Understanding Abnormal c-JNK/p38MAPK Signaling Overactivation Involved in the Progression of Multiple Sclerosis: Possible Therapeutic Targets and Impact on Neurodegenerative Diseases

Acid-sensing ion channels (ASICs) are a family of proton-sensing channels that are voltage insensitive, cation selective (mostly permeable to Na+), and nonspecifically blocked by amiloride. Derived from 5 genes (ACCN1–5), 7 subunits have been identified, 1a, 1b, 2a, 2b, 3, 4, and 5, that are widely expressed in the peripheral and central nervous system as well as other tissues. Over the years, different studies have shown that activation of these channels is linked to various physiological and pathological processes, such as memory, learning, fear, anxiety, ischemia, and multiple sclerosis to name a few, so their potential as therapeutic targets is increasing. This review focuses on recent advances that have helped us to better understand the role played by ASICs in different pathologies related to neurodegenerative diseases, inflammatory processes, and pain.

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Faculty Opinions recommendation of Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1102179.582859 ◽

2008 ◽

Author(s):

Valder Arruda

Keyword(s):

Multiple Sclerosis ◽

Proteomic Analysis ◽

Therapeutic Targets ◽

Active Multiple Sclerosis

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Potential Therapeutic Targets for Neurodegenerative Diseases: Lessons Learned from Calorie Restriction

Current Drug Targets ◽

10.2174/1389450111007011281 ◽

2010 ◽

Vol 11 (10) ◽

pp. 1281-1292 ◽

Cited By ~ 14

Author(s):

Wenzhen Duan ◽

Christopher A. Ross

Keyword(s):

Neurodegenerative Diseases ◽

Calorie Restriction ◽

Therapeutic Targets ◽

Lessons Learned

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Fundamental study on clarification of brain molecular pathology of Nasu-Hakola disease

Impact ◽

10.21820/23987073.2019.8.24 ◽

2019 ◽

Vol 2019 (8) ◽

pp. 24-26

Author(s):

Jun-ichi Satoh

Keyword(s):

Multiple Sclerosis ◽

Human Brain ◽

Clinical Research ◽

Neurodegenerative Diseases ◽

Molecular Pathology ◽

Large Scale ◽

Molecular Pathogenesis ◽

Novel Therapies ◽

Brain Pathology ◽

Fundamental Study

Brain pathology expert Dr Jun-ichi Satoh, from the Department of Bioinformatics and Molecular Neuropathology of Meiji Pharmaceutical University in Tokyo, is drawing on his expertise on neurology and neuroimmunology to delve into some of the more complex diseases impacting the human brain. His knowledge and expertise have allowed him to direct his research interests to study neurodegenerative diseases, such as Alzheimer's disease (AD), and neuroinflammatory diseases, such as multiple sclerosis (MS), and the analysis of their molecular pathogenesis by using a bioinformatics approach. His current focus is on Nasu-Hakola disease (NHD), a disease whose rarity has posed significant barriers towards performing large-scale clinical research in order to understand what exactly causes this disease and develop effective novel therapies.

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The Seaweed Diet in Prevention and Treatment of the Neurodegenerative Diseases

Marine Drugs ◽

10.3390/md19030128 ◽

2021 ◽

Vol 19 (3) ◽

pp. 128

Author(s):

Leonel Pereira ◽

Ana Valado

Keyword(s):

Multiple Sclerosis ◽

Fatty Acids ◽

Neurodegenerative Diseases ◽

Marine Algae ◽

Gelling Agents ◽

Prevention And Treatment ◽

Pharmaceutical Industries ◽

Therapeutic Properties ◽

Main Components ◽

Long Chain

Edible marine algae are rich in bioactive compounds and are, therefore, a source of bioavailable proteins, long chain polysaccharides that behave as low-calorie soluble fibers, metabolically necessary minerals, vitamins, polyunsaturated fatty acids, and antioxidants. Marine algae were used primarily as gelling agents and thickeners (phycocolloids) in food and pharmaceutical industries in the last century, but recent research has revealed their potential as a source of useful compounds for the pharmaceutical, medical, and cosmetic industries. The green, red, and brown algae have been shown to have useful therapeutic properties in the prevention and treatment of neurodegenerative diseases: Parkinson, Alzheimer’s, and Multiple Sclerosis, and other chronic diseases. In this review are listed and described the main components of a suitable diet for patients with these diseases. In addition, compounds derived from macroalgae and their neurophysiological activities are described.

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Paraoxonase Role in Human Neurodegenerative Diseases

Antioxidants ◽

10.3390/antiox10010011 ◽

2020 ◽

Vol 10 (1) ◽

pp. 11

Author(s):

Cadiele Oliana Reichert ◽

Debora Levy ◽

Sergio P. Bydlowski

Keyword(s):

Oxidative Stress ◽

Multiple Sclerosis ◽

Amyotrophic Lateral Sclerosis ◽

Neurodegenerative Diseases ◽

High Density Lipoprotein ◽

Density Lipoprotein ◽

Structural Homology ◽

Redox Systems ◽

Genetic Cluster ◽

Lateral Sclerosis

The human body has biological redox systems capable of preventing or mitigating the damage caused by increased oxidative stress throughout life. One of them are the paraoxonase (PON) enzymes. The PONs genetic cluster is made up of three members (PON1, PON2, PON3) that share a structural homology, located adjacent to chromosome seven. The most studied enzyme is PON1, which is associated with high density lipoprotein (HDL), having paraoxonase, arylesterase and lactonase activities. Due to these characteristics, the enzyme PON1 has been associated with the development of neurodegenerative diseases. Here we update the knowledge about the association of PON enzymes and their polymorphisms and the development of multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD) and Parkinson’s disease (PD).

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