scholarly journals Effects of TCMC on Transformation of Good Health Status to Suboptimal Health Status: A Nested Case-Control Study

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Tian Wang ◽  
Jieyu Chen ◽  
Xiaomin Sun ◽  
Lei Xiang ◽  
Lin Zhou ◽  
...  
Keyword(s):  
Health Status ◽  
Case Control Study ◽  
Good Health ◽  
Case Control ◽  
Yin Deficiency ◽  
Suboptimal Health Status ◽  
Nested Case Control ◽  
Control Study ◽  
Suboptimal Health

To explore the effects of traditional Chinese medicine constitution (TCMC) on transformation of good health status to suboptimal health status (SHS), we conducted a nested case-control study among college students in China. During the 18-month mean follow-up time, 543 cases of SHS (42.7%) occurred in 1273 healthy students. There was a significant (P=0.000) and marked reduction in SHMS V1.0 total score in the case group at the 18-month follow-up (69.32 ± 5.45) compared with baseline (78.60 ± 4.70), but there was no significant change in the control group. Conditional logistic regression analysis showed that respondents reporting Yin-deficiency and Qi-deficiency were, respectively, 2.247 and 2.198 times more likely to develop SHS, while tendency to Yin-deficiency and tendency to Damp-heat were, respectively, 1.642 and 1.506 times more likely to develop SHS. However, the Balanced Constitution was a significant protective factor (OR 0.649;P<0.05). Altogether, these findings demonstrate that Yin-deficiency, Qi-deficiency, tendency to Yin-deficiency, and tendency to Damp-heat appeared to induce a change in health status to SHS, while the Balanced Constitution seemed to restrain this change. We conclude that regulating the unbalanced TCMC (such as Yin-deficiency and Qi-deficiency) may prevent a healthy status developing into SHS or lead to the regression of SHS.

scholarly journals Association of circulating let-7b-5p with major depressive disorder: a nested case-control study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sanne Roumans ◽  
Kristina Sundquist ◽  
Ashfaque A. Memon ◽  
Anna Hedelius ◽  
Jan Sundquist ◽  
...  
Keyword(s):  
Major Depressive Disorder ◽  
Depressive Disorder ◽  
Case Control Study ◽  
Case Control ◽  
Major Depressive ◽  
Expression Levels ◽  
Nested Case Control ◽  
Underlying Pathophysiology ◽  
Control Study

Abstract Background Major depressive disorder (MDD) is one of the most common psychiatric disorders and is a great disease burden. However, its underlying pathophysiology and aetiology remain poorly understood. Available evidence suggests that circulating microRNAs (miRNAs) are associated with MDD, but it is still unknown whether miRNAs can predict subsequent incident MDD. Methods In this nested case-control study, a total of 104 individuals, who were free of MDD at baseline, from the Women’s Health in Lund Area (WHILA) cohort were included. Among them, 52 individuals developed MDD (cases) during the 5 years follow-up and 52 individuals did not develop MDD (controls). Plasma expression levels of miR-17-5p, miR-134-5p, miR-144-5p, let-7b-5p and let-7c-5p at baseline were assessed using qRT-PCR. Logistic regression was used to estimate the odds of developing MDD among individuals with different levels of miRNA expression. Results Plasma expression levels of let-7b-5p were significantly lower (p = 0.02) at baseline in cases compared to controls. After adjustment for age and BMI, let-7b-5p was negatively associated with odds for developing MDD (OR = 0.33, p = 0.03, 95% CI = 0.12–0.91). Moreover, let-7b-5p expression levels showed a trend over time with larger differences between cases and controls for the earlier cases (MDD diagnosis <2 years from baseline) than MDD cases developed later (MDD diagnosis 2–5 years from baseline). Conclusions These findings show that lower plasma levels of let-7b-5p are associated with a higher future risk of MDD. Results need to be validated in a large cohort to examine its potential as a peripheral biomarker for MDD.

The association between age-related macular degeneration (AMD) and renal cell carcinoma (RCC): A nested case-control study.

2017 ◽  
Vol 35 (6_suppl) ◽  
pp. 443-443
Author(s):  
Daniel Keizman ◽  
Keren Rouvinov ◽  
Avivit Neumann ◽  
Yu-Xiao Yang ◽  
Maya Gottfried ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Macular Degeneration ◽  
Case Control Study ◽  
Case Control ◽  
Age Related Macular Degeneration ◽  
Diagnostic Code ◽  
Age Related ◽  
Nested Case Control ◽  
Control Study

