7SK small nuclear RNA inhibits cancer cell proliferation through apoptosis induction

Tumor Biology ◽  
2014 ◽  
Vol 36 (4) ◽  
pp. 2809-2814 ◽  
Author(s):  
Farid Keramati ◽  
Ehsan Seyedjafari ◽  
Parviz Fallah ◽  
Masoud Soleimani ◽  
Hossein Ghanbarian
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Small Nuclear Rna ◽  
Apoptosis Induction ◽  
Nuclear Rna

Inhibition of Pancreatic Cancer Cell Proliferation by Propranolol Occurs Through Apoptosis Induction

Pancreas ◽  
2009 ◽  
Vol 38 (1) ◽  
pp. 94-100 ◽  
Author(s):  
Dong Zhang ◽  
Qingyong Ma ◽  
Sugang Shen ◽  
Hengtong Hu
Keyword(s):  
Pancreatic Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Apoptosis Induction

Novel Amphiphilic G-Quadruplex Binding Synthetic Derivative of TMPyP4 and Its Effect on Cancer Cell Proliferation and Apoptosis Induction

Biochemistry ◽  
2018 ◽  
Vol 57 (46) ◽  
pp. 6514-6527 ◽  
Author(s):  
Ushasri Chilakamarthi ◽  
Devulapally Koteshwar ◽  
Sudhakar Jinka ◽  
Narra Vamsi Krishna ◽  
Kathyayani Sridharan ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Apoptosis Induction ◽  
G Quadruplex ◽  
Proliferation And Apoptosis ◽  
Synthetic Derivative

NF-κB regulates colon cancer cell proliferation and tumorigenicity

2001 ◽  
Vol 120 (5) ◽  
pp. A615-A615
Author(s):  
S KUWADA ◽  
C SCAIFE ◽  
J KUANG ◽  
R DAYNES
Keyword(s):  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Proliferation

Compounds inhibiting hyperglycemia and cancer cell proliferation from Morus alba L

Planta Medica ◽  
2012 ◽  
Vol 78 (11) ◽  
Author(s):  
S Sun ◽  
M Zhang ◽  
M Li ◽  
F Guan ◽  
F Wu ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Morus Alba ◽  
Cancer Cell Proliferation

Exendin-4, a Glucagon-Like Peptide-1 Receptor Agonist, Attenuates Prostate Cancer Cell Proliferation via Phosphorylation of MKP-1

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1957-P
Author(s):  
TAKAKO KAWANAMI ◽  
TAKASHI NOMIYAMA ◽  
YURIKO HAMAGUCHI ◽  
TOMOKO TANAKA ◽  
TOSHIHIKO YANASE
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cell ◽  
Receptor Agonist ◽  
Prostate Cancer Cell ◽  
Cancer Cell Proliferation ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

ARFGAP3 an androgen target gene promotes prostate cancer cell proliferation and migration.

2020 ◽  
Author(s):  
Lungwani Muungo
Keyword(s):  
Cell Proliferation ◽  
Cancer Cell ◽  
Cell Biology ◽  
Adaptor Protein ◽  
Cancer Cell Proliferation ◽  
Lncap Cells ◽  
Gtpase Activating Protein ◽  
Cell Proliferation And Migration ◽  
And Migration ◽  
Proliferation And Migration

ADP ribosylation factor GTPase-activating protein 3 (ARFGAP3) is a GTPase-activating protein that associates with the Golgiapparatus and regulates the vesicular trafficking pathway. In the present study, we examined the contribution of ARFGAP3 toprostate cancer cell biology. We showed that ARFGAP3 expression was induced by 100 nM of dihydrotestosterone (DHT) atboth the mRNA and protein levels in androgen-sensitive LNCaP cells. We generated stable transfectants of LNCaP cells withFLAG-tagged ARFGAP3 or a control empty vector and showed that ARFGAP3 overexpression promoted cell proliferation andmigration compared with control cells. We found that ARFGAP3 interacted with paxillin, a focal adhesion adaptor protein thatis important for cell mobility and migration. Small interfering RNA (siRNA)-mediated knockdown of ARFGAP3 showed thatARFGAP3 siRNA markedly reduced LNCaP cell growth. Androgen receptor (AR)-dependent transactivation activity on prostatespecificantigen (PSA) enhancer was synergistically promoted by exogenous ARFGAP3 and paxillin expression, as shown byluciferase assay in LNCaP cells. Thus, our results suggest that ARFGAP3 is a novel androgen-regulated gene that can promoteprostate cancer cell proliferation and migration in collaboration with paxillin.

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