Recent advances in stimuli-responsive drug release and targeting concepts using mesoporous silica nanoparticles

Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

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Stimuli-responsive functionalized mesoporous silica nanoparticles for drug release in response to various biological stimuli

Biomaterials Science ◽

10.1039/c3bm60148j ◽

2014 ◽

Vol 2 (1) ◽

pp. 121-130 ◽

Cited By ~ 67

Author(s):

Xin Chen ◽

Xiaoyu Cheng ◽

Alexander H. Soeriyadi ◽

Sharon M. Sagnella ◽

Xun Lu ◽

...

Keyword(s):

Drug Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Stimuli Responsive ◽

Functionalized Mesoporous Silica

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A study of chitosan hydrogel with embedded mesoporous silica nanoparticles loaded by ibuprofen as a dual stimuli-responsive drug release system for surface coating of titanium implants

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2014.10.013 ◽

2014 ◽

Vol 123 ◽

pp. 657-663 ◽

Cited By ~ 59

Author(s):

Pengkun Zhao ◽

Hongyu Liu ◽

Hongbing Deng ◽

Ling Xiao ◽

Caiqin Qin ◽

...

Keyword(s):

Drug Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Surface Coating ◽

Mesoporous Silica Nanoparticles ◽

Titanium Implants ◽

Stimuli Responsive ◽

Chitosan Hydrogel ◽

Release System ◽

Drug Release System

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Recent Advances in Application of Azobenzenes Grafted on Mesoporous Silica Nanoparticles in Controlled Drug Delivery Systems Using Light as External Stimulus

Mini-Reviews in Medicinal Chemistry ◽

10.2174/1389557519666190904145355 ◽

2020 ◽

Vol 20 (11) ◽

pp. 1001-1016

Author(s):

Sandra Ramírez-Rave ◽

María Josefa Bernad-Bernad ◽

Jesús Gracia-Mora ◽

Anatoly K. Yatsimirsky

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery Systems ◽

Mesoporous Silica Nanoparticles ◽

High Surface ◽

Delivery Systems ◽

Surface Reactivity ◽

External Stimulus ◽

Recent Advances

Hybrid materials based on Mesoporous Silica Nanoparticles (MSN) have attracted plentiful attention due to the versatility of their chemistry, and the field of Drug Delivery Systems (DDS) is not an exception. MSN present desirable biocompatibility, high surface area values, and a well-studied surface reactivity for tailoring a vast diversity of chemical moieties. Particularly important for DDS applications is the use of external stimuli for drug release. In this context, light is an exceptional alternative due to its high degree of spatiotemporal precision and non-invasive character, and a large number of promising DDS based on photoswitchable properties of azobenzenes have been recently reported. This review covers the recent advances in design of DDS using light as an external stimulus mostly based on literature published within last years with an emphasis on usually overlooked underlying chemistry, photophysical properties, and supramolecular complexation of azobenzenes.

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Current Stimuli-Responsive Mesoporous Silica Nanoparticles for Cancer Therapy

Pharmaceutics ◽

10.3390/pharmaceutics13010071 ◽

2021 ◽

Vol 13 (1) ◽

pp. 71

Author(s):

Thashini Moodley ◽

Moganavelli Singh

Keyword(s):

Cancer Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Therapeutic Agents ◽

Metal Species ◽

Stimuli Responsive ◽

Combination Drug ◽

Incidence And Mortality

With increasing incidence and mortality rates, cancer remains one of the most devastating global non-communicable diseases. Restricted dosages and decreased bioavailability, often results in lower therapeutic outcomes, triggering the development of resistance to conventionally used drug/gene therapeutics. The development of novel therapeutic strategies using multimodal nanotechnology to enhance specificity, increase bioavailability and biostability of therapeutics with favorable outcomes is critical. Gated vectors that respond to endogenous or exogenous stimuli, and promote targeted tumor delivery without prematurely cargo loss are ideal. Mesoporous silica nanoparticles (MSNs) are effective delivery systems for a variety of therapeutic agents in cancer therapy. MSNs possess a rigid framework and large surface area that can incorporate supramolecular constructs and varying metal species that allow for stimuli-responsive controlled release functions. Its high interior loading capacity can incorporate combination drug/gene therapeutic agents, conferring increased bioavailability and biostability of the therapeutic cargo. Significant advances in the engineering of MSNs structural and physiochemical characteristics have since seen the development of nanodevices with promising in vivo potential. In this review, current trends of multimodal MSNs being developed and their use in stimuli-responsive passive and active targeting in cancer therapy will be discussed, focusing on light, redox, pH, and temperature stimuli.

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AuNP and ssDNA capped mesoporous silica nanoparticles for laser controlled drug release

RSC Advances ◽

10.1039/c9ra07404j ◽

2019 ◽

Vol 9 (60) ◽

pp. 34958-34962 ◽

Cited By ~ 1

Author(s):

Lu Zhou ◽

Guojie Liu ◽

Yang Wang ◽

Jianling Liu ◽

Yajie Zhang ◽

...

Keyword(s):

Gold Nanoparticles ◽

Drug Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Controlled Drug Release

Gold nanoparticles were linked to the surface of mesoporous silica through a polyA oligonucleotide and infrared stimulation controlled drug release.

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Mesoporous Silica Nanoparticles: Their Projection in Nanomedicine

ISRN Materials Science ◽

10.5402/2012/608548 ◽

2012 ◽

Vol 2012 ◽

pp. 1-20 ◽

Cited By ~ 26

Author(s):

María Vallet-Regí

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Surrounding Medium ◽

Stimuli Responsive ◽

Guest Molecules ◽

Different Types ◽

Potential Applications ◽

Inorganic Nanomaterials

Mesoporous silica nanoparticles are receiving growing attention by the scientific biomedical community. Among the different types of inorganic nanomaterials, mesoporous silica nanoparticles have emerged as promising multifunctional platforms for nanomedicine. Since their introduction in the drug delivery landscape in 2001, mesoporous materials for drug delivery are receiving growing scientific interest for their potential applications in the biotechnology and nanomedicine fields. The ceramic matrix efficiently protects entrapped guest molecules against enzymatic degradation or denaturation induced by pH and temperature as no swelling or porosity changes take place as a response to variations in the surrounding medium. It is possible to load huge amounts of cargo into the mesopore voids and capping the pore entrances with different nanogates. The application of a stimulus provokes the nanocap removal and triggers the departure of the cargo. This strategy permits the design of stimuli-responsive drug delivery nanodevices.

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