The Pharmacological and Pathological Studies on Taiwan Folk Medicine (VI): The Effects of Elephantopus scaber subsp. oblanceolata, E. mollis and Pseudoelephantopus spicatus

The liver protective effect of Elephantopus scaber subsp. oblanceolata, E. mollis and Pseudoelephantopus spicatus on CCL 4 induced hepatotoxicity has been determined by liver enzyme functional test and pathological studies. As the result indicatep, the acute increase of serum transaminase (SGOT and SGPT level which was caused by CCL 4 administration (3.0ml/kg, s.c.) can be significantly reduced when treating with E. scaber subsp. oblanceolata( p < 0.001), E. mollis( p < 0.01), P. spicatus( p < 0.01). The hepatic fatty metamorphosis and necrosis of central lobule were obviously improved by treating with E. scaber subsp. oblanceolata and E. mollis, while treated with P. spicatus demonstrated only a moderate protective effect. All pharmacological and pathological effects of these three crude drugs were compared with Bupleurum chinense which has been reported previously as a treatment criteria.

Download Full-text

The Pharmacological and Pathological Studies on Several Hepatic Protective Crude Drugs from Taiwan (I)

The American Journal of Chinese Medicine ◽

10.1142/s0192415x88000194 ◽

1988 ◽

Vol 16 (03n04) ◽

pp. 127-137 ◽

Cited By ~ 18

Author(s):

Hui-Fen Chiu ◽

Chun-Ching Lin ◽

Chui-Ching Yang ◽

Fay Yang

Keyword(s):

Carbon Tetrachloride ◽

Protective Effect ◽

Liver Enzyme ◽

Inflammatory Cell ◽

Fatty Degeneration ◽

Enzyme Function ◽

Central Vein ◽

Fatty Metamorphosis ◽

Function Test ◽

Crude Drugs

This study is to investigate hepatic protective effect of several Taiwan crude drug extractions on the carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. The pharmacological and pathological effects of Bupleurm chinense, Phellodendron wilsonii, Clematis chinensis and Hedyotis corymbosa were analyzed by liver enzyme function test and pathological studies. However, the results of amine transferase SGOT and SGPT have shown a significant hepatic protective effect after treatment with Bupleurm chinense (P<0.005), Phellodendron wilsonii (P<0.001), Clematis chinensis (P<0.005) and Hedyotis corymbosa (P<0.005, SGPT only). The fatty degeneration around the central vein area and necrosis of the central lobule can be significantly improved by P. wilsonii and moderately changed by B. chinense or C. chinensis. Although fatty metamorphosis has been affected by H. corymbosa various inflammatory cell infiltrations in the cytoplasm were noted.

Download Full-text

The Pharmacological and Pathological Studies on Several Hepatic Protective Crude Drugs from Taiwan (II)

The American Journal of Chinese Medicine ◽

10.1142/s0192415x89000048 ◽

1989 ◽

Vol 17 (01n02) ◽

pp. 17-23 ◽

Cited By ~ 16

Author(s):

Hui-Fen Chiu ◽

Chun-Ching Lin ◽

Chui-Ching Yang ◽

Fay Yang

Keyword(s):

Protective Effect ◽

Protective Action ◽

Histopathological Change ◽

Solanum Incanum ◽

Gardenia Jasminoides ◽

Fatty Metamorphosis ◽

Entire Plant ◽

Acute Increase ◽

Effect Of Treatment ◽

Moderate Change

Four crude drug extracts of Solanum incanum (entire plant), Ixeris chinensis (entire plant), Gardenia jasminoides (wild and cultivated, fructus) were adminstered to rats as dose of 1.0 g/kg, I.P. injection to screen the liver protective effect on CC14 induced hepatotoxicity. The acute increase of transaminase SGOT and SGPT levels that was caused by CC14 (1.0 ml/kg) S.C. injection can be significantly improved when treated with Solanum incanum( p <0.005), Ixeris chinensis( p <0.001), Gardenia jasminoides (cultivated) ( p <0.005) but only a moderate change was shown by means of wild Gardenia jasminoides( p <0.05). As our results indicated, the extraction of these drugs has been found to possess a marked hepatic protective effect. The hepatic fatty metamorphosis and necrosis of central lobule were obviously improved by S. incanum and .I. chinesis administration, while the effect of treatment with G. jasminoides (cultivated) demonstrated a moderate protective action and little histopathological change by G. jasminoides (wild). In contrast to B. chinese, which has been reported previously as a treatment criteria, the S. incanum( p <0.01) and I. chinensis( p <0.01) in the present study has indicated that a significantly different hepatic protective effect on CC14 induced hepatic injury.

