Creatine phosphokinase isozymes of human heart muscle and skeletal muscle

1972 ◽  
Vol 38 (2) ◽  
pp. 285-290 ◽  
Author(s):  
Keiichi Takahashi ◽  
Shigeki Ushikubo ◽  
Munetada Oimomi ◽  
Takeshi Shinko
Keyword(s):  
Skeletal Muscle ◽  
Heart Muscle ◽  
Human Heart ◽  
Creatine Phosphokinase

Effect of vitamin E deficiency on creatine phosphokinase of heart and skeletal muscle

1959 ◽  
Vol 196 (6) ◽  
pp. 1286-1288 ◽  
Author(s):  
W. O. Read ◽  
Said Nehorayan
Keyword(s):  
Skeletal Muscle ◽  
Vitamin E ◽  
Enzymatic Activity ◽  
Heart Muscle ◽  
Creatine Phosphokinase ◽  
Normal Male ◽  
Vitamin E Deficiency ◽  
Severe Vitamin ◽  
Made In

A quantitative determination of creatine phosphokinase activity of heart and skeletal muscle has been made in early and severe vitamin E deficiency in the rabbit. This study revealed that early vitamin E deficiency resulted in an increase in creatine phosphokinase activity of skeletal muscle but decreased the enzymatic activity of the heart. Severe vitamin E deficiency resulted in a decrease in creatine phosphokinase activity of both skeletal and heart muscle. 17-Hydroxycorticosterone, in small doses, resulted in an increase in enzymatic activity of skeletal muscle but no change in heart muscle. Large doses of 17-hydroxycorticosterone caused a decrease in the creatine phosphokinase activity of both heart and skeletal muscle. Normal male rabbits exhibited a lower enzymatic activity than female animals, a difference which, in part, was due to testosterone.

scholarly journals Comparison of slow inactivation in human heart and rat skeletal muscle Na+channel chimaeras

1999 ◽  
Vol 515 (1) ◽  
pp. 61-73 ◽  
Author(s):  
John P. O'Reilly ◽  
Sho-Ya Wang ◽  
Roland G. Kallen ◽  
Ging Kuo Wang
Keyword(s):  
Skeletal Muscle ◽  
Human Heart ◽  
Na Channel ◽  
Slow Inactivation ◽  
Rat Skeletal Muscle

Calculation of the parameters of mechanical properties of the heart muscle

2020 ◽  
Vol 12 ◽  
pp. 42-52
Author(s):  
S. A. Muslov ◽  
◽  
A. I. Lotkov ◽  
S. D. Arutyunov ◽  
T. M. Albakova ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Young’S Modulus ◽  
Elastic Constants ◽  
Heart Muscle ◽  
Human Heart ◽  
Young's Modulus ◽  
Experimental Values ◽  
Two Parameter

A review of studies of the mechanical properties of human and animal heart tissues has been performed. Based on literature data, a form of approximating function is found for the dependence of the Young’s modulus of the ventricles of the human heart on the magnitude of the deformation. The average values of the Young’s modulus and other elastic constants were calculated and compared with the known experimental values. The coefficients C1 and C2 of the two-parameter hyperelastic myocardial Mooney-Rivlin model are calculated.

Patient Case Report Daptomycin Holiday—A Daptomycin Dosing Strategy for Asymptomatic Increases in Creatine Phosphokinase Levels

2020 ◽  
pp. 089719002095823 ◽  
Author(s):  
Leroy Koh ◽  
Punit J. Shah ◽  
Sarfraz Aly
Keyword(s):  
Skeletal Muscle ◽  
Muscle Injury ◽  
Creatine Phosphokinase ◽  
Asymptomatic Patient ◽  
Multidrug Resistant ◽  
Excellent Activity ◽  
Associated Symptoms ◽  
Potential Strategy ◽  
Dosing Strategy

Daptomycin possesses excellent activity against many multidrug-resistant gram positive organisms. However, a side effect of concern with daptomycin is skeletal muscle injury, which is manifested in the form of elevated creatine phosphokinase (CPK). Management of such CPK elevations has traditionally been discontinuation of the offending agent, with many studies showing a resolution of a normal CPK level within 1 week of discontinuation and no long term adverse effects. Nevertheless, the question remains if daptomycin can be successfully restarted in such patients. Here, we present a case of a “daptomycin holiday” in which daptomycin was withheld upon CPK elevation and successfully reintroduced to the patient’s regimen again after several days without further elevation of the CPK. The patient had a peak CPK of 2,557 U/L, and had no associated symptoms. A hypothesis for this holiday could be the adaptability of the skeletal muscle myocytes, in which the extra period between doses may allow for additional recovery of the membrane structure to further daptomycin exposure. Giving an asymptomatic patient with elevated CPK level, a short daptomycin holiday to allow for the CPK level to trend downward before resuming daptomycin therapy could be a potential strategy in patients for whom continuing daptomycin is still preferred.

Complete Heart-block, with Dissociation of the Action of the Auricles and Ventricles

1906 ◽  
Vol 25 (2) ◽  
pp. 1085-1091 ◽  
Author(s):  
W. T. Ritchie
Keyword(s):  
Heart Muscle ◽  
Heart Block ◽  
Human Heart ◽  
Complete Heart Block ◽  
Ventricular Muscle ◽  
Ventricular Systole

The ventricular rhythm differs from the auricular, firstly, on the occurrence of a ventricular extra-systole, and, secondly, in cases where there is allorhythmia due to depression of conductivity of the heart muscle. When conductivity is depressed, the contraction stimulus at regular or irregular intervals may be blocked at the auriculo-ventricular muscle bridge; so that whereas some stimuli induce both auricular and ventricular systole, others induce auricular systole alone, the ventricular systole being missed. That condition, incomplete heart-block, is of not infrequent occurrence in the human heart, and has been graphically recorded by Mackenzie (1), Finkelnburg (2), and other writers.

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