Development of standardization parameters of crude drugs used in Ayurvedic Balarista formulation

2019 ◽  
Vol 19 (4) ◽  
pp. 455-467 ◽  
Author(s):  
Chandan Das ◽  
Anindya Bose ◽  
Subrata Mallick ◽  
Debajyoti Das
Keyword(s):  
Crude Drugs

Comparative Pharmacognostic, Physicochemical and Phytochemical Studies of Different Samples of Plumbago zeylanica L. Roots

2017 ◽  
Vol 9 (06) ◽  
Author(s):  
Neha Jain ◽  
Mohan Lal Kori
Keyword(s):  
Phytochemical Analysis ◽  
Local Market ◽  
Herbal Drugs ◽  
Disease Treatment ◽  
Organoleptic Evaluation ◽  
Plumbago Zeylanica ◽  
Qualitative And Quantitative ◽  
Crude Drugs ◽  
Phytochemical Studies

The objective of the present study is to evaluate the quality of the marketed and self collected samples of Plumbago zeylanica L. roots on the standardization parameters. This study is planned mainly to confirm changes with quality of drug. Now a day’s more demand of herbal drugs for disease treatment, lack of knowledge of proper methodology and availability are promoting the practices of adulteration and substitution. Thus, the standardization of the plant crude drugs is necessary to maintain their therapeutic efficacy. Comparative studies were carried out to evaluate the standards of P. zeylanica L. with emphasis on organoleptic evaluation, physicochemical and phytochemical analysis. Samples were procured from local market and self collected to determine the qualitative and quantitative variations. The result indicates that self collected sample showed significant results with comparison to marketed sample.

Pharmacognostical fingerprinting and selective bioactivity studies of Solanum glaucophyllum Desf.

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
Anindya Sundar Ray ◽  
Suman Kalyan Mandal ◽  
Chowdhury Habibur Rahaman
Keyword(s):  
Medicinal Plant ◽  
Radical Scavenging ◽  
Ethanol Extract ◽  
Inhibition Zone ◽  
Phytochemical Analysis ◽  
Antimicrobial Studies ◽  
Maximum Inhibition ◽  
Crude Drugs ◽  
Phytochemical Studies ◽  
Dpph Radical Scavenging

Solanum glaucophyllum Desf. (Solanaceae) is traditionally used for curing several health conditions in both human and domesticated animals. There is no data available regarding pharmacognostic standardization and pharmacological activity of this less known medicinal plant. Therefore, the aim of the present work is to prepare pharmacognostic fingerprints of crude drugs obtained from the leaf and stem parts of S. glaucophyllum. Apart from this detailed phytochemical analysis, antioxidant and antimicrobial studies have also been carried out. Pharmacognostic study revealed that the leaves are amphistomatic and stomata are strictly of anisocytic type. Values of stomatal index, palisade ratio, ash content of the investigated parts are found distinct and can be used as pharmacognostic standards for evaluation of crude drugs of this medicinal plant. Phytochemical studies of the leaf and stem parts indicated that phenolics, flavonoids, tannins and alkaloids are present in quite impressible amount. Curcumin content in stem was found very high through HPLC analysis. In DPPH radical scavenging assay, the stem part showed significant antioxidant potential. Ethanol extract of stem produced maximum inhibition zone (11mm) against Pseudomonas aeruginosa at the concentration of 50 mg/ml among five test microorganisms. Some pharmacognostic features recorded in this study as diagnostic ones will help in proper identification of this ethnomedicinal plant in its fresh as well as dried form. On the other hand preliminary phytochemical, antioxidant and antimicrobial studies highlight the S. glaucophyllum as a promising candidate for bioprospecting.

Comparative Pharmacognostical Evaluation of Khadirashtaka yavakuta (Powder) and Kashaya (Decoction)

2017 ◽  
Vol 9 (10) ◽  
Author(s):  
Chandani Goswami ◽  
V. D. Hitesh Vyas ◽  
Harisha C. R.
Keyword(s):  
Dietary Habits ◽  
Prolonged Exposure ◽  
Skin Diseases ◽  
Metabolic Changes ◽  
Skin Disorders ◽  
Coarse Powder ◽  
Crude Drugs ◽  
Standard Range

Khadirashtaka Kashaya, a compound Ayurvedic formulation is prescribed mainly in the management of Kushtha Vyadhi( skin diseases), Visarp Roga (erysipelous) and Masoorika (type of measels) and it is mentioned in Sangraha Grantha like, Yogaratnakara, Gadanighraha, Bhaishajya Ratnavali. The era is rising with many of novel dietary habits and lifestyle which are ill-assorted with health. Consumption of incompatible food combinations, heavy meals; faulty temperature acclimatisation leads to several metabolic changes which results in unhealthy skin. Their prolonged exposure leads to long lasting dermatological abnormalities having vitiated Rasa and Rakta Dhatu. Khadirashtaka Kashaya helps to break the pathogenesis of skin disorders by its bitter-astringent taste, light and dry properties as well as blood purifying activity. Till date no work was found having comparatively scientifically analysed on this drug. In Present study Khadirashtaka Kashaya and Khadirashtaka choorna have been evaluated for Pharmacognostical analysis. Finished product microscopy and decoction showing the quality and genuineness of all the constituents of Khadirashtaka Kashaya (Decoction) has been done. Organoleptic features of coarse powder made out of the crude drugs were within the standard range

scholarly journals Minute Constituents of Crude Drugs. VIII

1955 ◽  
Vol 75 (1) ◽  
pp. 83-85 ◽  
Author(s):  
Takeshi Watanabe
Keyword(s):  
Crude Drugs

