Reconstruction method as an independent risk factor for the postoperative decrease in hemoglobin in stage I gastric cancer

2016 ◽  
Vol 31 (5) ◽  
pp. 959-964 ◽  
Author(s):  
Taisuke Imamura ◽  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Toshiyuki Kosuga ◽  
Kazuma Okamoto ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Stage I ◽  
Reconstruction Method

Reconstruction method as an independent risk factor for postoperative bone mineral density loss in gastric cancer

2018 ◽  
Vol 33 (2) ◽  
pp. 418-425 ◽  
Author(s):  
Taisuke Imamura ◽  
Shuhei Komatsu ◽  
Daisuke Ichikawa ◽  
Toshiyuki Kosuga ◽  
Takeshi Kubota ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Bone Mineral Density ◽  
Risk Factor ◽  
Bone Mineral ◽  
Independent Risk Factor ◽  
Reconstruction Method ◽  
Mineral Density ◽  
Bone Mineral Density Loss

scholarly journals Clinicopathological significance of primitive phenotypes in early gastric cancer with differentiated histology

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Zhi-Yi Zhou ◽  
Jie Sun ◽  
Qing Guo ◽  
Hai-Bin Zhao ◽  
Zhi-Hua Zhou
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Early Gastric Cancer ◽  
Endoscopic Resection ◽  
Independent Risk Factor ◽  
Lymphatic Invasion ◽  
Clinicopathological Features ◽  
Surgical Operation ◽  
Tissue Sections ◽  
Clinicopathological Significance

Abstract Background Certain gastric cancers exhibit some primitive phenotypes, which may indicate a high malignancy. In histologically differentiated early gastric cancer (EGC), the presence and the clinicopathological significance of the primitive phenotype remain unclear. Methods Using immunohistochemical staining we detected the expression of three primitive phenotypic markers SALL4, Glypican-3(GPC3), and AFP in whole tissue sections of differentiated EGC (gastrectomy specimens, n = 302). For those cases with primitive phenotypes, we analyzed their clinicopathological features and evaluated whether the criteria for endoscopic resection were met. Results We found that 9.3% (28/302) of all differentiated EGC cases have primitive phenotypes, and most of these cases (25/28) exhibit a histomorphology similar to conventional differentiated EGC. Patients with primitive phenotypes had a deeper invasion, a higher rate of ulcer and lymphatic invasion than cases without primitive phenotype. Moreover, patients with primitive phenotypes displayed a significantly higher frequency of LNM than those without (57.1% vs 8.8%, P < 0.001). Multivariate analysis revealed that presence of primitive phenotypes was an independent risk factor for LNM (P = 0.001, HR 6.977, 95% CI: 2.199–22.138). Interestingly, we found 2 cases with primitive phenotypes developed LNM, and they both met the expanded indications of endoscopic resection for differentiated EGC. Conclusions A small number of differentiated EGC have primitive phenotypes, which were closely related to LNM and were an independent risk factor for LNM. Given its highly aggressive behavior, differentiated EGC with primitive phenotypes should be evaluated with stricter criteria before endoscopic resection, or considered to give an additional surgical operation after endoscopic resection.

scholarly journals Expression of stromal cell-derived factor-1α is an independent risk factor for lymph node metastasis in early gastric cancer

2011 ◽  
Vol 2 (6) ◽  
pp. 1197-1202 ◽  
Author(s):  
IK-CHAN SONG ◽  
ZHE-LONG LIANG ◽  
JUNG-CHAN LEE ◽  
SONG-MEI HUANG ◽  
HA-YON KIM ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Stromal Cell ◽  
Independent Risk Factor ◽  
Node Metastasis ◽  
Stromal Cell Derived Factor

Risk factors for peritoneal recurrence in serosa-negative gastric cancer.

2015 ◽  
Vol 33 (3_suppl) ◽  
pp. 19-19 ◽  
Author(s):  
Hayato Omori ◽  
Yuichiro Miki ◽  
Wataru Takagi ◽  
Fumiko Hirata ◽  
Taichi Tatsubayashi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Multivariate Analysis ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Independent Risk Factor ◽  
Peritoneal Recurrence ◽  
Node Metastasis ◽  
Gastric Cancer Patients

