Plasma levels of soluble urokinase plasminogen activator receptor (suPAR) and high-sensitivity C-reactive protein after Roux-en-Y gastric bypass or sleeve gastrectomy: a 1-year prospective observational study

2020 ◽  
Author(s):  
A. Kokkinos ◽  
C. Liaskos ◽  
K. Alexiadou ◽  
I. Papassotiriou ◽  
A. Margeli ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Observational Study ◽  
Plasma Levels ◽  
Prospective Observational Study ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Urokinase Plasminogen Activator Receptor ◽  
Reactive Protein ◽  
Plasminogen Activator Receptor

scholarly journals IMPACT OF BARIATRIC SURGERY ON THE INFLAMMATORY STATE BASED ON CPR VALUE

2018 ◽  
Vol 31 (4) ◽  
Author(s):  
Renato MIGLIORE ◽  
João Kleber Almeida GENTILE ◽  
Fabiana Tornincasa FRANCA ◽  
Guilherme Tommasi KAPPAZ ◽  
Pedro Marcos Santinho BUENO-DE-SOUZA ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Observational Study ◽  
Inflammatory Mediators ◽  
Surgical Procedure ◽  
Prospective Observational Study ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Inflammatory State ◽  
Gastric By Pass

ABSTRACT Background: PCR (C-reactive protein), produced in the liver after stimuli of inflammatory mediators, is determined as a marker of inflammatory activity (adipocytokines) and is present within adipocyte cells; besides being an inflammatory product, many studies have shown to be a predictor of complications. Aim: To determine if the inflammatory state of the obese patient decreases after bariatric surgery, based on pre and post-operative PCR. Methods: A prospective, observational study in patients undergoing Roux-en-Y gastric by-pass surgery followed up for three months after surgery, with serum preoperative CRP in 30, 60 and 90 days after surgery. Results: A total of 19 patients, who had a mean CRP value before the surgical procedure of 0.80(±0.54) mg/dl, were followed, and when compared to the CRP with 30 days of surgery, they presented a significant increase to 2.68 mg/dl (p=0.012). When compared with the PCR of 60 days after the surgical procedure, it was also higher with the value of 3.32 mg/dl (p=0.27). However, at three months after surgery, the CRP showed a decrease when compared to the preoperative mark, with value of 0.45 mg/dl (p=0.0042). Conclusion: Roux-en-Y gastric bypass was able to decrease the chronic inflammation status of these patients, based on the value of CRP, with three months of surgery.

scholarly journals Soluble Urokinase Plasminogen Activator Receptor and the Risk of Coronary Artery Disease in Young Chinese Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Yuli Huang ◽  
Haobin Zhou ◽  
Yu Wu ◽  
You Yang ◽  
Wensheng Li ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Risk Factor ◽  
Coronary Artery ◽  
High Sensitivity ◽  
Chinese Patients ◽  
C Reactive Protein ◽  
Urokinase Plasminogen Activator Receptor ◽  
Reactive Protein ◽  
Plasminogen Activator Receptor ◽  
Artery Disease

Background. Soluble urokinase plasminogen activator receptor (suPAR) is a novel marker of chronic inflammation and is considered to be a risk factor for coronary artery disease (CAD) in Caucasians. This study investigated the role of suPAR in young Chinese patients with CAD.Methods. The study involved a total of 196 consecutive young (age ≤ 55 years) patients with angiographically proven CAD and 188 age-matched non-CAD individuals as controls. Traditional risk factors were evaluated using conventional assays, and levels of suPAR were measured by sandwich enzyme-linked immunosorbent assays.Results. Levels of suPAR were significantly correlated with age (r=0.20,P=0.04), smoking (r=0.33,P=0.008), body mass index (r=0.21,P=0.03), and high-sensitivity C-reactive protein (hs-CRP;r=0.31,P=0.01). Multivariate logistic regression analysis showed that male sex (odds ratio (OR) = 3.12; 95% confidence interval (CI) = 1.18–8.25,P=0.02), smoking (OR = 3.41, 95% CI = 1.55–7.50,P=0.002), triglyceride (OR = 1.89, 95% CI = 1.10–3.25,P=0.02), high-sensitivity C-reactive protein (OR = 1.24, 95% CI = 1.02–0.03,P=0.03), and suPAR (OR = 1.37, 95% CI = 1.09–1.72,P=0.007) were independently associated with CAD risk in young patients.Conclusions. SuPAR is a novel independent risk factor for CAD in young Chinese patients. Further studies evaluating the effect of anti-inflammatory treatment on the suPAR levels and the risk of CAD are needed.

Sign in / Sign up

Export Citation Format

Share Document