The Pharmacological and Pathological Studies on Taiwan Folk Medicine (VI): The Effects of Elephantopus scaber subsp. oblanceolata, E. mollis and Pseudoelephantopus spicatus

1991 ◽  
Vol 19 (01) ◽  
pp. 41-50 ◽  
Author(s):  
Chun-Ching Lin ◽  
Ming-Hong Yen ◽  
Hui-Fen Chiu
Keyword(s):  
Protective Effect ◽  
Liver Enzyme ◽  
Folk Medicine ◽  
Serum Transaminase ◽  
Functional Test ◽  
Fatty Metamorphosis ◽  
Elephantopus Scaber ◽  
Acute Increase ◽  
Crude Drugs

The liver protective effect of Elephantopus scaber subsp. oblanceolata, E. mollis and Pseudoelephantopus spicatus on CCL 4 induced hepatotoxicity has been determined by liver enzyme functional test and pathological studies. As the result indicatep, the acute increase of serum transaminase (SGOT and SGPT level which was caused by CCL 4 administration (3.0ml/kg, s.c.) can be significantly reduced when treating with E. scaber subsp. oblanceolata( p < 0.001), E. mollis( p < 0.01), P. spicatus( p < 0.01). The hepatic fatty metamorphosis and necrosis of central lobule were obviously improved by treating with E. scaber subsp. oblanceolata and E. mollis, while treated with P. spicatus demonstrated only a moderate protective effect. All pharmacological and pathological effects of these three crude drugs were compared with Bupleurum chinense which has been reported previously as a treatment criteria.

scholarly journals Purification, Preliminary Characterization, and Immunological Activity of Polysaccharides from Crude Drugs of Sijunzi Formula

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Yunfei Ji ◽  
Ruijun Wang ◽  
Ying Peng ◽  
Chongsheng Peng ◽  
Xiaobo Li
Keyword(s):  
Monosaccharide Composition ◽  
Raw 264.7 Cells ◽  
No Production ◽  
Inhibitory Effects ◽  
Immunological Activity ◽  
Spleen Deficiency ◽  
Radix Glycyrrhizae ◽  
Crude Drugs ◽  
The Complement System ◽  
Necrosis Factor

Sijunzi Decoction (SJZD) is a conventional prescription for curing spleen deficiency in Traditional Chinese Medicine and polysaccharide is its main ingredient. In order to explore the effective ingredients contributing to the immunological activity of SJZD, we isolated and purified seven homogeneous polysaccharides from Radix Ginseng (RS-3-1 and RS-3-2), Rhizoma Atractylodis Macrocephalae (BZ-3-1, BZ-3-2, and BZ-3-3), Poria (FL-3-1), and Radix Glycyrrhizae (GC-3-1) decoctions, respectively. The molecular weight of seven homogeneous polysaccharides ranged from 5.42 × 104 to 5.65 × 104 Da. Monosaccharide composition determined by GC-MS analysis showed that these polysaccharides were primarily composed of Rha, Ara, Xyl, Man, Glc, and Gal with various ratios. Immunological activity assay revealed that polysaccharides from four crude drug components of SJZD displayed inhibitory effects on the complement system. RS-3-1, BZ-3-1, FL-3-1, and GC-3-1 could significantly enhance the phagocytosis and increase the NO production and tumor necrosis factor (TNF-α) level in RAW 264.7 cells (p<0.05). These results demonstrated the immunological activities of these polysaccharides from the four crude drugs. This study supports the therapeutic effect of SJZD in clinical use and is essential for further identification the immunopolysaccharide from SJZD decoction.

scholarly journals Evaluation of macro and microminerals in crude drugs and infusions of five herbs widely used as sedatives

2011 ◽  
Vol 21 (6) ◽  
pp. 1144-1149 ◽  
Author(s):  
Marta E. Petenatti ◽  
Elisa M. Petenatti ◽  
Luis A. Del Vitto ◽  
Mauricio R. Téves ◽  
Néstor O. Caffini ◽  
...  
Keyword(s):  
Crude Drugs

Primary Phytochemical Evaluation of P. oleracea and P. quadrifida

2021 ◽  
pp. 3789-3793
Author(s):  
T. P. Dugawale ◽  
C.C. Khanwelkar ◽  
P.P. Durgawale
Keyword(s):  
Quality Assurance ◽  
Extraction Techniques ◽  
Quality Assurance Procedure ◽  
Closely Related Species ◽  
Recent Interest ◽  
Percentage Yield ◽  
Crude Drugs ◽  
Primary Evaluation ◽  
Layer Chromatography

P. oleracea and P. quadrifida are closely related species belonging to family Portulaceae. They are found in almost parts of the globe growing as neglected weed. However, recent interest in these plants owing to their palatable sour taste and health benefits have made them acceptable as cultivable plants and potted herbs. Even though numerous studies indicate the presence of pharmacological compounds in these plants, reports on quality assurance practices followed for evaluating these plants as crude drugs have not been detailed. In this study, the plant species were harvested as weed, authenticated, extracted using different solvents and extraction techniques. The extracts were then evaluated and studied for their primary phytochemical composition. This was followed by isolation of beta sitosterol using thin layer chromatography and column chromatography. The results indicate the presence all major classes of phytochemicals such as steroids, flavanoids, alkaloids, saponins, polysaccharides, and tannins. The percentage yield, extractive values, ash values, moisture content were calculated for both the species. The isolation of beta-sitosterol may be used as a quality assurance procedure. The data presented in this study may be further used by researchers for primary evaluation of quality of crude drugs in the form of P. oleracea and P. quadrifida plants.

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