Regulation of insulin binding and stimulation of sugar transport in cultured human fibroblasts by sugar levels in the culture medium

1984 ◽  
Vol 234 (2) ◽  
pp. 559-566 ◽  
Author(s):  
Ralph J. Germinario ◽  
Shiro Ozaki ◽  
Norman Kalant
Keyword(s):  
Culture Medium ◽  
Human Fibroblasts ◽  
Sugar Transport ◽  
Insulin Binding ◽  
Cultured Human Fibroblasts ◽  
Sugar Levels ◽  
Stimulation Of

Stimulation of fetal thymidine kinase in cultured human fibroblasts transformed by SV40 virus

Virology ◽  
1974 ◽  
Vol 57 (1) ◽  
pp. 279-284 ◽  
Author(s):  
David L. Bull ◽  
Andrew T. Taylor ◽  
Donna M. Austin ◽  
Oliver W. Jones
Keyword(s):  
Thymidine Kinase ◽  
Human Fibroblasts ◽  
Sv40 Virus ◽  
Cultured Human Fibroblasts ◽  
Stimulation Of

Exercise increases susceptibility of muscle glucose transport to activation by various stimuli

1990 ◽  
Vol 258 (2) ◽  
pp. E390-E393 ◽  
Author(s):  
G. D. Cartee ◽  
J. O. Holloszy
Keyword(s):  
Insulin Sensitivity ◽  
Glucose Transport ◽  
Sugar Transport ◽  
Insulin Binding ◽  
Insulin Mimetic ◽  
Increased Sensitivity ◽  
Muscle Glucose Transport ◽  
Glucose Analogue ◽  
Stimulation Of

The insulin sensitivity of glucose transport in skeletal muscle is enhanced after exercise. In this study, stimulation of transport of the nonmetabolizable glucose analogue 3-O-methylglucose by the insulin-mimetic agents vanadate and H2O2 was markedly enhanced in rat epitrochlearis muscles 18 h after a bout of swimming. This increase in susceptibility of the glucose transport process in muscle to stimulation by insulin-mimetic agents that act beyond the insulin-binding step provides evidence that the increased insulin sensitivity results from an effect of exercise on a later step in the activation of glucose transport. Hypoxia and insulin appear to stimulate glucose transport by different pathways in muscle as evidenced by an additivity of their maximal effects. The effect of a submaximal hypoxic stimulus on muscle sugar transport was greatly amplified 3 h after exercise. This increase in susceptibility of glucose transport to stimulation by hypoxia after exercise suggests that the increased sensitivity is not limited to the insulin sensitive pathway. In contrast to exercise (i.e., swimming), in vitro muscle contractions did not result in an increase in sensitivity of muscle glucose transport to insulin, raising the possibility that a humoral factor is necessary for this effect.

Effect of pH and 3-Hydroxybutyrate on Insulin Binding and Action in Cultured Human Fibroblasts

Diabetes ◽  
1981 ◽  
Vol 30 (5) ◽  
pp. 402-406 ◽  
Author(s):  
H. Hidaka ◽  
B. V. Howard ◽  
F. Ishibashi ◽  
F. C. Kosmakos ◽  
J. W. Craig ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Insulin Binding ◽  
Effect Of Ph ◽  
Cultured Human Fibroblasts

Effect of pH and 3-hydroxybutyrate on insulin binding and action in cultured human fibroblasts

Diabetes ◽  
1981 ◽  
Vol 30 (5) ◽  
pp. 402-406 ◽  
Author(s):  
H. Hidaka ◽  
B. V. Howard ◽  
F. Ishibashi ◽  
F. C. Kosmakos ◽  
J. W. Craig ◽  
...  
Keyword(s):  
Human Fibroblasts ◽  
Insulin Binding ◽  
Effect Of Ph ◽  
Cultured Human Fibroblasts

Effect of temperature on insulin binding and action in cultured human fibroblasts

Life Sciences ◽  
1983 ◽  
Vol 33 (12) ◽  
pp. 1157-1165 ◽  
Author(s):  
Hideki Hidaka ◽  
Fukashi Ishibashi ◽  
Joseph Larner ◽  
Barbara V. Howard
Keyword(s):  
Human Fibroblasts ◽  
Insulin Binding ◽  
Effect Of Temperature ◽  
Cultured Human Fibroblasts
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