Malnutrition, poor function and comorbidities predict mortality up to one year after hip fracture: a cohort study of 2800 patients

2021 ◽  
Author(s):  
Christina Frölich Frandsen ◽  
Eva Natalia Glassou ◽  
Maiken Stilling ◽  
Torben Baek Hansen
Keyword(s):  
Cohort Study ◽  
Hip Fracture ◽  
One Year

scholarly journals Mortality in older adults following a fragility fracture: real-world retrospective matched-cohort study in Ontario

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Jacques P. Brown ◽  
Jonathan D. Adachi ◽  
Emil Schemitsch ◽  
Jean-Eric Tarride ◽  
Vivien Brown ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hip Fracture ◽  
Fragility Fracture ◽  
Mortality Risk ◽  
Real World ◽  
First Year ◽  
Matched Cohort ◽  
Matched Cohort Study ◽  
Fracture Cohort ◽  
One Year

Abstract Background Recent studies are lacking reports on mortality after non-hip fractures in adults aged > 65. Methods This retrospective, matched-cohort study used de-identified health services data from the publicly funded healthcare system in Ontario, Canada, contained in the ICES Data Repository. Patients aged 66 years and older with an index fragility fracture occurring at any osteoporotic site between 2011 and 2015 were identified from acute hospital admissions, emergency and ambulatory care using International Classification of Diseases (ICD)-10 codes and data were analyzed until 2017. Thus, follow-up ranged from 2 years to 6 years. Patients were excluded if they presented with an index fracture occurring at a non-osteoporotic fracture site, their index fracture was associated with a trauma code, or they experienced a previous fracture within 5 years prior to their index fracture. This fracture cohort was matched 1:1 to controls within a non-fracture cohort by date, sex, age, geography and comorbidities. All-cause mortality risk was assessed. Results The survival probability for up to 6 years post-fracture was significantly reduced for the fracture cohort vs matched non-fracture controls (p < 0.0001; n = 101,773 per cohort), with the sharpest decline occurring within the first-year post-fracture. Crude relative risk of mortality (95% confidence interval) within 1-year post-fracture was 2.47 (2.38–2.56) in women and 3.22 (3.06–3.40) in men. In the fracture vs non-fracture cohort, the absolute mortality risk within one year after a fragility fracture occurring at any site was 12.5% vs 5.1% in women and 19.5% vs 6.0% in men. The absolute mortality risk within one year after a fragility fracture occurring at a non-hip vs hip site was 9.4% vs 21.5% in women and 14.4% vs 32.3% in men. Conclusions In this real-world cohort aged > 65 years, a fragility fracture occurring at any site was associated with reduced survival for up to 6 years post-fracture. The greatest reduction in survival occurred within the first-year post-fracture, where mortality risk more than doubled and deaths were observed in 1 in 11 women and 1 in 7 men following a non-hip fracture and in 1 in 5 women and 1 in 3 men following a hip fracture.

Immediate Risk for Cardiovascular Events in Hip Fracture Patients: A Population-Based Cohort Study

2021 ◽  
Author(s):  
Warrington W Q Hsu ◽  
Chor-Wing Sing ◽  
Gloria H Y Li ◽  
Kathryn C B Tan ◽  
Bernard M Y Cheung ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hip Fracture ◽  
Cardiovascular Events ◽  
Population Based ◽  
Competing Risk ◽  
Major Adverse Cardiovascular Events ◽  
Early Management ◽  
Risk Of Death ◽  
One Year ◽  
Subsequent Risk

Abstract Background Emerging evidence showed that bone metabolism and cardiovascular diseases (CVD) are closely related. We previously observed a potential immediate risk of cardiovascular mortality after hip fracture. However, whether there is an immediate risk of cardiovascular events after hip fracture is unclear. The aim of this study was to evaluate the risk for major adverse cardiovascular events (MACEs) between patients having experienced falls with and without hip fracture. Methods This retrospective population-based cohort study used data from a centralized electronic health record database managed by Hong Kong Hospital Authority. Patients having experienced falls with and without hip fracture were matched by propensity score (PS) at a 1:1 ratio. Adjusted associations between hip fracture and risk of MACEs were evaluated using competing risk regression after accounting for competing risk of death. Results Competing risk regression showed that hip fracture was associated with increased one-year risk of MACEs (hazard ratio [HR], 1.27; 95% CI, 1.21 to 1.33; p&lt;0.001), with a 1-year cumulative incidence difference of 2.40% (1.94% to 2.87%). The HR was the highest in the first 90-day after hip fracture (HR of 1.32), and such an estimate was continuously reduced in 180-day, 270-day, and 1-year after hip fracture. Conclusions Hip fracture was associated with increased immediate risk of MACEs. This study suggested that a prompt evaluation of MACE among older adults aged 65 years and older who are diagnosed with hip fracture irrespectively of cardiovascular risk factors may be important, as early management may reduce subsequent risk of MACE.

scholarly journals Mortality incidence and its determinants after fragility hip fractures: a prospective cohort study from an Egyptian level one trauma center

2021 ◽  
Vol 21 (2) ◽  
pp. 806-816
Author(s):  
Mohammad K Abdelnasser ◽  
Ahmed A Khalifa ◽  
Khaled G Amir ◽  
Mohammad A Hassan ◽  
Amr A Eisa ◽  
...  
Keyword(s):  
Cohort Study ◽  
Hip Fracture ◽  
Mortality Rate ◽  
Hospital Mortality ◽  
Hip Fractures ◽  
Prospective Cohort ◽  
Mortality Rates ◽  
Trochanteric Fractures ◽  
Fragility Hip Fracture ◽  
One Year

