Serum calcium status in health and disease: A comparison of measured and derived parameters

1986 ◽  
Vol 157 (2) ◽  
pp. 199-213 ◽  
Author(s):  
Trevor F. White ◽  
John R. Farndon ◽  
Sergio C. Conceicao ◽  
Michael F. Laker ◽  
Michael K. Ward ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Health And Disease ◽  
Calcium Status

scholarly journals Serum Magnesium and Calcium Status among Term Asphyxiated Newborns with Moderate to Severe Hypoxic-ischemic Encephalopathy (HIE)

2018 ◽  
Vol 26 (2) ◽  
pp. 148-152
Author(s):  
Rifat Zaman ◽  
Md Abid Hossain Mollah ◽  
Mohammad Mahfuzur Rahman Chowdhury ◽  
Shamima Yeasmin ◽  
Abu Sayeed Chowdhury ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Apgar Score ◽  
Calcium Level ◽  
Perinatal Asphyxia ◽  
Pearson Correlation ◽  
Statistical Significance ◽  
Serum Magnesium ◽  
The Body ◽  
Medical College ◽  
Calcium Status

Background & objective: Perinatal asphyxia affects all organs of the body and brain is the most affected organ. The study was undertaken to find out the status of serum magnesium and calcium level and their significant association among asphyxiated term newborns with moderate to severe HIE.Material & methods: The Cross sectional study was done in the Department of Neonatology, Dhaka Medical College Hospital during January 2012 to July 2012. A total of 102 asphyxiated term neonates were enrolled , who has H/O perinatal asphyxia and had Apgar score of 6 or <6 at 5 minutes. Clinical grading of HIE into moderate and severe was done according to modified Sarnat and Sarnat scoring system .Under aseptic precautions with standard protocol , estimation of serum magnesium and calcium level in venous blood was done at 48 hours and 7th day of birth . Among the study population , 17 patients had died during follow up and 4 patients were absconded. Finally 81 patients were evaluated by both blood samples though initial 102 cases were evaluated by their first sample. 50 normal healthy infants were also evaluated for serum magnesium and calcium at their 48 hours of birth. Chi-square test was used to assess statistical significance, Pearson correlation coefficient test was done to find out correlation between serum magnesium and calcium status and APGAR score & t test was done to assess the comparison between the values of serum magnesium and calcium found on two occasions.Results: Of 102 cases majority (58%) were male. Most of the cases (65.68%) were moderate HIE. Mean serum magnesium was 1.36(0.9-2.8) mg/dl and 1.16(.88-2.6) mg/dl among HIE II and HIE III respectively (p<0.05). Mean serum calcium of HIE II and HIE III were 7.14(5.1-9.6) mg/dl and 6.58(5.3-9.0) mg/dl respectively (p<0.05). There is positive correlation with individual APGAR score with serum magnesium (r=0.229, p=0.02) and serum calcium (r=0.231, p=0.019) level. Hypocalcaemia was found 35.82% and 57.14% among HIE II And HIE III cases respectively(p<0.01). Hypomagnesaemia was found 28.36% and 45.71% among HIE II and HIE III (p<0.05).Conclusion: Hypomagnesaemia and hypocalcaemia are significantly associated with the degree of severity of HIE.J Dhaka Medical College, Vol. 26, No.2, October, 2017, Page 148-152

Observations on the calcium intake and serum calcium status of grazing ewes during drought

1967 ◽  
Vol 7 (27) ◽  
pp. 325 ◽  
Author(s):  
JP Langlands ◽  
JM George ◽  
JJ Lynch
Keyword(s):  
Serum Calcium ◽  
Calcium Intake ◽  
Clinical Signs ◽  
Calcium Content ◽  
Calcium Deficiency ◽  
Daily Calcium Intake ◽  
Stocking Rates ◽  
Calcium Status ◽  
Very High ◽  
Improved Pasture