Download Full-text

Studies on Folk Medicine "Thang-kau-tin" from Taiwan (I) The Anti-inflammatory and Liver-protective Effect

The American Journal of Chinese Medicine ◽

10.1142/s0192415x92000059 ◽

1992 ◽

Vol 20 (01) ◽

pp. 37-50 ◽

Cited By ~ 11

Author(s):

Chun-Ching Lin ◽

Jer-Min Lin ◽

Hui-Fen Chiu

Keyword(s):

Folk Medicine ◽

Central Vein ◽

Pathological Changes ◽

Paw Edema ◽

Cell Necrosis ◽

Fatty Change ◽

Acute Increase ◽

Crude Drugs ◽

Anti Inflammatory ◽

Mallotus Repandus

Five species of crude drugs are used as "Thang-kau-tin" on Taiwan market: (1) the stem of Mallotus repandus (Willd.) Muell. -Arg, (2) the stem and root of M. repandus (Willd.) Muell. -Arg, (3) the stem of Bauhinia championii Benth, (4) the stem with hooks of Uncaria hirsuta Haviland and (5) the stem with hooks of U. rhynchophylla Miquel. To clarify the effect of these crude drugs as anti-inflammatory and liver-protective agents, studies were conducted on water extracts of these five crude drugs. The statistical analysis (ANOVA) indicated that the stem of M. repandus showed the best anti-inflammatory activity against the paw edema induced by carrageenan. Nevertheless, the acute increase of GOT and GPT levels caused by CCl 4 were markedly decreased by the treatment of M. repandus (stem), B. championii and U. hirsuta as a recipe group. The pathological changes around the central vein including fatty change, ballooning degeneration, cell necrosis, the increase in lymphocytes and Kupffer cells were improved by the treatment with the group of crude drugs as mentioned above.

Download Full-text

The Pharmacological and Pathological Studies on Taiwan Folk Medicine (IV)

The American Journal of Chinese Medicine ◽

10.1142/s0192415x90000150 ◽

1990 ◽

Vol 18 (03n04) ◽

pp. 113-120 ◽

Cited By ~ 11

Author(s):

Chun-Ching Lin ◽

Ming-Hong Yen ◽

Hui-Fen Chiu ◽

Cheng-Hsiung Chang

Keyword(s):

Protective Effect ◽

Folk Medicine ◽

Hepatoprotective Effect ◽

Functional Disorder ◽

Crude Drug ◽

Hepatocyte Necrosis

The protective effect of "San-fang-feng" derived from the root of Echinops grijisii Hance on CCI4-induced hepatotoxicity has been studied. This crude drug was found to possess a marked hepatoprotective effect. A comparison of the protective effect with "Lou-lu" derived from the root of E. latifolius Tausch and "Pei-chai-hu" oringinal Bupleurum chinese showed that E. grijisii and E. latifolius were more effective than chinese as reported previously. The results suggested that both E. grijisii and E. latifolius could correct the hepatocyte necrosis and functional disorder induced by the CCI4 treatment.

Download Full-text

The Pharmacological and Pathological Studies on Taiwan Folk Medicine (VII): The Anti-inflammatory Effect of Echinops grjiisii

The American Journal of Chinese Medicine ◽

10.1142/s0192415x92000138 ◽

1992 ◽

Vol 20 (02) ◽

pp. 127-134 ◽

Cited By ~ 9

Author(s):

Chun-Ching Lin ◽

Cheng-hung Lin ◽

Hui-Fen Chiu ◽

Min-Fu Hu

Keyword(s):

