Histological mixed-type as an independent risk factor for nodal metastasis in submucosal gastric cancer

Tumor Biology ◽  
2015 ◽  
Vol 37 (1) ◽  
pp. 709-714 ◽  
Author(s):  
Mahito Miyamae ◽  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Toshiyuki Kosuga ◽  
Takeshi Kubota ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Mixed Type ◽  
Independent Risk Factor ◽  
Nodal Metastasis ◽  
Submucosal Gastric Cancer

Histological Mixed-Type Early Gastric Cancer Is an Independent Risk Factor for Lymph Node Metastasis: Presidential Poster

2015 ◽  
Vol 110 ◽  
pp. S1031
Author(s):  
Akinori Shimayoshi ◽  
Shunsuke Yamamoto ◽  
Shinjiro Yamaguchi ◽  
Kazuhiro Kozumi ◽  
Eiji Kimura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Mixed Type ◽  
Independent Risk Factor ◽  
Node Metastasis

scholarly journals Clinicopathological significance of primitive phenotypes in early gastric cancer with differentiated histology

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zhi-Yi Zhou ◽  
Jie Sun ◽  
Qing Guo ◽  
Hai-Bin Zhao ◽  
Zhi-Hua Zhou
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Independent Risk Factor ◽  
Lymphatic Invasion ◽  
Clinicopathological Features ◽  
Surgical Operation ◽  
Tissue Sections ◽  
Clinicopathological Significance

Abstract Background Certain gastric cancers exhibit some primitive phenotypes, which may indicate a high malignancy. In histologically differentiated early gastric cancer (EGC), the presence and the clinicopathological significance of the primitive phenotype remain unclear. Methods Using immunohistochemical staining we detected the expression of three primitive phenotypic markers SALL4, Glypican-3(GPC3), and AFP in whole tissue sections of differentiated EGC (gastrectomy specimens, n = 302). For those cases with primitive phenotypes, we analyzed their clinicopathological features and evaluated whether the criteria for endoscopic resection were met. Results We found that 9.3% (28/302) of all differentiated EGC cases have primitive phenotypes, and most of these cases (25/28) exhibit a histomorphology similar to conventional differentiated EGC. Patients with primitive phenotypes had a deeper invasion, a higher rate of ulcer and lymphatic invasion than cases without primitive phenotype. Moreover, patients with primitive phenotypes displayed a significantly higher frequency of LNM than those without (57.1% vs 8.8%, P < 0.001). Multivariate analysis revealed that presence of primitive phenotypes was an independent risk factor for LNM (P = 0.001, HR 6.977, 95% CI: 2.199–22.138). Interestingly, we found 2 cases with primitive phenotypes developed LNM, and they both met the expanded indications of endoscopic resection for differentiated EGC. Conclusions A small number of differentiated EGC have primitive phenotypes, which were closely related to LNM and were an independent risk factor for LNM. Given its highly aggressive behavior, differentiated EGC with primitive phenotypes should be evaluated with stricter criteria before endoscopic resection, or considered to give an additional surgical operation after endoscopic resection.

scholarly journals Expression of stromal cell-derived factor-1α is an independent risk factor for lymph node metastasis in early gastric cancer

2011 ◽  
Vol 2 (6) ◽  
pp. 1197-1202 ◽  
Author(s):  
IK-CHAN SONG ◽  
ZHE-LONG LIANG ◽  
JUNG-CHAN LEE ◽  
SONG-MEI HUANG ◽  
HA-YON KIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Stromal Cell ◽  
Independent Risk Factor ◽  
Node Metastasis ◽  
Stromal Cell Derived Factor

Mo1188 Histologically Mixed-Type Early Gastric Cancer Is a Risk Factor for Metastasis and Recurrence

2017 ◽  
Vol 85 (5) ◽  
pp. AB455-AB456
Author(s):  
Ken Ohnita ◽  
Takuji Gotoda ◽  
Tsuneo Oyama ◽  
Noboru Kawata ◽  
Akiko Takahashi ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Early Gastric Cancer ◽  
Mixed Type

Risk factors for peritoneal recurrence in serosa-negative gastric cancer.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 19-19 ◽  
Author(s):  
Hayato Omori ◽  
Yuichiro Miki ◽  
Wataru Takagi ◽  
Fumiko Hirata ◽  
Taichi Tatsubayashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Multivariate Analysis ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Independent Risk Factor ◽  
Peritoneal Recurrence ◽  
Node Metastasis ◽  
Gastric Cancer Patients

19 Background: Peritoneal recurrence is often observed in gastric cancer patients without serosal invasion. It is difficult for pathologists to evaluate whether tumor cells penetrate serosa or not, because the subserosa layer is very thin. We evaluated the incidence and risk factors of peritoneal recurrence in serosa -negative gastric cancer patients to clarify the mechanism of peritoneal recurrence in these patients. Methods: A total of 1,745 gastric cancer patients underwent R0 resection from 2002 to 2009 were enrolled. The incidence of peritoneal recurrence according to tumor depth was analyzed. In serosa-nagative patients, the univariate and multivariate analysis were performed to identify the risk factors for peritoneal recurrence. Results: Peritoneal recurrence was observed in 64 (3.7 %) out of 1,745 patients. The incidence of peritoneal recurrence according to depth of tumor invasion was in 0 / 466 in T1a, 5 / 567 (0.88 %) in T1b, 4 / 187 (2.1 %) in T2, 31 / 360 (7.9 %) in T3, 20 / 108 (15.9 %) in T4a, and 4 / 12 (25 %) in T4b, respectively (p<0.001). As for the risk factor for peritoneal recurrence in T3 patients, histologically undifferentiated type, negative lymphatic invasion, scirrhous type, invasive infiltrating growth pattern were the significant factors identified by univariate analysis. Only the invasive infiltrating growth pattern (OR3.44 p0.038) was selected as significant independent risk factor for peritoneal recurrence by multivariate analysis. In T1b / T2 patients, massive lymph node metastasis (N3a, 3b), scirrhous type were the significant factor for peritoneal recurrence by univariate analysis. Only massive lymph node metastasis (OR25.1 p<0.001) was selected as the significant independent risk factor by multivariate analysis. Conclusions: The incidence of peritoneal recurrence increases in proportion to the tumor depth. Invasive infiltrating growth pattern was selected as an independent risk factor for peritoneal recurrence in T3 patients, while it was massive lymph node metastasis in T1b / T2 patients. The results suggest the possibility that microscopic serosal invasion in T3 tumor and lymphatic progression in T1b / T2 tumor may contribute to peritoneal recurrence in gastric cancer.

