Performance Improvement in Large-Scale MU-MIMO System with Multiple Antennas on User Side in a Single-Cell Downlink System

2020 ◽  
Vol 45 (8) ◽  
pp. 6769-6789
Author(s):  
Jagtar Singh ◽  
Deepak Kedia
Keyword(s):  
Single Cell ◽  
Performance Improvement ◽  
Large Scale ◽  
Mimo System ◽  
Multiple Antennas ◽  
Downlink System

scholarly journals FlsnRNA-seq: protoplasting-free full-length single-nucleus RNA profiling in plants

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Yanping Long ◽  
Zhijian Liu ◽  
Jinbu Jia ◽  
Weipeng Mo ◽  
Liang Fang ◽  
...  
Keyword(s):  
Single Cell ◽  
Cell Walls ◽  
Large Scale ◽  
Full Length ◽  
Cell Level ◽  
Root Cells ◽  
Rna Profiling ◽  
Different Types ◽  
Long Read ◽  
Single Nucleus

AbstractThe broad application of single-cell RNA profiling in plants has been hindered by the prerequisite of protoplasting that requires digesting the cell walls from different types of plant tissues. Here, we present a protoplasting-free approach, flsnRNA-seq, for large-scale full-length RNA profiling at a single-nucleus level in plants using isolated nuclei. Combined with 10x Genomics and Nanopore long-read sequencing, we validate the robustness of this approach in Arabidopsis root cells and the developing endosperm. Sequencing results demonstrate that it allows for uncovering alternative splicing and polyadenylation-related RNA isoform information at the single-cell level, which facilitates characterizing cell identities.

An Improved MMSE Pre-Coding Method for the Downlink Multi-User MIMO System

2012 ◽  
Vol 457-458 ◽  
pp. 600-606
Author(s):  
Xian Kun Gao ◽  
Yan Cui ◽  
Ji Lai Ying ◽  
Yong Chang Yu
Keyword(s):  
Numerical Simulations ◽  
Mimo System ◽  
Multiple Antennas ◽  
Poor Performance ◽  
Inversion Method ◽  
Block Diagonalization ◽  
Coding Method ◽  
Diagonalization Method ◽  
Noise Ratio ◽  
Theoretical Analyses

Recently many practical downlink multi-user MIMO linear pre-coding methods have been proposed, such as the channel inversion method and the block diagonalization method (BD). Considering the channel inversion method based on MMSE criterion (MMSE-CI) which is confined to a single receives antenna case, the BD has more advantages in multiple antennas cases, however, it has poor performance at the low and medium SNR regime on account of no consideration on the noise. In this paper, an improved MMSE pre-coding method is proposed with multi receive antennas of each user. Based on MMSE-CI, the cooperation of multiple antennas is adopted to further suppress the residual interference during designing the pre-coding matrix, which could increase the signal-to- interference-plus-noise ratio (SINR) at each user’s receiver. The proposed method obtains a better performance than the MMSE-CI and the BD algorithms, and its effectiveness is validated by both theoretical analyses and numerical simulations.

scholarly journals Cross-Layer Inference in WSN: From Methods to Experimental Validation

2020 ◽  
Author(s):  
Indrakshi Dey
Keyword(s):  
Mimo System ◽  
Hypothesis Test ◽  
Multiple Antennas ◽  
Statistical Signal Processing ◽  
Decision Fusion ◽  
Inference Problem ◽  
Robust Detection ◽  
Gas Leakage ◽  
Input Multiple Output ◽  
Set Up

In this chapter, the fundamentals of distributed inference problem in wireless sensor networks (WSN) is addressed and the statistical theoretical foundations to several applications is provided. The chapter adopts a statistical signal processing perspective and focusses on distributed version of the binary-hypothesis test for detecting an event as correctly as possible. The fusion center is assumed to be equipped with multiple antennas collecting and processing the information. The inference problem that is solved, primarily concerns the robust detection of a phenomenon of interest (for example, environmental hazard, oil/gas leakage, forest fire). The presence of multiple antennas at both transmit and receive sides resembles a multiple-input-multiple-output (MIMO) system and allows for utilization of array processing techniques providing spectral efficiency, fading mitigation and low energy sensor adoption. The problem is referred to as MIMO decision fusion. Subsequently, both design and evaluation (simulated and experimental) of these fusion approaches is presented for this futuristic WSN set-up.

scholarly journals Predicting heterogeneity in clone-specific therapeutic vulnerabilities using single-cell transcriptomic signatures