The calcium intakes of two flocks of dry Merino ewes grazing a Phalaris tuberosa-white clover pasture stocked at 3 and 15 sheep per acre and a third flock grazing a native pasture stocked at 1.5 sheep per acre, were estimated from December 1964 to July 1965. The calcium content of the diet was highest on the improved pasture stocked at 15 sheep per acre and ranged from 0.84 to 1.67 per cent of the organic matter. The corresponding range for the other flocks was from 0.24 to 0.96 per cent calcium. Calcium intakes were highest on the heavily stocked pastures. Daily calcium intake on all pastures ranged from 2.8 to 13.5 g. Serum calcium values of 170 sheep stocked at varying rates on different pastures and receiving varying amounts of wheat were determined after 21 months of drought. Nine sheep had serum calcium values less than 8.0 mg per 100 ml serum, but no clinical signs of calcium deficiency were observed. It was concluded that sheep would not be deficient in calcium while they had access to paddock roughage but that hypocalcaemia would occur in sheep run at very high stocking rates and supplemented with wheat without limestone for prolonged periods.

scholarly journals Serum Calcium Status of Neonates with Seizure in a Tertiary Care Hospital

2013 ◽  
Vol 36 (3) ◽  
pp. 122-125 ◽  
Author(s):  
Olia Sharmeen Baten ◽  
Md Abid Hossain Mollah ◽  
Mohammad Nawsher Ali ◽  
Mohammod Hasanur Rashid
Keyword(s):  
Serum Calcium ◽  
Calcium Level ◽  
Tertiary Care ◽  
Specific Treatment ◽  
Neonatal Seizure ◽  
Complex Method ◽  
Care Hospital ◽  
Metabolic Abnormalities ◽  
Metabolic Derangement ◽  
Calcium Status

Background: Seizure is a common neurological disorder in neonatal age group. Primary metabolic derangement is one of the common reason behind this convulsion during this period. Among metabolic abnormalities, hypocalcaemia is most common followed by hypoglycemia and hypomagnesaemia. Objectives: The present study was carried out to assess calcium status in the serum of neonates with convulsion, where no obvious cause of convulsion was found. Methodology: This prospective case control study was conducted in the neonatal ward of Dhaka Medical College Hospital over one year from July 2003 to June 2004. A total of 50 neonates (1- 28 days) who had convulsion but no apparent reasons of convulsion had been found out, were enrolled as cases and 50 age, sex body weight matched neonates who had no history camalnia admitted cases of were enrolled as controls. After a quick clinical evaluation and control of convulsion and before giving any specific treatment serum calcium status was measured by colormetric determination (O- CRE-SOL Phahalein complex) method. Neonatal hypocalcemia is considered if serum calcium value less than1.75 mmol/L (7 mg/dl). Results: Among a total of fifty cases, 60% had hypocalcemia, and about 20% of controls also had low calcium level without any manifestation. The mean serum calcium level of cases and controls were 1.62 ± 0.29 and 2.07 ± 0.03 mmol/l respectively (p<0.001). Conclusion: It is seen that hypocalcemia is an important cause of neonatal seizure due to primary metabolic abnormalities. So early recognition and treatment could save these babies from long term neurological sequelies. DOI: http://dx.doi.org/10.3329/bjch.v36i3.14274 BANGLADESH J CHILD HEALTH 2012; VOL 36 (3) : 122-125

scholarly journals Total Serum Calcium and Recovery after Rehabilitation in Patients with Stroke

2020 ◽  
Vol 10 (21) ◽  
pp. 7893
Author(s):  
Mariacristina Siotto ◽  
Marco Germanotta ◽  
Massimo Santoro ◽  
Chiara Di Blasi ◽  
Claudia Loreti ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Total Protein ◽  
Barthel Index ◽  
Reference Range ◽  
Total Calcium ◽  
Stroke Patients ◽  
Rehabilitation Treatment ◽  
Protein Status ◽  
Subacute Stroke ◽  
Calcium Status

