Histiocytoid cardiomyopathy: A cause of sudden death in apparently healthy infants

An ECG was taken on each of 683 apparently healthy children. Flat, inverted or diphasic T or P waves never occurred in Lead I, rarely occurred in Lead II and frequently occurred in Lead III. The QRS interval tends to be shorter in children than in adults and increases with age from 6 months to 9 years. Measurements less than 0.04 sec. or greater than 0.08 sec. are rare in healthy children under the age of 9 years. The PR (PQ) interval tends to be shorter in children than in adults and increases with age from 6 months to 9 years. PR (PQ) intervals of 0.15 sec. or more are rare in healthy children under the age of 4 years. PR (PQ) intervals of 0.16 sec. or more are very rare in healthy children from 4 to 9 years of age.

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Ultrasound Screening of Healthy Infants for Urinary Tract Abnormalities

PEDIATRICS ◽

10.1542/peds.82.4.609 ◽

1988 ◽

Vol 82 (4) ◽

pp. 609-614

Author(s):

Jacob M. Steinhart ◽

Jerald P. Kuhn ◽

Bernard Eisenberg ◽

Russell L. Vaughan ◽

Albert J. Maggioli ◽

...

Keyword(s):

Urinary Tract ◽

Renal Ultrasound ◽

Ultrasound Screening ◽

Urinary Tract Abnormalities ◽

Ultrasound Studies ◽

Healthy Infants ◽

Apparently Healthy

The purpose of the study was to determine the incidence of silent but significant urinary tract abnormalities that might be detected by screening renal ultrasound studies of apparently healthy infants. Of 437 babies studied, six were found to have uropathology severe enough to warrant surgery for an incidence of 1.37% or one of every 73 babies studied.

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Sudden death after exertion in apparently healthy boy.

BMJ ◽

10.1136/bmj.4.5674.30 ◽

1969 ◽

Vol 4 (5674) ◽

pp. 30-31

Author(s):

R C Connor

Keyword(s):

Sudden Death ◽

Apparently Healthy

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Histiocytoid cardiomyopathy and sudden death

Human Pathology ◽

10.1016/s0046-8177(96)90117-3 ◽

1996 ◽

Vol 27 (4) ◽

pp. 420-423 ◽

Cited By ~ 17

Author(s):

Mark A Koponen ◽

Robert J Siegel

Keyword(s):

Sudden Death ◽

Histiocytoid Cardiomyopathy

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Complementary feeding pattern and its impact on growth and development of under 2-years infants in upper Egypt

Egyptian Pediatric Association Gazette ◽

10.1186/s43054-021-00061-3 ◽

2021 ◽

Vol 69 (1) ◽

Author(s):

Osama M. El-Asheer ◽

Manal M. Darwish ◽

Ahmed M. Abdullah ◽

Hanaa A. Mohamad

Keyword(s):

Growth And Development ◽

Chronic Conditions ◽

Complementary Feeding ◽

Cross Sectional Study ◽

Early Age ◽

Cross Sectional ◽

Solid Foods ◽

Healthy Infants ◽

Structured Questionnaire ◽

Apparently Healthy

Abstract Background Exclusive BF till the age of 6 months is rare in developing countries and complimentary feeding (CF) are introduced at an early age which is linked to the development of chronic conditions such as childhood obesity, celiac disease, diabetes, and eczema. The aim of our work is to assess complementary feeding practices of infants under the age of 2 years and to study their impact on their growth and development. This study is a cross-sectional study that was carried out over 3 years between March 2016 and March 2019, included 1000 apparently healthy infants aged less than 2 years old who attended University Children Hospital, Egypt. Practices among mothers including timing and types of foods introduced. Semi-structured questionnaire used for data collection and anthropometric measurements analyzed following the WHO Growth Charts. Results The study found that about 80% of infants were introduced to solid foods before 4 months of age. Also, a large number of infants were given liquids other than breast milk before completing their fourth month of age. Conclusion Despite the better mental development of the infants, there is a considerable gap between WHO Guiding Principles for Complementary Feeding and the practices among mothers of infants aged less than 2 years in Egypt.