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Chayaporn Suphavilai ◽  
Shumei Chia ◽  
Ankur Sharma ◽  
Lorna Tu ◽  
Rafael Peres Da Silva ◽  
...  
Keyword(s):  
Single Cell ◽  
Large Scale ◽  
Drug Response ◽  
Drug Repurposing ◽  
High Accuracy ◽  
Molecular Heterogeneity ◽  
Precision Oncology ◽  
Scale Analysis ◽  
Rna Seq ◽  
Large Scale Analysis

AbstractWhile understanding molecular heterogeneity across patients underpins precision oncology, there is increasing appreciation for taking intra-tumor heterogeneity into account. Based on large-scale analysis of cancer omics datasets, we highlight the importance of intra-tumor transcriptomic heterogeneity (ITTH) for predicting clinical outcomes. Leveraging single-cell RNA-seq (scRNA-seq) with a recommender system (CaDRReS-Sc), we show that heterogeneous gene-expression signatures can predict drug response with high accuracy (80%). Using patient-proximal cell lines, we established the validity of CaDRReS-Sc’s monotherapy (Pearson r>0.6) and combinatorial predictions targeting clone-specific vulnerabilities (>10% improvement). Applying CaDRReS-Sc to rapidly expanding scRNA-seq compendiums can serve as in silico screen to accelerate drug-repurposing studies. Availability: https://github.com/CSB5/CaDRReS-Sc.

scholarly journals Leveraging high-powered RNA-Seq datasets to improve inference of regulatory activity in single-cell RNA-Seq data

2019 ◽  
Author(s):  
Ning Wang ◽  
Andrew E. Teschendorff
Keyword(s):  
Transcription Factors ◽  
Single Cell ◽  
Cell Fate ◽  
Regulatory Networks ◽  
Large Scale ◽  
Single Cells ◽  
Differential Expression Analysis ◽  
Dropout Rate ◽  
Rna Seq ◽  
Regulatory Activity

AbstractInferring the activity of transcription factors in single cells is a key task to improve our understanding of development and complex genetic diseases. This task is, however, challenging due to the relatively large dropout rate and noisy nature of single-cell RNA-Seq data. Here we present a novel statistical inference framework called SCIRA (Single Cell Inference of Regulatory Activity), which leverages the power of large-scale bulk RNA-Seq datasets to infer high-quality tissue-specific regulatory networks, from which regulatory activity estimates in single cells can be subsequently obtained. We show that SCIRA can correctly infer regulatory activity of transcription factors affected by high technical dropouts. In particular, SCIRA can improve sensitivity by as much as 70% compared to differential expression analysis and current state-of-the-art methods. Importantly, SCIRA can reveal novel regulators of cell-fate in tissue-development, even for cell-types that only make up 5% of the tissue, and can identify key novel tumor suppressor genes in cancer at single cell resolution. In summary, SCIRA will be an invaluable tool for single-cell studies aiming to accurately map activity patterns of key transcription factors during development, and how these are altered in disease.

scholarly journals Single-cell RNA counting at allele- and isoform-resolution using Smart-seq3

2019 ◽  
Author(s):  
Michael Hagemann-Jensen ◽  
Christoph Ziegenhain ◽  
Ping Chen ◽  
Daniel Ramsköld ◽  
Gert-Jan Hendriks ◽  
...  
Keyword(s):  
Single Cell ◽  
Large Scale ◽  
Cell Types ◽  
Mouse Strains ◽  
Rna Molecules ◽  
Counting Strategy ◽  
Long Read ◽  
Sequencing Strategy ◽  
Transcriptome Coverage ◽  
Scale Characterization

AbstractLarge-scale sequencing of RNAs from individual cells can reveal patterns of gene, isoform and allelic expression across cell types and states1. However, current single-cell RNA-sequencing (scRNA-seq) methods have limited ability to count RNAs at allele- and isoform resolution, and long-read sequencing techniques lack the depth required for large-scale applications across cells2,3. Here, we introduce Smart-seq3 that combines full-length transcriptome coverage with a 5’ unique molecular identifier (UMI) RNA counting strategy that enabled in silico reconstruction of thousands of RNA molecules per cell. Importantly, a large portion of counted and reconstructed RNA molecules could be directly assigned to specific isoforms and allelic origin, and we identified significant transcript isoform regulation in mouse strains and human cell types. Moreover, Smart-seq3 showed a dramatic increase in sensitivity and typically detected thousands more genes per cell than Smart-seq2. Altogether, we developed a short-read sequencing strategy for single-cell RNA counting at isoform and allele-resolution applicable to large-scale characterization of cell types and states across tissues and organisms.

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