19 Background: Peritoneal recurrence is often observed in gastric cancer patients without serosal invasion. It is difficult for pathologists to evaluate whether tumor cells penetrate serosa or not, because the subserosa layer is very thin. We evaluated the incidence and risk factors of peritoneal recurrence in serosa -negative gastric cancer patients to clarify the mechanism of peritoneal recurrence in these patients. Methods: A total of 1,745 gastric cancer patients underwent R0 resection from 2002 to 2009 were enrolled. The incidence of peritoneal recurrence according to tumor depth was analyzed. In serosa-nagative patients, the univariate and multivariate analysis were performed to identify the risk factors for peritoneal recurrence. Results: Peritoneal recurrence was observed in 64 (3.7 %) out of 1,745 patients. The incidence of peritoneal recurrence according to depth of tumor invasion was in 0 / 466 in T1a, 5 / 567 (0.88 %) in T1b, 4 / 187 (2.1 %) in T2, 31 / 360 (7.9 %) in T3, 20 / 108 (15.9 %) in T4a, and 4 / 12 (25 %) in T4b, respectively (p<0.001). As for the risk factor for peritoneal recurrence in T3 patients, histologically undifferentiated type, negative lymphatic invasion, scirrhous type, invasive infiltrating growth pattern were the significant factors identified by univariate analysis. Only the invasive infiltrating growth pattern (OR3.44 p0.038) was selected as significant independent risk factor for peritoneal recurrence by multivariate analysis. In T1b / T2 patients, massive lymph node metastasis (N3a, 3b), scirrhous type were the significant factor for peritoneal recurrence by univariate analysis. Only massive lymph node metastasis (OR25.1 p<0.001) was selected as the significant independent risk factor by multivariate analysis. Conclusions: The incidence of peritoneal recurrence increases in proportion to the tumor depth. Invasive infiltrating growth pattern was selected as an independent risk factor for peritoneal recurrence in T3 patients, while it was massive lymph node metastasis in T1b / T2 patients. The results suggest the possibility that microscopic serosal invasion in T3 tumor and lymphatic progression in T1b / T2 tumor may contribute to peritoneal recurrence in gastric cancer.

Craniocaudal retroperitoneal node length as a risk factor for relapse from clinical stage I testicular germ cell tumor.

2014 ◽  
Vol 32 (4_suppl) ◽  
pp. 363-363 ◽  
Author(s):  
Stephanie Anne Holler Howard ◽  
Kathryn P. Gray ◽  
Elizabeth O'Donnell ◽  
Fiona M. Fennessy ◽  
Clair Beard ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Risk Factor ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Independent Risk Factor ◽  
Clinical Stage ◽  
Cell Tumor ◽  
Stage I ◽  
Risk Of Relapse

363 Background: To investigate if retroperitoneal craniocaudal nodal length (CCNL) or nodal volume (NV) predicts relapse risk in clinical stage I testicular cancer. Methods: This institutional review board-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant study retrospectively reviewed 826 patients with testicular cancer. One hundred eighteen out of 826 patients forming the analytic cohort had stage I disease and either more than or equal to 2 years surveillance or retroperitoneal lymph node dissection with no adjuvant chemotherapy. 3D NVs and CCNL were measured by two attending physicians in consensus. Association between relapse risk and CCNL/NV was evaluated using univariable/multivariable logistic regression analysis adjusted for known prognostic factors. Results: Sixty six out of 118 patients (56%) had nonseminomatous germ cell tumor (NSGCT) and 52 (44%) had seminomatous germ cell tumor (SGCT). Twenty one percent (25 out of 118) of patients relapsed: 24% (16 out of 66) for NSGCT and 17% (9 out of 52) for SGCT. Eighty percent of relapses were limited to the retroperitoneum; 90% of these were at the site of the largest lymph node. CCNL proved to be an independent risk factor in NSGCT using a multivariable logistic regression model adjusting for other potential known risk factors of embryonal predominance (EP) and lymphovascular invasion (LVI). For every 3 mm increase in CCNL, the risk of relapse increased by 52% (odds ratio [OR]=1.52; 95% CI=1.03- 2.25). For patients with SGCT, only the primary tumor size was an independent risk factor for relapse (OR=1.34; 95% CI=1.02-1.75). Conclusions: In NSGCT, CCNL was shown to be associated with increased risk of relapse independently of other known risk factors. If validated in a larger cohort, CCNL could provide important additional information used to inform management decisions in these patients.

Histological Mixed-Type Early Gastric Cancer Is an Independent Risk Factor for Lymph Node Metastasis: Presidential Poster

2015 ◽  
Vol 110 ◽  
pp. S1031
Author(s):  
Akinori Shimayoshi ◽  
Shunsuke Yamamoto ◽  
Shinjiro Yamaguchi ◽  
Kazuhiro Kozumi ◽  
Eiji Kimura ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Mixed Type ◽  
Independent Risk Factor ◽  
Node Metastasis

scholarly journals Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancer

2008 ◽  
Author(s):  
Yoshihiko Kitajima ◽  
Kazuma Ohtaka ◽  
Mayumi Mitsuno ◽  
Masayuki Tanaka ◽  
Seiji Sato ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Risk Factor ◽  
Independent Risk Factor ◽  
Helicobacter Pylori Infection

scholarly journals Clinical significance of controlling nutritional status score (CONUT) in evaluating outcome of postoperative patients with gastric cancer

