scholarly journals Population-based case-control study revealed metabolomic biomarkers of suboptimal health status in Chinese population—potential utility for innovative approach by predictive, preventive, and personalized medicine

2020 ◽  
Vol 11 (2) ◽  
pp. 147-160 ◽  
Author(s):  
Hao Wang ◽  
Qiuyue Tian ◽  
Jie Zhang ◽  
Hongqi Liu ◽  
Xiaoyu Zhang ◽  
...  
2012 ◽  
Vol 12 (1) ◽  
pp. 19-27 ◽  
Author(s):  
Henry WC Leung ◽  
Agnes LF Chan ◽  
Daniel Lo ◽  
John Hang Leung ◽  
Hsiao-Ling Chen

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Tian Wang ◽  
Jieyu Chen ◽  
Xiaomin Sun ◽  
Lei Xiang ◽  
Lin Zhou ◽  
...  

To explore the effects of traditional Chinese medicine constitution (TCMC) on transformation of good health status to suboptimal health status (SHS), we conducted a nested case-control study among college students in China. During the 18-month mean follow-up time, 543 cases of SHS (42.7%) occurred in 1273 healthy students. There was a significant (P=0.000) and marked reduction in SHMS V1.0 total score in the case group at the 18-month follow-up (69.32 ± 5.45) compared with baseline (78.60 ± 4.70), but there was no significant change in the control group. Conditional logistic regression analysis showed that respondents reporting Yin-deficiency and Qi-deficiency were, respectively, 2.247 and 2.198 times more likely to develop SHS, while tendency to Yin-deficiency and tendency to Damp-heat were, respectively, 1.642 and 1.506 times more likely to develop SHS. However, the Balanced Constitution was a significant protective factor (OR 0.649;P<0.05). Altogether, these findings demonstrate that Yin-deficiency, Qi-deficiency, tendency to Yin-deficiency, and tendency to Damp-heat appeared to induce a change in health status to SHS, while the Balanced Constitution seemed to restrain this change. We conclude that regulating the unbalanced TCMC (such as Yin-deficiency and Qi-deficiency) may prevent a healthy status developing into SHS or lead to the regression of SHS.


2013 ◽  
Vol 6 (7) ◽  
pp. 711-718 ◽  
Author(s):  
Zi-Yi Jin ◽  
Ming Wu ◽  
Ren-Qiang Han ◽  
Xiao-Feng Zhang ◽  
Xu-Shan Wang ◽  
...  

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