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VENTRICULAR TACHYCARDIA

The Professional Medical Journal ◽

10.29309/tpmj/2007.14.04.4804 ◽

2007 ◽

Vol 14 (04) ◽

pp. 556-561

Author(s):

MUHAMMAD SHAH GILANI ◽

Abrar Ahmad Khan ◽

ABDUL SATTAR ◽

Arif Rahim Khan ◽

QAISER MAHMOOD

Keyword(s):

Heart Disease ◽

Sudden Death ◽

Healthy Subjects ◽

Prognostic Significance ◽

Cardiovascular Morbidity ◽

Peak Exercise ◽

Maximal Heart Rate ◽

Coronary Risk Factors ◽

Exercise Induced ◽

Apparently Healthy

Introduction: Frequent or complex patterns of ventricular ectopic activity,whether occurring during routine activity or induced by exercise, are often a marker for serious heart disease and aharbinger of sudden death. The detection of such arrhythmias is thus an important responsibility of the physician.Objective: To find the prevalence, associated characteristics and prognostic significance of exercise induced nonsustainedVT in a representative population. Material and Methods: Setting: Nishtar Hospital, Multan. Sample size:1000 patients. Duration: Two years. Study design: Descriptive, analytical study. Sampling Technique: Convenientprobability sampling done. Results: Ten subjects, 7 men and 3 women, with exercise induced VT were identified,representing 1.1% of those tested; only 1 was young than 65 years. All episodes of VT were asymptomatic and nonsustained.In 9 of 10 subjects, VT developed at or near peak exercise. The longest run of VT was 6 beats; multiple runsof VT were present in 4 subjects. Two subjects had exercise induced ST segment depression, but subsequent exercisethallium scintigraphic results were negative in each. Compared with a group of age and sex matched control subjects,those with asymptomatic, non-sustained VT displayed no difference in exercise duration, maximal heart rate, or theprevalence of coronary risk factors or exercise induced ischemia as measured by electrocardiography and thalliumscintigrahy. Over a mean follow period of 2 years, no subject has developed symptoms of heart disease or experiencedsyncope or sudden death. Thus, exercise induced VT in apparently healthy subjects occurs almost exclusively in theelderly, is limited to short, asymptomatic runs of 3 to 6 beats usually near peak exercise, and does not portendincreased cardiovascular morbidity or mortality rates over a 2 year period of observation. Conclusion: Exerciseinduced VT in apparently healthy subjects occurs almost exclusively in the elderly, is limited to short, asymptomaticruns of 3 to 6 beats usually near peak exercise, and does not show increased cardiovascular morbidity or mortalityrates over a 2 year period of observation.

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Neonatal Sudden Death Due to Histiocytoid Cardiomyopathy

Korean Journal of Legal Medicine ◽

10.7580/kjlm.2021.45.3.99 ◽

2021 ◽

Vol 45 (3) ◽

pp. 99-102

Author(s):

Hongil Ha ◽

Hyun Lyoung Koo

Keyword(s):

Electron Microscopy ◽

Cardiac Arrest ◽

Heart Disease ◽

Sudden Death ◽

Papillary Muscles ◽

Dense Granules ◽

Histiocytoid Cardiomyopathy ◽

Eosinophilic Cytoplasm ◽

Nodular Lesions ◽

In Infants And Children

Histiocytoid cardiomyopathy, an extremely rare heart disease in infants and children, usually occurring in girls under the age of 2 years, is characterized by cardiomegaly, ventricular arrhythmia, and sudden death. In the present study, we report a case of a 2-day-old female neonate who suddenly showed cyanosis and cardiac arrest in the neonatal unit and died without resuscitation. Autopsy revealed multifocal nodular lesions in the left ventricle wall and papillary muscles. Microscopically, these lesions were composed of discohesive round or polygonal cells with eosinophilic cytoplasm and were positive for desmin and negative for CD68. Electron microscopy findings displayed abnormal swollen mitochondria with disorganized cristae, dense granules, and diminished myofibrils in the periphery of the cytoplasm.

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