Methanolic Extract ◽

Folk Medicine ◽

Animal Experiments ◽

Active Principle ◽

Chloroform Fraction ◽

Protective Effects ◽

Active Components ◽

Crude Drugs ◽

Anti Inflammatory ◽

Inflammatory Effect

The hepatotoxic-protective effects of "San-fang-feng" (the root of E. grijisii) and "Lou-lu" (the root of E. latifolius) on CCl 4 induced hepatotoxicity have been proposed in our previous paper (Lin et al, 1990). The anti-inflammatory effects of these two crude drugs were investigated in this experiment. The results indicated that both of them displayed pronounced anti-inflammatory activities against carrageenan-induced edema. Furthermore, in order to isolated the main active components of E. grijisii, fractions obtained from the methanolic extract of E. grijisii were investigated in mice for their 24-h LD 50 and 95% confidence limits, which could be used as a guiding for further animal experiments. Our findings demonstrated that n-hexane (100,300 mg/kg), chloroform (30,100,300 mg/kg) and ethyl acetate (30,100, 300 mg/kg) fractions could markedly inhibit the carrageenan-induced inflammation, and the main active principle was found to be concentrated in the chloroform fraction, which possessed significant inhibitory activities even more than does indomethacin.

Download Full-text

Metabolomic Profiling of Mango (Mangifera indica Linn) Leaf Extract and Its Intestinal Protective Effect and Antioxidant Activity in Different Biological Models

Molecules ◽

10.3390/molecules25215149 ◽

2020 ◽

Vol 25 (21) ◽

pp. 5149

Author(s):

Roberto O. Ybañez-Julca ◽

Daniel Asunción-Alvarez ◽

Ivan M. Quispe-Díaz ◽

Javier Palacios ◽

Jorge Bórquez ◽

...

Keyword(s):

Oxidative Stress ◽

Antioxidant Activity ◽

Protective Effect ◽

High Performance ◽

Mangifera Indica ◽

Folk Medicine ◽

In Vitro Assays ◽

Antispasmodic Activity ◽

Intestinal Segments

Mangifera indica Linn popularly known as mango is used in folk medicine to treat gastrointestinal disorders. The aim of this study was to identify the metabolomic composition of lyophilized extract of mango leaf (MIE), to evaluate the antioxidant activity on several oxidative stress systems (DPPH, FRAP, TBARS, and ABTS), the spasmolytic and antispasmodic activity, and intestinal protective effect on oxidative stress induced by H2O2 in rat ileum. Twenty-nine metabolites were identified and characterized based on their ultra-high-performance liquid chromatography (UHPLC) high-resolution orbitrap mass spectrometry, these include: benzophenone derivatives, xanthones, phenolic acids, fatty acids, flavonoids and procyanidins. Extract demonstrated a high antioxidant activity in in-vitro assays. MIE relaxed (p < 0.001) intestinal segments of rat pre-contracted with acetylcholine (ACh) (10−5 M). Pre-incubation of intestinal segments with 100 µg/mL MIE significantly reduced (p < 0.001) the contraction to H2O2. Similar effects were observed with mangiferin and quercetin (10−5 M; p < 0.05) but not for gallic acid. Chronic treatment of rats with MIE (50 mg/kg) for 28 days significantly reduced (p < 0.001) the H2O2-induced contractions. MIE exhibited a strong antioxidant activity, spasmolytic and antispasmodic activity, which could contribute to its use as an alternative for the management of several intestinal diseases related to oxidative stress.

Download Full-text

Studies on Chemical Protectors against Radiation. XXVI. Protective Effect of Various Extracts on Crude Drugs on Skin Injury Induced by X-Irradiation

YAKUGAKU ZASSHI ◽

10.1248/yakushi1947.109.2_113 ◽

1989 ◽

Vol 109 (2) ◽

pp. 113-118 ◽

Cited By ~ 4

Author(s):

Yushi SATO ◽

Setsuko OHTA ◽

Nobuko SAKURAI ◽

Masato SHINODA

Keyword(s):

Protective Effect ◽

Skin Injury ◽

X Irradiation ◽

Crude Drugs

Download Full-text

Medicinal Properties of Flavonoids: الفلافونويدات وخواصها الدوائية

Journal of medical and pharmaceutical sciences - مجلة العلوم الطبية و الصيدلانية ◽

