IMPACT OF BARIATRIC SURGERY ON THE INFLAMMATORY STATE BASED ON CPR VALUE

ABSTRACT Background: PCR (C-reactive protein), produced in the liver after stimuli of inflammatory mediators, is determined as a marker of inflammatory activity (adipocytokines) and is present within adipocyte cells; besides being an inflammatory product, many studies have shown to be a predictor of complications. Aim: To determine if the inflammatory state of the obese patient decreases after bariatric surgery, based on pre and post-operative PCR. Methods: A prospective, observational study in patients undergoing Roux-en-Y gastric by-pass surgery followed up for three months after surgery, with serum preoperative CRP in 30, 60 and 90 days after surgery. Results: A total of 19 patients, who had a mean CRP value before the surgical procedure of 0.80(±0.54) mg/dl, were followed, and when compared to the CRP with 30 days of surgery, they presented a significant increase to 2.68 mg/dl (p=0.012). When compared with the PCR of 60 days after the surgical procedure, it was also higher with the value of 3.32 mg/dl (p=0.27). However, at three months after surgery, the CRP showed a decrease when compared to the preoperative mark, with value of 0.45 mg/dl (p=0.0042). Conclusion: Roux-en-Y gastric bypass was able to decrease the chronic inflammation status of these patients, based on the value of CRP, with three months of surgery.

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Plasma levels of soluble urokinase plasminogen activator receptor (suPAR) and high-sensitivity C-reactive protein after Roux-en-Y gastric bypass or sleeve gastrectomy: a 1-year prospective observational study

Journal of Endocrinological Investigation ◽

10.1007/s40618-020-01358-7 ◽

2020 ◽

Author(s):

A. Kokkinos ◽

C. Liaskos ◽

K. Alexiadou ◽

I. Papassotiriou ◽

A. Margeli ◽

...

Keyword(s):

Gastric Bypass ◽

Sleeve Gastrectomy ◽

Observational Study ◽

Plasma Levels ◽

Prospective Observational Study ◽

High Sensitivity ◽

C Reactive Protein ◽

Urokinase Plasminogen Activator Receptor ◽

Reactive Protein ◽

Plasminogen Activator Receptor

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B-type natriuretic peptide and high sensitive C-reactive protein predict 2-year all cause mortality in chest pain patients: a prospective observational study from Salta, Argentina

BMC Cardiovascular Disorders ◽

10.1186/1471-2261-11-57 ◽

2011 ◽

Vol 11 (1) ◽

Cited By ~ 5

Author(s):

Ricardo León de la Fuente ◽

Patrycja A Naesgaard ◽

Stein Tore Nilsen ◽

Leik Woie ◽

Torbjoern Aarsland ◽

...

Keyword(s):

Chest Pain ◽

Observational Study ◽

Natriuretic Peptide ◽

Prospective Observational Study ◽

C Reactive Protein ◽

Reactive Protein ◽

All Cause Mortality ◽

Pain Patients

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C-REACTIVE PROTEIN IN DIABETIC PATIENTS BEFORE GASTRIC BYPASS AS A POSSIBLE MARKER FOR POSTOPERATIVE COMPLICATION

ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) ◽

10.1590/s0102-6720201500s100005 ◽

2015 ◽

Vol 28 (suppl 1) ◽

pp. 11-14 ◽

Cited By ~ 3

Author(s):

Daniel C. LINS ◽

Josemberg M. CAMPOS ◽

Patrícia S. de PAULA ◽

Manoel GALVÃO-NETO ◽

Eduardo PACHU ◽

...

Keyword(s):

Diabetes Mellitus ◽

Type 2 Diabetes ◽

Gastric Bypass ◽

Type 2 Diabetes Mellitus ◽

Postoperative Complications ◽

Statistical Significance ◽

C Reactive Protein ◽

Reactive Protein ◽

Inflammatory State

Background : Obesity and type 2 diabetes mellitus are associated to inflammatory state, which can be set off by the adipose tissue, once it is a metabolically active organ that can cause a chronic mild inflammatory state. Aim : To evaluate the correlation between preoperative C-reactive protein and postoperative complications risk in obese patients (grades II and III) after Roux-en-Y gastric bypass, with and without type 2 diabetes mellitus. Methods : Between 2008 and 2013 were analysed 209 patients (107 with diabetes), presenting body mass index >40 kg/m2or >35 kg/m2with comorbidities. During the postoperative period, two groups were evaluated: with and without complications. Preoperative ultra-sensitive C-reactive protein was measured by immunonephelometry method. Results : Complications occurred in seven patients (pulmonary thromboembolism, fistula, two cases of suture leak, pancreatitis, evisceration and upper digestive hemorrhage). No statistical significance was found regarding lipid profile and C-reactive protein between patients with and without type 2 diabetes mellitus. When compared to each other, both groups (with and without complications) presented with statistical significance regarding C-reactive protein level (7,2 mg/dl vs 3,7 mg/dl, p=0,016) and had similar weight loss percentage after 3, 6 and 12 months follow-up. Conclusions : Preoperative C-reactive protein serum level was higher in the group which presented complications after Roux-en-Y gastric bypass when compared to the group without postoperative complications.

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