scholarly journals Colorectal cancer in Saudi Arabia as the proof-of-principle model for implementing strategies of predictive, preventive, and personalized medicine in healthcare

2019 ◽  
Vol 11 (1) ◽  
pp. 119-131 ◽  
Author(s):  
Mesnad Alyabsi ◽  
Abdulrahman Alhumaid ◽  
Haafiz Allah-Bakhsh ◽  
Mohammed Alkelya ◽  
Mohammad Azhar Aziz
Keyword(s):  
Colorectal Cancer ◽  
Saudi Arabia ◽  
Personalized Medicine ◽  
Preventive And Personalized Medicine ◽  
Implementing Strategies ◽  
And Personalized Medicine ◽  
Proof Of Principle

scholarly journals Inflammatory and metabolic profiles of patients with end-stage renal disease: potential strategy for predictive, preventive, and personalized medicine

2021 ◽  
Author(s):  
Xiaoxin Ma ◽  
Yongli Wang ◽  
Hongyu Wu ◽  
Fei Li ◽  
Xiping Feng ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
End Stage Renal Disease ◽  
Healthy Controls ◽  
Preventive And Personalized Medicine ◽  
Hydroxyphenylacetic Acid ◽  
Potential Strategy ◽  
Stage Renal Disease ◽  
End Stage ◽  
Esrd Patients ◽  
And Personalized Medicine

Abstract Objectives Few studies reported the periodontal disease-related metabolic profile of end-stage renal disease (ESRD) patients. The present study aimed to compare the inflammatory and metabolic differences between patients with ESRD and healthy controls, and to identify potential useful biomarkers for predictive, preventive, and personalized medicine (PPPM) in GCP and serum of ESRD patients.Methods Patients with ESRD (ESRD group; n = 52) and healthy controls (HC group; n = 44) were recruited. Clinical periodontal parameters were recorded. The differential metabolites in the GCF and serum were identified by liquid chromatography/mass spectrometry. Inflammatory markers including Interleukin-1β (IL-1β), Interleukin-6 (IL-6), Interleukin-8 (IL-8) and C-reactive protein (CRP) were also assessed. Results In ESRD group, IL-8 and CRP were significantly higher in GCF, whereas IL-6 and CRP were significantly higher in serum, compared with HC group (all P < 0.05). In the case of GCF, taurine levels were positively correlated with IL-8 levels in both groups (all P < 0.05). In the case of serum, L-phenylalanine and p-hydroxyphenylacetic acid levels were positively correlated with CRP levels in both groups (all P < 0.05). Significant positive correlation was observed between pseudouridine and IL-6 levels only in ESRD group. Conclusions IL-8 and CRP were potential inflammatory makers. Metabolites of taurine in GCF as well as L-phenylalanine and p-hydroxyphenylacetic acid in serum were possible biomarkers that correlated with inflammatory cytokine. All these biomarkers may consider as a potential strategy for the prediction, diagnosis, prognosis, and management of personalized periodontal therapy in the population with ESRD.

scholarly journals Breast Cancer in Young Women: Status Quo and Advanced Disease Management by a Predictive, Preventive, and Personalized Approach

Cancers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1791 ◽  
Author(s):  
Erik Kudela ◽  
Marek Samec ◽  
Peter Kubatka ◽  
Marcela Nachajova ◽  
Zuzana Laucekova ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Personalized Medicine ◽  
Disease Management ◽  
Young Women ◽  
Screening Tools ◽  
Molecular Signature ◽  
Young Females ◽  
Preventive And Personalized Medicine ◽  
Personalized Approach ◽  
And Personalized Medicine

Why does healthcare of breast cancer (BC) patients, especially in a young population, matter and why are innovative strategies by predictive, preventive, and personalized medicine (PPPM) strongly recommended to replace current reactive medical approach in BC management? Permanent increase in annual numbers of new BC cases with particularly quick growth of premenopausal BC patients, an absence of clearly described risk factors for those patients, as well as established screening tools and programs represent important reasons to focus on BC in young women. Moreover, "young" BC cases are frequently "asymptomatic", difficult to diagnose, and to treat effectively on time. The objective of this article is to update the knowledge on BC in young females, its unique molecular signature, newest concepts in diagnostics and therapy, and to highlight the concepts of predictive, preventive, and personalized medicine with a well-acknowledged potential to advance the overall disease management.

scholarly journals Determination of irinotecan, SN-38 and SN-38 glucuronide using HPLC/MS/MS: Application in a clinical pharmacokinetic and personalized medicine in colorectal cancer patients

2017 ◽  
Vol 32 (1) ◽  
pp. e22217 ◽  
Author(s):  
Chalirmporn Atasilp ◽  
Pichai Chansriwong ◽  
Ekapob Sirachainan ◽  
Thanyanan Reungwetwattana ◽  
Apichaya Puangpetch ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Personalized Medicine ◽  
Cancer Patients ◽  
Clinical Pharmacokinetic ◽  
Colorectal Cancer Patients ◽  
And Personalized Medicine

The application of genomic and proteomic technologies in predictive, preventive and personalized medicine

2006 ◽  
Vol 45 (5) ◽  
pp. 258-267 ◽  
Author(s):  
C.D. Collins ◽  
S. Purohit ◽  
R.H. Podolsky ◽  
H.S. Zhao ◽  
D. Schatz ◽  
...  
Keyword(s):  
Personalized Medicine ◽  
Preventive And Personalized Medicine ◽  
And Personalized Medicine
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