Thought disorders in schizophrenia before and after pharmacological treatment

1975 ◽  
Vol 16 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Irena Namyslowska
1981 ◽  
Vol 9 (3) ◽  
pp. 211-214 ◽  
Author(s):  
Stefano Passero ◽  
Marcello Nardini ◽  
Noé Battistini

The effect of pentoxifylline on cerebral blood flow (CBF) was studied with the intravenous 133Xe clearance technique in eleven patients with chronic cerebrovascular disease. Pentoxifylline was administered orally at a dose of 1200 mg/day over a period of 30 days (eight patients) or by intravenous infusion of 100 ml saline containing 400 mg of the drug in 1 hour (three patients). CBF was measured before and after pharmacological treatment. CBF was found to be significantly increased by both acute and chronic administration of pentoxifylline.


2009 ◽  
Vol 16 (6) ◽  
pp. 678-683 ◽  
Author(s):  
C. H. Nolte ◽  
G. J. Jungehulsing ◽  
K. Rossnagel ◽  
S. Roll ◽  
K. G. Haeusler ◽  
...  

2021 ◽  
Vol 1 ◽  
pp. 1472-1476
Author(s):  
Fatturichza Yamiendinar ◽  
I Isytiaroh ◽  
Windha Widyastuti

AbstractContraction during labour can be painful. The pain due to labour process can be reduced by performing non-pharmacological treatment of Effleurage. Effelurage is a serries of massage which is done in the abdominal area aiming to reduce pain that arises during the labour process. The purpose of this study was to find out whether Effleurage could reduce pain response of mothers in the first phase labour. The study was a literature review of three articles taken from Google Scholar with the keyword “Effleurage”, “labour pain” and “first phase” in the form of fulltext articles, published in 2019. The respondents of the thre articles 63 mothers who gave birth. The average value of pain response showed by the respondents before and after being treated with Effleurage decreased from 5.883 to 3.576. Therefore, it was concluded that effleurage could be given to mothers to reduce the pain response in the labour process. Moreover, health providers are expected to treat mothers with Effleurage to reduce their pain to the labour process.Keywords: First phase, labour pain, Massage effleurage AbstrakKontraksi selama persalinan dapat menimbulkan rasa nyeri. Rasa nyeri yang dirasakan pada proses persalinan tersebut dapat dikurangi dengan melakukan tindakan non-farmakologis salah satunya berupa pemberianmassage effleurage. Massage effleurage yang dilakukan di area perut untuk membantu mengurangi rasa nyeri yang muncul pada proses persalinan. Tujuan karya tulis ilmiah ini untuk mengetahui apakah massage effleurage dapat menurunkan respon nyeri pada ibu bersalin kala I berdasarkan literatur review. Desain karya tulis ilmiah berupa literatur review dengan jumlah artikel tiga yang diambil dari laman jurnal google scholar dengan kata kunci “massage effleurage”. “nyeri persalinan” dan “kala I” berupa artikel fulltext, terbit tahun 2019. Jumlah responden dari tiga artikel tersebut adalah 63 ibu bersalin. Nilai rata-rata respon nyeri sebelum dilakukan massage effleurage 5,883, dan nilai rata-rata respon nyeri setelah dilakukan massage effleurage 3,576. Simpulannya adalah tindakan massage effleurage dapat membantu menurunkan respon nyeri pada proses persalinan. Saran bagi pelayanan kesehatan agar dapat menerapkan teknik massage effleurage untuk mengurangi nyeri pada proses persalinan.Kata kunci: Massage effleurage,nyeri persalinan, kala I


2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Tomasz Rechberger ◽  
Andrzej Wrobel ◽  
Alicja Zietek ◽  
Ewa Rechberger ◽  
Beata Kulik-Rechberger ◽  
...  

Aim. Lower urinary tract symptoms (LUTS) frequently affect patients immediately after midurethral sling (MUS) placement. The objective of the study was to assess if solifenacin or mirabegron decreases incidence of LUTS in women who underwent transobturator MUS. Methods. A prospective randomized trial was conducted on patients undergoing ambulatory transobturator midurethral sling due to stress urinary incontinence (SUI). All participants were questioned before and after surgery for occurrence of bothersome LUTS. A total of 328 patients who underwent transobturator MUS were randomly assigned to one of three groups: prophylaxis with 10 mg of solifenacin, prophylaxis with 50 mg of mirabegron, or without any additional treatment. LUTS evolution and efficacy of solifenacin and mirabegron were analyzed based on results of assessments made during follow-up visits at 1 and 6 weeks after surgery. Comparison of the prevalence of LUTS was done using chi2 test. Results. Prevalence of urgency and frequency episodes increased notably 1 week after sling placement and then came down to baseline levels. Solifenacin and mirabegron significantly reduced the incidence of urgency after 1 week, but after 6 weeks the beneficial effect was observed only in case of solifenacin. Treatment with mirabegron reduced the percentage of patients suffering from frequency after 6 weeks. Although prevalence of nocturia did not raise after sling placement, both treatments significantly reduced the incidence of this complaint after 6 weeks. Pharmacological treatment did not modulate the course of hesitancy and terminal dribbling. Conclusions. Treatment with solifenacin or mirabegron may significantly reduce the incidence of undesired LUTS after MUS.


