Micelles of polylactide–poly(ethylene glycol)–polylactide (LA n –EG m –LA n ) triblock copolymers as insulin delivery system: spectroscopic studies

2017 ◽  
Vol 14 (12) ◽  
pp. 2637-2648 ◽  
Author(s):  
Pouneh Sadat Pourhosseini ◽  
Reza Amani ◽  
Ali Akbar Saboury ◽  
Farhood Najafi ◽  
Mohammad Imani
Keyword(s):  
Ethylene Glycol ◽  
Delivery System ◽  
Triblock Copolymers ◽  
Insulin Delivery ◽  
Spectroscopic Studies ◽  
Poly Ethylene Glycol ◽  
Insulin Delivery System ◽  
Poly Ethylene

Synthesis and self-assembly behaviour of poly(Nα-Boc-l-tryptophan)-block-poly(ethylene glycol)-block-poly(Nα-Boc-l-tryptophan)

RSC Advances ◽  
2016 ◽  
Vol 6 (29) ◽  
pp. 24142-24153
Author(s):  
Andreea S. Voda ◽  
Kevin Magniez ◽  
Nisa V. Salim ◽  
Cynthia Wong ◽  
Qipeng Guo
Keyword(s):  
Drug Delivery ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Triblock Copolymers ◽  
Potential Drug ◽  
Poly Ethylene Glycol ◽  
Drug Delivery Applications ◽  
Poly Ethylene ◽  
First Time

We report for the first time the use of Nα-Boc-l-tryptophan for the synthesis of amphiphilic BAB triblock copolymers for potential drug delivery applications.

A smart drug-delivery nanosystem based on carboxylated graphene quantum dots for tumor-targeted chemotherapy

Nanomedicine ◽  
2019 ◽  
Vol 14 (15) ◽  
pp. 2011-2025 ◽  
Author(s):  
Zhen Li ◽  
Jialong Fan ◽  
Chunyi Tong ◽  
Hongyan Zhou ◽  
Wenmiao Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Quantum Dots ◽  
Folic Acid ◽  
Ethylene Glycol ◽  
Drug Delivery System ◽  
Delivery System ◽  
Graphene Quantum Dots ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Aim: Constructing a new drug-delivery system using carboxylated graphene quantum dots (cGQDs) for tumor chemotherapy in vivo. Materials & methods: A drug-delivery system was synthesized through a crosslink reaction of cGQDs, NH2-poly(ethylene glycol)-NH2 and folic acid. Results: A drug delivery system of folic acid-poly(ethylene glycol)-cGQDs was successfully constructed with ideal entrapment efficiency (97.5%) and drug-loading capacity (40.1%). Cell image indicated that the nanosystem entered into human cervical cancer cells mainly through macropinocytosis-dependent pathway. In vivo experiments showed the outstanding antitumor ability and low systemic toxicity of this nanodrug-delivery system. Conclusion: The newly developed drug-delivery system provides an important alternative for tumor therapy without causing systemic adverse effects.

Perfluoropolyether/poly(ethylene glycol) triblock copolymers with controllable self-assembly behaviour for highly efficient anti-bacterial materials

RSC Advances ◽  
2015 ◽  
Vol 5 (79) ◽  
pp. 64170-64179 ◽  
Author(s):  
Jing Song ◽  
Qun Ye ◽  
Wang Ting Lee ◽  
Xiaobai Wang ◽  
Tao He ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Self Assembly ◽  
Click Reaction ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Highly Efficient ◽  
Poly Ethylene ◽  
High Yields

A series of perfluoropolyether/poly(ethylene glycol) (PFPE/PEG) triblock copolymers PEG/PFPE/PEG (P1–P3) and PFPE/PEG/PFPE (P4–P5) were prepared via thiol–ene click reaction in high yields.

Thermogelation Properties of ABA Triblock Copolymers of Poly(Ethylene Glycol) (B) and Copolyacrylates of Oligo(Ethylene Glycol)s (A) in Aqueous Solution

2013 ◽  
Vol 11 (2) ◽  
pp. 149-156 ◽  
Author(s):  
Ioana Negru ◽  
Mircea Teodorescu ◽  
Paul O. Stănescu ◽  
Constantin Drăghici ◽  
Anamaria Lungu ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Ethylene Glycol ◽  
Triblock Copolymers ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

A Poly(β-Amino Ester) of Spermine and Poly(ethylene Glycol) Diacrylate as a Gene Carrier

2007 ◽  
Vol 342-343 ◽  
pp. 425-428 ◽  
Author(s):  
Dhananjay Jere ◽  
Tae Hee Kim ◽  
Rohidas B. Arote ◽  
Hu Lin Jiang ◽  
Myung Haing Cho ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Ethylene Glycol ◽  
Delivery System ◽  
Transfection Efficiency ◽  
Water Soluble ◽  
Gene Carrier ◽  
Gene Delivery System ◽  
Poly Ethylene Glycol ◽  
Wide Range ◽  
Poly Ethylene

Vectors are vital aspect of gene delivery system which decides the success of gene therapy. Efficient transfection with minimum or no toxicity, are two principal aims of any gene delivery system. In this our study, we rationally developed biodegradable water soluble poly(ßamino ester) (PAE) based on spermine (SPR) and poly (ethylene glycol) (PEG), by Michael-type addition reaction and further studied for its potential as a gene carrier. Confirmation of synthesized PAE was done by proton NMR spectroscopy. In gel retardation assay, the PAEs have shown good DNA binding ability over wide range of polyplexes. The addition of PEG over SPR resulted in a novel PAE with higher degree of safety and transfection efficiency as compared with polyethylenimine 25K (PEI) when studied in 293T human kidney carcinoma cells.

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