443 Background: Overexpression of vascular endothelial growth factor (VEGF) is implicated in the pathogenesis of both RCC and AMD. To date, there are no data on an association between AMD and RCC. In the present nested case control study, we aimed to evaluated the association between age-related macular degeneration and RCC risk. Methods: We conducted a matched case-control study within a population-representative database from the United Kingdom. Study cases were defined as individuals with any diagnostic code of RCC. For every case, four eligible controls were matched on age, sex, practice site, time, and duration of follow-up. Exposure of interest was diagnosis of AMD prior to cancer diagnosis. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for RCC were estimated using conditional logistic regression. Adjustment was performed for confounders associated with both AMD and RCC such as smoking, obesity, hypertension, and diabetes. Furthermore, in a secondary analysis, we evaluated the association between other non-VEGF associated retinopathies and RCC, and between AMD and pancreatic cancer, a malignancy characterized by hypovascularity in contrast to the hypervascularity of RCC. Results: The study population included 1,547 patients with RCC and 6,066 matched controls. Median follow-up time was 6 years (IQR 3-9). AMD diagnosis was associated with a significantly increased RCC risk (OR 1.89, 95% CI 1.09-3.29). In contrast, there was no association between other retinopathies and RCC risk (OR 0.8, 95% CI 0.56-1.15). AMD was associated with a lower risk for pancreatic cancer (OR 0.47, 95% CI 0.35-0.64). Conclusions: Patients with AMD may be at higher risk for RCC. Providers should consider screening for RCC within this population.

scholarly journals P742 Morbidity and mortality outcomes of paediatric-onset inflammatory bowel disease in early adult life: A Scottish population-based, nested case–control study

2020 ◽  
Vol 14 (Supplement_1) ◽  
pp. S593-S594
Author(s):  
C Burgess ◽  
C Schnier ◽  
I Chalmers ◽  
R K Russell ◽  
R Hansen ◽  
...  
Keyword(s):  
Case Control Study ◽  
Adult Life ◽  
Population Based ◽  
Case Control ◽  
Scottish Population ◽  
Early Adult Life ◽  
Inflammatory Bowel ◽  
Nested Case Control ◽  
Control Study

Abstract Background The risk of morbidity and mortality related to paediatric-onset inflammatory bowel disease (PIBD) and its treatment is a major concern to both patients and clinicians, especially when this may affect early adult life. We aimed to determine whether PIBD patients are at increased risk of ischaemic heart disease (IHD), stroke, cancer and death in a nationwide population-based study using administrative health data research methodology. Methods All children diagnosed with PIBD in Scotland 1981–2017 were identified within the Scottish Morbidity Record inpatient and day-case dataset (SMR01). PIBD cases were defined as any inpatient International Classification of Diseases (ICD) coding for Crohn’s disease (CD; 555/K50) or ulcerative colitis (UC; 556/K51) until age 16; 10% of cases were individually validated. A nested case-control study (1:3 ratio) matched for sex, age, postcode sector and deprivation quintile within the Scottish population was performed. Data-linkage was applied to SMR01, SMR06 (Scottish Cancer Registry) and NRS deaths datasets to identify any diagnosis of IHD, acute stroke, cancer or mortality. Cancer diagnoses were classified into potential disease related (small bowel, colonic, rectal, anal, hepatobiliary) or treatment related (lymphoma, leukaemia, myeloma, PTLD) cancers. Hazard ratios (HR) were calculated for each outcome using mixed effects Cox regression and the potential effect of sex, year of diagnosis and age at diagnosis were explored. Results The study population comprised 2484 children with PIBD and 7451 matched controls. Median age of PIBD diagnosis was 12 years (IQR 10–14) and age at end of follow-up 24 years (IQR 17–33) with 141,605 total person-years follow-up. Validation identified 242/261 true positive cases (positive predictive value 93%). 2 cases (0.08%) and 7 controls (0.09%) had an admission for IHD during follow-up (p = 0.845); 6 cases (0.24%) and 5 controls (0.07%) were admitted for stroke (p = 0.024). PIBD cases had a significantly higher risk of any cancer diagnosis (62 cases: 97 controls) HR 1.97 (p &lt; 0.001), including a 31.9 times higher risk of disease-related cancers (p &lt; 0.001) and a 6 times higher risk of treatment-related cancers (p = 0.011). The effect of PIBD on cancer risk was higher in males, but not related to year or age. PIBD cases had a greater risk of mortality (60 cases: 51 controls) HR 3.61 (p &lt; 0.001). The specific mortality risk from infection was 21.4 times higher in PIBD cases (p = 0.004); the risk of suicide was 2.4 times higher but not statistically significant (p = 0.085). The effect of PIBD on mortality risk was not modified by sex, year or age. Conclusion Cancer and mortality are meaningful, serious early adult life adverse sequelae of PIBD however IHD and stroke occur infrequently.

scholarly journals Exposure to preeclampsia in utero affects growth from birth to late childhood dependent on child’s sex and severity of exposure: Follow-up of a nested case-control study

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176627 ◽  
Author(s):  
Kristine Kjer Byberg ◽  
Knut Øymar ◽  
Geir Egil Eide ◽  
Michele R. Forman ◽  
Pétur Benedikt Júlíusson
Keyword(s):  
Case Control Study ◽  
In Utero ◽  
Case Control ◽  
Late Childhood ◽  
Nested Case Control ◽  
Control Study
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