Reconstruction method as an independent risk factor for the postoperative decrease in hemoglobin in stage I gastric cancer

2016 ◽  
Vol 31 (5) ◽  
pp. 959-964 ◽  
Author(s):  
Taisuke Imamura ◽  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Toshiyuki Kosuga ◽  
Kazuma Okamoto ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Stage I ◽  
Reconstruction Method

scholarly journals Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer

2008 ◽  
Author(s):  
Yoshihiko Kitajima ◽  
Kazuma Ohtaka ◽  
Mayumi Mitsuno ◽  
Masayuki Tanaka ◽  
Seiji Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Helicobacter Pylori Infection

scholarly journals Optimal risk classification with statistical evidence in endometrial cancer

2020 ◽  
Author(s):  
Chung Chang ◽  
An Jen Chiang ◽  
Yi Chieh Chiu ◽  
Li-Chuan Hsu ◽  
Pei-Hua Hsu ◽  
...  
Keyword(s):  
Overall Survival ◽  
Endometrial Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Risk Groups ◽  
Nodal Metastasis ◽  
Optimal Number ◽  
Cut Points ◽  
Akaike Criterion ◽  
Statistical Algorithms

Abstract Background It is often clinically useful to classify tumor markers into risk groups. This study was aimed to investigate whether beginning with a statistically sound method would find cut points more reasonable than conventional ones. Methods We used data of endometrial cancer including 442 patients. The optimal number of cutoffs was based on the Akaike criterion and statistical algorithms were adapted to find the best locations. Codes were provided as a package. Results Myometrium invasion was an independent risk factor for lymph nodal metastasis when stratified into three groups by 0.41 and 0.89. Tumor size was an independent risk factor for overall survival when stratified into two groups by 4.11 cm. Both had better prediction than conventional choices and clinical relevance. Conclusion A statistically sound algorithm should be used to stratify patients into risk groups.

scholarly journals Clinical significance of controlling nutritional status score (CONUT) in evaluating outcome of postoperative patients with gastric cancer

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Qi Xiao ◽  
Xiaoqing Li ◽  
Baojun Duan ◽  
Xiaofan Li ◽  
Sida Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Regression Analysis ◽  
Risk Factor ◽  
Postoperative Complications ◽  
Nutritional Status ◽  
Independent Risk Factor ◽  
Multivariate Regression Analysis ◽  
Psychological Status ◽  
The Relationship ◽  
Conut Score

AbstractThe stomach is the main digestive organ in humans. Patients with gastric cancer often develop digestive problems, which result in poor nutrition. Nutritional status is closely related to postoperative complications and quality of life (QoL) in patients with gastric cancer. The controlling nutritional status (CONUT) score is a novel tool to evaluate the nutritional status of patients. However, the relationship of the CONUT score with postoperative complications, QoL, and psychological status in patients with gastric cancer has not been investigated. The present follow-up study was conducted in 106 patients who underwent radical gastrectomy in our hospital between 2014 and 2019. The CONUT score, postoperative complications, psychological status, postoperative QoL scores, and overall survival (OS) of patients with gastric cancer were collected, and the relationship between them was analyzed. A significant correlation was observed between the CONUT score and postoperative complications of gastric cancer (P < 0.001), especially anastomotic leakage (P = 0.037). The multivariate regression analysis exhibited that the CONUT score (P = 0.002) is an independent risk factor for postoperative complications. The CONUT score was correlated with the state anxiety questionnaire (S-AI) for evaluating psychological status (P = 0.032). However, further regression analysis exhibited that the CONUT score was not an independent risk factor for psychological status. Additionally, the CONUT score was associated with postoperative QoL. The multivariate regression analysis exhibited that the CONUT score was an independent risk factor for the global QoL (P = 0.048). Moreover, the efficiency of CONUT score, prognostic nutrition index, and serum albumin in evaluating complications, psychological status, and QoL was compared, and CONUT score was found to outperform the other measures (Area Under Curve, AUC = 0.7368). Furthermore, patients with high CONUT scores exhibited shorter OS than patients with low CONUT scores (P = 0.005). Additionally, the postoperative complications (HR 0.43, 95% CI 0.21–0.92, P = 0.028), pathological stage (HR 2.26, 95% CI 1.26–4.06, P = 0.006), and global QoL (HR 15.24, 95% CI 3.22–72.06, P = 0.001) were associated with OS. The CONUT score can be used to assess the nutritional status of patients undergoing gastric cancer surgery and is associated with the incidence of postoperative complications and QoL.

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