Calcium deficiency is frequently observed in stroke survivors, but no data exist concerning the relationship between calcium and rehabilitation outcome in patients with stroke. Therefore, we examined in a group of subacute stroke patients if changes in the Barthel Index after a rehabilitation treatment were associated with blood parameters related to calcium status. We retrospectively explored serum calcium status (total calcium, ionized calcium), serum total protein status, and serum albumin percentage in 30 subacute stroke patients admitted to our rehabilitation center. Patients underwent a 6-week rehabilitation treatment (each session lasting 45 min, 2 sessions/day, 6 days/week). Overall, 26.7% of patients had total calcium levels below the reference range, whereas 100% of patients had ionized calcium in the reference range. Total protein and albumin were below the reference range in about 77% and 67% of patients, respectively. We found that only total calcium was correlated with the change from baseline of the Barthel Index (BI) (rho = 0.466, p = 0.009). A multiple linear regression model confirmed that in our sample the total calcium significantly predicted the change from baseline of the Barthel Index (F5, 24 = 4.074, p = 0.008, adj. R2 = 0.346). This study suggests a possible connection between serum calcium status and total protein status of stroke patients undergoing rehabilitation treatment and rehabilitation outcomes. Further investigations are necessary to confirm the importance of testing serum calcium status of patients at admission in a rehabilitation unit for an eventual supplementation or a dietary personalized program.

Serum Calcium Status: Correction, Calculation or Measurement?

1985 ◽  
Vol 69 (s12) ◽  
pp. 18P-18P
Author(s):  
TF White ◽  
JR Farndon ◽  
SC Conceicao ◽  
MF Laker ◽  
MK Ward ◽  
...  
Keyword(s):  
Serum Calcium ◽  
Calcium Status ◽  
Correction Calculation

scholarly journals Predictive Value of Derived Calcium Figures Based on the Measurement of Ionised Calcium

1981 ◽  
Vol 18 (2) ◽  
pp. 106-109 ◽  
Author(s):  
Mary D Gardner ◽  
Frances J Dryburgh ◽  
J A Fyffe ◽  
A S Jenkins
Keyword(s):  
Serum Calcium ◽  
Predictive Value ◽  
Calcium Concentration ◽  
Clinical Usefulness ◽  
Total Serum ◽  
Predictive Values ◽  
Serum Calcium Concentration ◽  
Total Serum Calcium ◽  
Ionised Calcium ◽  
Calcium Status

The algorithms used in this hospital to assess calcium status are calculated ionised serum calcium and the serum calcium concentration adjusted for albumin. In order to establish their clinical usefulness, they were compared with the ionised calcium concentration measured on the Nova 2 instrument in patients with various calcium and protein abnormalities. Good correlation was found between the measured and calculated values. The predictive values for the calculated results and for total serum calcium concentrations are presented. In this series, the derived values were useful in predicting the serum ionised calcium concentration of the patients studied.

scholarly journals SUN-LB67 Revisit Serum Calcium Correction

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Yulong Li ◽  
JunJia Zhu ◽  
Jenny Blau ◽  
William F Simonds
Keyword(s):  
Serum Calcium ◽  
Repeated Measures ◽  
Calcium Level ◽  
Ionized Calcium ◽  
Total Serum ◽  
P Value ◽  
Total Calcium ◽  
Total Serum Calcium ◽  
Parathyroid Disease ◽  
Calcium Status

Abstract Context: The serum calcium level is one of most routinely ordered tests in clinical practice. Many factors can affect calcium level and its interpretation. There are challenges and barriers in applying calcium correction formulas to every-day practice. Objective: Revisit correlation between total and ionized calcium levels, and dependence of serum calcium on albumin, pH and creatinine levels. Methods: This study included 1537 subjects enrolled in a parathyroid disease clinical protocol. We examined calcium and relevant biochemistry tests collected simultaneously and repetitively over consecutive years. Histograms, repeated measures correlation, correlation plots, and liner regression plots were used to analyze and visualize the data. Results: We found that: 1) directly measured total serum calcium and ionized calcium had excellent correlation and dependence with p-value=2.2e-16, repeated measures correlation coefficient (rmcorr)=0.919, and 95% interval (CI) = 0.916 to 0.922; 2) there was a low dependence between total serum calcium and albumin levels (rmcorr=0.454, 95% CI=0.433 to 0.474), a low dependence between ionized calcium and pH levels (rmcorr=-0.309, 95% CI= -0.326 to -0.292), and no dependence between total calcium and creatinine levels (rmcorr=0.026 95% CI=0.012 to 0.040); 3) using the commonly applied correction formulas, to either adjust total calcium based on albumin levels or else adjust ionized calcium based on pH levels, did not improve dependence among them. Conclusions: We therefore suggest using directly measured total serum calcium and/or ionized calcium level to assess clinical calcium status in general patients tested for parathyroid related disorders.

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