifications are the main mechanisms of toxicity triggered by bilirubin in susceptible organs. Many studies have shown that there is an interaction between bilirubin and epigenetic modifications in metabolic and immune diseases. In this review, we first outline the toxicity mediated by bilirubin and then summarize the current knowledge linking bilirubin and epigenetic modifications in metabolic and immunometabolic disorders.

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