scholarly journals Near-Infrared Light-Responsive Nitric Oxide Delivery Platform for Enhanced Radioimmunotherapy

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Xuanfang Zhou ◽  
Zhouqi Meng ◽  
Jialin She ◽  
Yaojia Zhang ◽  
Xuan Yi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Delivery System ◽  
Near Infrared ◽  
Combined Therapy ◽  
Tumor Model ◽  
Immune Checkpoint Blockade ◽  
Infrared Light ◽  
High Dose ◽  
High Concentration ◽  
Therapy Strategy

AbstractRadiotherapy (RT) is a widely used way for cancer treatment. However, the efficiency of RT may come with various challenges such as low specificity, limitation by resistance, high dose and so on. Nitric oxide (NO) is known a very effective radiosensitizer of hypoxic tumor. However, NO cannot circulate in body with high concentration. Herein, an NIR light-responsive NO delivery system is developed for controlled and precisely release of NO to hypoxic tumors during radiotherapy. Tert-Butyl nitrite, which is an efficient NO source, is coupled to Ag2S quantum dots (QDs). NO could be generated and released from the Ag2S QDs effectively under the NIR irradiation due to the thermal effect. In addition, Ag is also a type of heavy metal that can benefit the RT therapy. We demonstrate that Ag2S NO delivery platforms remarkably maximize radiotherapy effects to inhibit tumor growth in CT26 tumor model. Furthermore, immunosuppressive tumor microenvironment is improved by our NO delivery system, significantly enhancing the anti-PD-L1 immune checkpoint blockade therapy. 100% survival rate is achieved by the radio-immune combined therapy strategy based on the Ag2S NO delivery platforms. Our results suggest the promise of Ag2S NO delivery platforms for multifunctional cancer radioimmunotherapy.

Azo-functionalized Fe3O4 nanoparticles: a near-infrared light triggered drug delivery system for combined therapy of cancer with low toxicity

2016 ◽  
Vol 4 (21) ◽  
pp. 3660-3669 ◽  
Author(s):  
Ling Chen ◽  
Lin Wu ◽  
Fei Liu ◽  
Xueyong Qi ◽  
Yanru Ge ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Near Infrared ◽  
Combined Therapy ◽  
Infrared Light ◽  
Nir Light ◽  
Low Toxicity ◽  
Smart Drug ◽  
Smart Drug Delivery

A smart drug delivery system based on thermo-sensitive molecule was designed. When exposed to near infrared (NIR) light, Fe3O4 nanoparticles transfer the light to heat rapidly, leading to the cleavage of the Azo linker and the release of DOX.

scholarly journals Near-Infrared Photoimmunotherapy Using a Small Protein Mimetic for HER2-Overexpressing Breast Cancer

2019 ◽  
Vol 20 (23) ◽  
pp. 5835 ◽  
Author(s):  
Yamaguchi ◽  
Pantarat ◽  
Suzuki ◽  
Evdokiou
Keyword(s):  
Breast Cancer ◽  
Monoclonal Antibody ◽  
Cell Death ◽  
Cancer Cells ◽  
Near Infrared ◽  
Infrared Light ◽  
High Dose ◽  
High Concentration ◽  
Small Protein

Near-infrared photoimmunotherapy (NIR-PIT) is a new and promising cancer therapy based on a monoclonal antibody conjugated to a photosensitizer which is activated by near-infrared light irradiation, causing cell death. We investigated NIR-PIT using a small protein mimetic (6–7 kDa), Affibody molecules, instead of a monoclonal antibody for HER2-overexpressing cancer. Because of its small size, the Affibody has rapid clearance, high imaging contrast, and good tumor penetration. Due to the small size of the Affibodies, which can cross the blood–brain barrier, NIR-PIT using Affibodies has the potential to extend the target cancer of NIR-PIT, including brain metastases. In vitro, NIR-PIT using HER2 Affibody–IR700Dye conjugates induced the selective destruction of HER2-overexpressing breast cancer cells without damage to control cells having low level expression of HER2. HER2-overexpressing cancer cells showed necrotic cell death and their viability maintained at low levels, even 5 days after NIR-PIT. In contrast, treatment with high concentration of HER2 Affibody–IR700Dye conjugate alone or irradiation with high dose of NIR light alone was without effect on cell viability. Affibody and IR700Dye are currently used clinically, and therefore, we would expect the current formulation to be safely and quickly transitioned into clinical trials.

scholarly journals A Multifunctional Biodegradable Prussian blue Analogue for Synergetic Photothermal/Photodynamic/Chemodynamic therapy and Intrinsic Tumor Metastasis Inhibition