2022 ◽  
Vol 12 (1) ◽  
Author(s):  
Qi Xiao ◽  
Xiaoqing Li ◽  
Baojun Duan ◽  
Xiaofan Li ◽  
Sida Liu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Regression Analysis ◽  
Risk Factor ◽  
Postoperative Complications ◽  
Nutritional Status ◽  
Independent Risk Factor ◽  
Multivariate Regression Analysis ◽  
Psychological Status ◽  
The Relationship ◽  
Conut Score

AbstractThe stomach is the main digestive organ in humans. Patients with gastric cancer often develop digestive problems, which result in poor nutrition. Nutritional status is closely related to postoperative complications and quality of life (QoL) in patients with gastric cancer. The controlling nutritional status (CONUT) score is a novel tool to evaluate the nutritional status of patients. However, the relationship of the CONUT score with postoperative complications, QoL, and psychological status in patients with gastric cancer has not been investigated. The present follow-up study was conducted in 106 patients who underwent radical gastrectomy in our hospital between 2014 and 2019. The CONUT score, postoperative complications, psychological status, postoperative QoL scores, and overall survival (OS) of patients with gastric cancer were collected, and the relationship between them was analyzed. A significant correlation was observed between the CONUT score and postoperative complications of gastric cancer (P < 0.001), especially anastomotic leakage (P = 0.037). The multivariate regression analysis exhibited that the CONUT score (P = 0.002) is an independent risk factor for postoperative complications. The CONUT score was correlated with the state anxiety questionnaire (S-AI) for evaluating psychological status (P = 0.032). However, further regression analysis exhibited that the CONUT score was not an independent risk factor for psychological status. Additionally, the CONUT score was associated with postoperative QoL. The multivariate regression analysis exhibited that the CONUT score was an independent risk factor for the global QoL (P = 0.048). Moreover, the efficiency of CONUT score, prognostic nutrition index, and serum albumin in evaluating complications, psychological status, and QoL was compared, and CONUT score was found to outperform the other measures (Area Under Curve, AUC = 0.7368). Furthermore, patients with high CONUT scores exhibited shorter OS than patients with low CONUT scores (P = 0.005). Additionally, the postoperative complications (HR 0.43, 95% CI 0.21–0.92, P = 0.028), pathological stage (HR 2.26, 95% CI 1.26–4.06, P = 0.006), and global QoL (HR 15.24, 95% CI 3.22–72.06, P = 0.001) were associated with OS. The CONUT score can be used to assess the nutritional status of patients undergoing gastric cancer surgery and is associated with the incidence of postoperative complications and QoL.

Loss of Lean Body Mass as an Independent Risk Factor for Continuation of S-1 Adjuvant Chemotherapy for Gastric Cancer

2014 ◽  
Vol 22 (8) ◽  
pp. 2560-2566 ◽  
Author(s):  
Toru Aoyama ◽  
Taiichi Kawabe ◽  
Hirohito Fujikawa ◽  
Tsutomu Hayashi ◽  
Takanobu Yamada ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Risk Factor ◽  
Adjuvant Chemotherapy ◽  
Lean Body Mass ◽  
Body Mass ◽  
Independent Risk Factor

scholarly journals Activation of the PX1/IL-1β axis in CD41+/CD62P+ platelets enhances pancreatic ductal adenocarcinoma invasion and metastasis

2021 ◽  
Author(s):  
Hao Li ◽  
Wang Jiang ◽  
Shirong Zhang ◽  
Huaxiang Xu ◽  
Pengcheng Li ◽  
...  
Keyword(s):  
Risk Factor ◽  
Pancreatic Ductal Adenocarcinoma ◽  
P38 Mapk ◽  
Tumor Invasion ◽  
Independent Risk Factor ◽  
Stage I ◽  
Ductal Adenocarcinoma ◽  
Invasion And Metastasis ◽  
Pdac Cell ◽  
Cell Malignancy

Abstract The pro-tumor mechanisms of platelets in pancreatic ductal adenocarcinoma (PDAC) are poorly understood. We showed that the count of the CD41+/CD62P + platelets subtype was significantly elevated in stage III/IV patients. An increased level of CD41+/CD62P + platelets could serve as an independent risk factor for stage I/II patients after surgery. Furthermore, we found significantly higher PX1 expression in CD41+/CD62P + platelets than in CD41+/CD62P- platelets in PDAC patients. Mechanistically, PX1 was able to enhance IL-1β secretion in platelets via phosphorylating p38 MAPK and consequently promoted PDAC invasion and metastasis. Finally, we constructed a novel compound named PC63435 by the ligation of carbenoxolone (PX1 inhibitor) and PSGL-1 (CD62P ligand). PC63435 specifically bound to CD41+/CD62P + platelets and blocked the PX1/IL-1β pathway, which suppressed PDAC tumor invasion and metastasis. Our findings revealed that the activation of PX1 in CD41+/CD62P + platelets enhanced PDAC cell malignancy and that may be a potent target for PDAC therapy.

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