10.26389/ajsrp.h020919 ◽

2019 ◽

Vol 3 (4) ◽

Author(s):

Hasan M. H. Muhaisen, Esraa M. M. Ali

Keyword(s):

Protective Effect ◽

Folk Medicine ◽

Epidemiological Studies ◽

Biological Properties ◽

Antioxidant Effect ◽

Present Review ◽

Isolation And Identification ◽

Active Constituents ◽

Antitumour Agents ◽

Positive Effects

Flavonoids are ubiquitous in photosynthesizing cells and are commonly found in fruit, vegetables, nuts, seeds, stems, flowers, tea, and honey. Therefore, a significant quantity is consumed in our daily diet. These flavonoids are variously associated with the sensory and nutritional quality of our plant foods. For centuries, preparations containing these compounds as the principal physiologically active constituents have been used to treat human diseases. There has been increasing interest in the research on flavonoids from plant sources because of their versatile health benefits reported in various epidemiological studies. Since flavonoids are directly associated with human dietary ingredients and health, there is need to evaluate structure and function relationship. There have been many bioassay guided searches for cytotoxic antitumour agents in plants especially those known to be used in folk medicine for this purpose. This has led to the isolation and identification of quite a large number of active constituents from all the different flavonoid classes, e.g. catechins, flavans, dihydrochalcones, chalcones, flavanones, dihydro-flavonols, flavones, biflavonoids and flavonol. The purpose of the present review is to discuss recent developments in the biochemistry and medicinal aspects of the flavonoids. Flavonoids have received a lot of interest in scientific research over the past 20 years and have had many beneficial and potential effects. Flavonoids have many great advantages as natural compounds compared to therapeutic agents because many diets are rich in polyphenols and are consumed daily and are easily absorbed in the intestines after ingestion, especially flavonoids, have positive effects on health: antioxidants, lethargy, allergies and bacteria, And cancer. The protective effect of flavonoids is primarily due to its antioxidant effect and inhibition of enzymes. The protective effect of flavonoids from diseases is mainly due to their antioxidant effect. Recent research on the biological properties of flavonoids will therefore be a further subject of the present review.

Download Full-text

Gastroprotective Effects of Methanolic Leaves and Stem Extracts of Sphagneticola trilobata on Indomethacin-Induced Gastric Ulcer in Rats

Asian Journal of Chemistry ◽

10.14233/ajchem.2022.23440 ◽

2021 ◽

Vol 34 (1) ◽

pp. 111-117

Author(s):

Kartik Singhal ◽

Chandana Majee ◽

Bhavani Pentela ◽

Vikas Sharma

Keyword(s):

Gastric Ulcer ◽

South America ◽

Medicinal Plant ◽

Protective Effect ◽

Folk Medicine ◽

Gastric Ulcers ◽

Control Group ◽

Methanolic Extracts ◽

Neutrophil Percentage ◽

Stem Extract

The medicinal plant Sphagneticola trilobata native to South America is used in local folk medicine to treat inflammation and analgesics. In present study, gastroprotective effects of methanolic extracts of S. trilobata leaves and stem were investigated in indomethacin-induced gastric ulcers in rats at doses of 200 mg/kg for leave extract and 350 mg/kg for stem extract. Indomethacin produced stomach ulcers and increased neutrophil percentage and MDA levels compared to the control group (p < 0.001). Co-administration of indomethacin and omeprazole, methanolic extracts of leaves (200 mg/kg) (p < 0.001) and methanolic extracts (350 mg/kg) (p < 0.05) of stem compared to indomethacin group to ulcers was low (p < 0.001). Methanolic extracts (200 mg/kg) of leaves and methanolic extracts (350 mg/kg) of stem reduced MDA levels (p < 0.001). Methanolic extracts (200 mg/kg) of leaves and methanolic extracts (350 mg/kg) of the stem significantly decreased neutrophil percentage compared to indomethacin group (p < 0.001). The results suggest that the methanolic extracts of Sphagneticola trilobata leaves and stem have a protective effect on indomethacin-induced gastric ulcers.

Download Full-text