Background: Fragility hip fracture is a common condition with serious consequences. Most outcomes data come from Western and Asian populations. There are few data from African and Middle Eastern countries. Objective: The primary objective was to describe mortality rates after fragility hip fracture in a Level-1 trauma centre in Egypt. The secondary objective was to study the causes of re-admissions, complications, and mortality. Methods: A prospective cohort study of 301 patients, aged > 65 years, with fragility hip fractures. Data collected included sociodemographic, co-morbidities, timing of admission, and intraoperative,ostoperative, and post-discharge data as mortal- ity, complications, hospital stay, reoperation, and re-admission. Cox regression analysis was conducted to investigate factors associated with 1-year mortality. Results: In-hospital mortality was 8.3% (25 patients) which increased to 52.8% (159 patients) after one year; 58.5% of the deaths occurred in the first 3-months. One-year mortality was independently associated with increasing age, ASA 3-4, cardiac or hepatic co-morbidities, trochanteric fractures, total hospital stay, and postoperative ifection and metal failure. Conclusion: Our in-hospital mortality rate resembles developed countries reports, reflecting good initial geriatric health- care. However, our 3- and 12-months mortality rates are unexpectedly high. The implementation of orthogeriatric care after discharge is mandatory to decrease mortality rates. Keywords: Fragility hip fractures; trochanteric fractures; mortality rate.

scholarly journals EXAMINING DIFFERENCES IN RECOVERY OUTCOMES BETWEEN MALE AND FEMALE HIP FRACTURE PATIENTS: DESIGN AND BASELINE RESULTS OF A PROSPECTIVE COHORT STUDY FROM THE BALTIMORE HIP STUDIES

2018 ◽  
pp. 1-8
Author(s):  
D. ORWIG ◽  
M.C. HOCHBERG ◽  
A.L. GRUBER-BALDINI ◽  
B. RESNICK ◽  
R.R. MILLER ◽  
...  
Keyword(s):  
Sex Differences ◽  
Cohort Study ◽  
Hip Fracture ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Functional Performance ◽  
Cognitive Testing ◽  
Physically Active ◽  
Male And Female ◽  
One Year

Background: Incidence of hip fractures in men is expected to increase, yet little is known about consequences of hip fracture in men compared to women. It is important to investigate differences at time of fracture using the newest technologies and methodology regarding metabolic, physiologic, neuromuscular, functional, and clinical outcomes, with attention to design issues for recruiting frail older adults across numerous settings. Objectives: To determine whether at least moderately-sized sex differences exist across several key outcomes after a hip fracture. Design, Setting, & Participants: This prospective cohort study (Baltimore Hip Studies 7th cohort [BHS-7]) was designed to include equal numbers of male and female hip fracture patients to assess sex differences across various outcomes post-hip fracture. Participants were recruited from eight hospitals in the Baltimore metropolitan area within 15 days of admission and were assessed at baseline, 2, 6 and 12 months post-admission. Measurements: Assessments included questionnaire, functional performance evaluation, cognitive testing, measures of body composition, and phlebotomy. Results: Of 1709 hip fracture patients screened from May 2006 through June 2011, 917 (54%) were eligible and 39% (n=362) provided informed consent. The final analytic sample was 339 (168 men and 171 women). At time of fracture, men were sicker (mean Charlson score= 2.4 vs. 1.6; p<0.001) and had worse cognition (3MS score= 82.3 vs. 86.2; p<0.05), and prior to fracture were less likely to be on bisphosphonates (8% vs. 39%; p<0.001) and less physically active (2426 kilocalories/week vs. 3625; p<0.001). Conclusions: This paper provides the study design and methodology for recruiting and assessing hip fracture patients and evidence of baseline and pre-injury sex differences which may affect eventual recovery one year later.

scholarly journals One-year mortality after hip fracture surgery and prognostic factors: a prospective cohort study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mattia Morri ◽  
Elisa Ambrosi ◽  
Paolo Chiari ◽  
Antonella Orlandi Magli ◽  
Domenica Gazineo ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Cohort Study ◽  
Hip Fracture ◽  
Predictive Factors ◽  
Hip Fractures ◽  
Roc Curve ◽  
Hip Fracture Surgery ◽  
One Year ◽  
Fracture Surgery

AbstractOlder adult patients with hip fractures are 3–4 times more likely to die within one-year after surgery than general population. The study aimed to identify independent predictive factors associated with one-year mortality after hip fracture surgery. A prospective prognostic cohort study was performed. All patients aged ≥65 years, consecutively admitted in three Italian hospitals with a diagnosis of fragility hip fracture were included. Patients with periprosthetic or pathological fractures were excluded. Multivariate analysis was used to determine variables that significantly increased the risk of one-year mortality and Receiver operating characteristic (ROC) curve analysis to assess their predictive capacity on the outcome.1083 patients fulfilled the inclusion criteria and the one-year follow-up was reached in 728 patients. The 16.6% of patients died within one-year after surgery. At the multivariate analysis, advancing age (OR = 1.094, 95% CI = 1.057–1.132), higher baseline Charlson Index (OR = 1.257, 95% CI = 1.114–1.418) and Activities of Daily Living scores (OR = 1.259, 95% CI = 1.143–1.388), presence of hospital-acquired pressure ulcers (PUs) (OR = 1.579, 95% CI = 1.002–2.489) and lack recovery of ambulation (OR = 1.736, 95% CI = 1.115–2.703), were found to be independent predictive factors of one-year mortality after surgery. The area under the ROC curve of the model was 0.780 (CI95% 0.737–0.824) for one-year mortality in elderly hip fractures patients. Early ambulation and careful long-term follow-up, with attention to frailty in elderly people, should be promoted.

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