2021 ◽  
Author(s):  
Yuting Hao ◽  
Lianzhi Mao ◽  
Rongjun Zhang ◽  
Xiaoshan Liao ◽  
Miaomiao Yuan ◽  
...  
Keyword(s):  
Prussian Blue ◽  
Tumor Metastasis ◽  
Near Infrared ◽  
Combined Therapy ◽  
Infrared Light ◽  
Inhibition Activity ◽  
Tumor Treatment ◽  
Mesenchymal Transition ◽  
Therapy Strategy ◽  
Metastasis Inhibition

Abstract Background To date, various Prussian blue analogues (PBA) have been prepared for biomedical applications due to their unique structural advantages. However, the safety and effectiveness of tumor treatment still need further exploration. Results This contribution reports a facile synthesis of novel PBA with superior tumor synergetic therapy effects and a detailed mechanistic evaluation of their intrinsic tumor metastasis inhibition activity. The as-synthesized PBA have a uniform cube structure with a diameter of approximately 220 nm and showed high near infrared light (NIR) photoreactivity, photothermal conversion efficiency (41.44%) and photodynamic effect. Additionally, PBA could lead to chemodynamic effect which caused by Fenton reaction and ferroptosis. The combined therapy strategy of PBA exhibit notable tumor ablation properties due to photothermal therapy (PTT)/photodynamic therapy (PDT)/ chemodynamic therapy (CDT) effect without obvious toxicity in vivo. The PBA also demonstrate potential as a contrast agent for magnetic resonance imaging (MRI) and photoacoustic (PA) imaging. More importantly, careful investigations reveal that PBA displays excellent biodegradation and anti-metastasis properties. Further exploration of this PBA implies that its underlying mechanism of intrinsic tumor metastasis inhibition activity can be attributed to modulation of epithelial mesenchymal transition (EMT) expression. Conclusions The considerable potential exhibits by as-synthesized PBA make it an ideal candidate as a synergetic therapeutic agent for tumor treatment.

scholarly journals Near-Infrared Light Triggered ROS-activated Theranostic Platform based on Ce6-CPT-UCNPs for Simultaneous Fluorescence Imaging and Chemo-Photodynamic Combined Therapy

Theranostics ◽  
2016 ◽  
Vol 6 (4) ◽  
pp. 456-469 ◽  
Author(s):  
Caixia Yue ◽  
Chunlei Zhang ◽  
Gabriel Alfranca ◽  
Yao Yang ◽  
Xinquan Jiang ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Near Infrared ◽  
Combined Therapy ◽  
Infrared Light ◽  
Near Infrared Light

Dendrimer-modified gold nanorods as efficient controlled gene delivery system under near-infrared light irradiation

2011 ◽  
Vol 152 ◽  
pp. e137-e139 ◽  
Author(s):  
Daxiang Cui ◽  
Peng Huang ◽  
Chunlei Zhang ◽  
Cengiz S. Ozkan ◽  
Bifeng Pan ◽  
...  
Keyword(s):  
Gene Delivery ◽  
Delivery System ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Light Irradiation ◽  
Infrared Light ◽  
Gene Delivery System ◽  
Near Infrared Light

scholarly journals Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer

Nanomaterials ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. 91 ◽  
Author(s):  
Chuan Zhang ◽  
Yuzhuo Wang ◽  
Yue Zhao ◽  
Hou Liu ◽  
Yueqi Zhao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Near Infrared ◽  
Mixed Micelles ◽  
Infrared Light ◽  
Stimuli Responsive ◽  
High Concentration ◽  
Chemotherapy Drugs ◽  
In Vivo Experiments ◽  
Low Efficiency

The chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate). Chemically linking cypate into the mixed micelles greatly improved cypate solubility and PTT/PDT effect. The micelles also exhibited good monodispersity and stability in cell medium (~119.7 nm), low critical micelles concentration, good biodegradation, and photodecomposition. The high concentration of GSH in cancer cells and near-infrared light (NIR)-mediated cypate decomposition were able to achieve DOX centralized release. Meanwhile, the DOX-based chemotherapy combined with cypate-based NIR-triggered hyperthermia and reactive oxygen species could synergistically induce HepG2 cell death and apoptosis. The in vivo experiments confirmed that the micelles generated hyperthermia and achieved a desirable therapeutic effect. Therefore, the designed biodegradable micelles are promising safe nanovehicles for antitumor drug delivery and chemo/PTT/PDT combination therapy.

Near-infrared light-mediated and nitric oxide-supplied nanospheres for enhanced synergistic thermo-chemotherapy

2019 ◽  
Vol 7 (4) ◽  
pp. 548-555 ◽  
Author(s):  
Chuan Zhang ◽  
Qiqing Li ◽  
Yue Zhao ◽  
Hou Liu ◽  
Shanliang Song ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light

Near infrared light/glutathione-responsive nanospheres for expanding nitric oxide application and enhancing synergistic thermal-chemotherapy.

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