Preoperative platelet/lymphocyte ratio is a superior prognostic factor compared to other systemic inflammatory response markers in ovarian cancer patients

Tumor Biology ◽  
2015 ◽  
Vol 36 (11) ◽  
pp. 8831-8837 ◽  
Author(s):  
Wei-wei Zhang ◽  
Ke-jun Liu ◽  
Guo-lin Hu ◽  
Wei-jiang Liang
Keyword(s):  
Ovarian Cancer ◽  
Prognostic Factor ◽  
Inflammatory Response ◽  
Cancer Patients ◽  
Systemic Inflammatory Response ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio

scholarly journals Systemic Inflammatory Response Based on Neutrophil-to-Lymphocyte Ratio as a Prognostic Marker in Bladder Cancer

2016 ◽  
Vol 2016 ◽  
pp. 1-12 ◽  
Author(s):  
Hyung Suk Kim ◽  
Ja Hyeon Ku
Keyword(s):  
Inflammatory Response ◽  
Cancer Patients ◽  
Systemic Inflammatory Response ◽  
Neutrophil To Lymphocyte Ratio ◽  
Oncologic Outcomes ◽  
Survival Outcomes ◽  
Lymphocyte Ratio ◽  
The Past ◽  
Differential White Blood Cell

A growing body of evidence suggests that systemic inflammatory response (SIR) in the tumor microenvironment is closely related to poor oncologic outcomes in cancer patients. Over the past decade, several SIR-related hematological factors have been extensively investigated in an effort to risk-stratify cancer patients to improve treatment selection and to predict posttreatment survival outcomes in various types of cancers. In particular, one readily available marker of SIR is neutrophil-to-lymphocyte ratio (NLR), which can easily be measured on the basis of absolute neutrophils and absolute lymphocytes in a differential white blood cell count performed in the clinical setting. Many investigators have vigorously assessed NLR as a potential prognostic biomarker predicting pathological and survival outcomes in patients with urothelial carcinoma (UC) of the bladder. In this paper, we aim to present the prognostic role of NLR in patients with UC of the bladder through a thorough review of the literature.

scholarly journals Can Preoperative Neutrophil-Lymphocyte Ratio and Platelet-Lymphocyte Ratio Predict Systemic Inflammatory Response Syndrome That Develops After Percutaneous Nephrolithotomy?

2021 ◽  
Author(s):  
Uygar Miçooğulları ◽  
Orçun Çelik ◽  
Mehmet Çağlar Çakıcı ◽  
Erdem Kısa ◽  
Cem Yücel ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Systemic Inflammatory Response Syndrome ◽  
Inflammatory Response ◽  
Percutaneous Nephrolithotomy ◽  
Systemic Inflammatory Response ◽  
Blood Transfusions ◽  
Multivariate Logistic Regression ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Platelet Lymphocyte Ratio

Objective: First objective of this study was to find out factors influencing development of postoperative systemic inflammatory response syndrome (SIRS) after percutaneous nephrolithotomy (PNL). Secondary objective was to point out the role of preoperative neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) in SIRS estimation. Method: The data of 756 patients that underwent PNL for kidney stones between 2012 and 2019 were evaluated retrospectively. Patients were divided into 2 groups as non-SIRS and SIRS group. The effects of NLR, PLR and other operative and demographic variables on development of SIRS were investigated. Multivariate logistic regression analysis that was performed on variables that were significant in the univariate analyses was used to establish independent risk factor for post-PNL SIRS. Results: Univariate analysis revealed a significant association between presence of SIRS and preoperative PLR (p<0.001), preoperative NLR (p<0.001), blood transfusion (p<0.001), stone volume (p=0.03), staghorn stone (p<0.001), and preoperative creatinine levels (<0.001). Multivariate logistic regression analyses of these risk factors showed that NLR (p<0.001), PLR (p<0.001), and blood transfusions (p<0.001) were independently associated with SIRS. When the cut-off value of PLR was 120.5, the development of SIRS was predicted with 80.1% specificity and 81% sensitivity. When the cut-off value of NLR was 2.75, the development of SIRS was predicted with 64% specificity and 63.7% sensitivity. Conclusion: Preoperative PLR and NLR are effective and inexpensive biomarkers that can be used to predict SIRS and sepsis after PNL. We recommend that patients with PLR >120.5, NLR >2.75, and blood transfusions should be monitored closely due to the possible development of serious complications.

The Effects of Water Immersion during First Stage of Labor on Postpartum Systemic Inflammatory Response

2021 ◽  
Author(s):  
Ayçağ Yorgancı ◽  
Gul Nihal Buyuk ◽  
Mesut Akyol ◽  
Özlem Gündüz ◽  
Banu Seven ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Postpartum Period ◽  
Neonatal Intensive Care ◽  
Water Immersion ◽  
Blood Parameters ◽  
Systemic Inflammatory Response ◽  
Lymphocyte Ratio ◽  
Early Postpartum ◽  
Multiparous Women ◽  
First Stage Of Labor

Abstract Objective The systemic inflammatory response is a cascade of physiologic reactions that arise in response to trauma, infection, burn, or any kind of injury. This study aimed to determine the effects of water immersion during the first stage of labor on the systemic inflammatory indices in the postpartum period. Materials and methods In this retrospective study, 125 healthy multiparous women with uncomplicated pregnancies between 37 and 41 weeks of gestation who elected for immersion in water during the first stage of labor were compared with multiparous uncomplicated term women who had conventional vaginal births on land (n=125). Age, parity, body mass index (BMI), gestational age, duration of labor, birth weight, Apgar scores, neonatal intensive care unit admissions, and ante- and postpartum whole blood parameters were noted. Antepartum and postpartum neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) were calculated for all patients as systemic inflammatory indices. Results Demographic characteristics and birth outcomes of both groups were similar except BMI, which was statistically significantly higher in the water immersion group. There were no statistical differences in antepartum NLR, MLR, PLR, and MPV between the 2 groups. However, postpartum NLR, MLR, PLR, and MPV were statistically significantly lower in the water immersion group compared to the controls. Conclusion Water immersion during the first stage of labor might decrease systemic inflammatory indices in the early postpartum period.

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