2011 ◽  
Vol 187 (3) ◽  
pp. 382-386 ◽  
Author(s):  
Carlo Marchesi ◽  
Paola Parenti ◽  
Sonia Aprile ◽  
Chiara Cabrino ◽  
Chiara De Panfilis

2015 ◽  
Vol 15 (12) ◽  
pp. 587
Author(s):  
Alexandra Coros ◽  
Philippe Chouinard ◽  
Stan Van Uum ◽  
Donald Lee ◽  
Alexander Fraser ◽  
...  

2014 ◽  
Vol 6 (3) ◽  
Author(s):  
Inge Jiemesha ◽  
Engeline Angliadi

Abstract: Osteoarthritis (OA) of the knee is a chronic degenerative joint disease which causes disability affecting the quality of life. Its management may include pharmacological and non-pharmacological treatment. In the non-pharmacological treatment there are a variety of treatment options. This study aimed to prove the effect of Transcutaneous Electrical Nerves Stimulation (TENS) with and without exercise on pain and physical performance in patients with knee OA. There were thirty five patients with knee OA who met the inclusion criteria that visited the Medical Rehabilitation Department of Prof. Dr. R.D. Kandou Hospital. The samples were divided into 2 groups: TENS with exercise therapy and TENS without exercise therapy. Each group undergone their therapy for 6 weeks with a frequency of 2 times per week. Pain was measured by using the Numeric Rating Scale (NRS) and physical performance was measured by using the Timed-Up and Go test (TUG) and the Stair Climb Test (SCT). There were 91.4% females meanwhile overweight and obese patients were 34.3%. The results showed that there were significant differences in pain and physical performance between before and after TENS with exercise (P <0.001) as well as before and after TENS without exercise (P < 0.001). There was no difference in pain and physical performance between the two groups. Conclusion: TENS with and without exercise can reduce pain and improve physical performance in patients with knee osteoarthritis.Keywords: knee osteoarhtritis, TENS, pain, physical performanceAbstrak: Osteoartritis (OA) lutut adalah penyakit degeneratif sendi yang bersifat kronis dan menyebabkan disabilitas yang memengaruhi kualitas hidup penderita. Tatalaksana OA lutut terdiri dari farmakologi dan non-farmakologi dengan bermacam-macam pilihan terapi. Penelitian ini bertujuan untuk membuktikan pengaruh Transcutaneous Electrical Nerves Stimulation (TENS) dengan dan tanpa terapi latihan terhadap nyeri dan kinerja fisik pada penderita OA lutut. Sebanyak 35 penderita OA lutut lama maupun baru yang memenuhi kriteria inklusi, yang berkunjung ke Poliklinik Rehabilitasi Medik RSUP Prof Dr. R.D. Kandou dan bersedia mengikuti penelitian. Sampel dibagi menjadi 2 kelompok: diberikan TENS dengan terapi latihan dan yang tanpa terapi latihan selama 6 minggu dengan frekuensi 2 kali per minggu. Nyeri diukur dengan Numeric Rating Scale (NRS) dan kinerja fisik diukur dengan Timed-Up and Go test (TUG) dan Stair Climb Test (SCT). Dari hasil analisis 35 subyek penelitian didapatkan 32 orang (91,4%) subyek wanita, serta indeks massa tubuh yang overweight dan obese sebanyak 34,3 %. Hasil uji perbedaan nyeri dan kinerja fisik sebelum dan sesudah TENS dengan terapi latihan memperlihatkan perbedaan bermakna (P <0,001). Hasil perbedaan nyeri dan kinerja fisik sebelum dan sesudah TENS juga memperlihatkan perbedaan bermakna (P <0,001). Pada hasil uji perbedaan nyeri dan kinerja fisik pada kedua kelompok didapatkan tidak terdapat perbedaan antara keduanya. Simpulan: TENS dengan dan tanpa terapi latihan dapat mengurangi nyeri dan meningkatkan kinerja fisik pada penderita osteoartritis lutut.Kata kunci: osteoartritis lutut, TENS, nyeri, kinerja fisik


2021 ◽  
Author(s):  
Marie Camerota ◽  
Jonathan M Davis ◽  
Lynne M. Dansereau ◽  
Erica L Oliveira ◽  
James F Padbury ◽  
...  

Objective: To determine whether pharmacological treatment for neonatal abstinence syndrome (NAS) is associated with changes in DNA methylation (DNAm) of the mu-opioid receptor gene (OPRM1) and improvements in neonatal neurobehavior.Study Design: Buccal swabs were collected from 37 neonates before and after morphine treatment for NAS. Genomic DNA was extracted and DNAm was examined at four CpG sites within the OPRM1 gene. The NICU Network Neurobehavioral Scales (NNNS) was also performed before and after NAS treatment. Changes in DNAm (DNAmpost-tx – DNAmpre-tx) and NNNS summary scores (NNNSpost-tx – NNNSpre-tx) were then calculated. Path analysis was used to examine associations among pharmacologic treatment (length of treatment and total dose of morphine), changes in DNAm, and changes in NNNS summary scores. Results: DNAm significantly decreased from pre- to post-treatment at 1 of 4 CpG sites within the OPRM1 gene. Neonates also demonstrated decreased excitability, hypertonia, lethargy, signs of stress and abstinence, and increased quality of movement and regulation from pre- to post-treatment. Increased length of treatment and higher morphine doses were associated with greater decreases in DNAm; greater decreases in DNAm were associated with greater decreases in excitability and hypertonia on the NNNS.Conclusions: Pharmacological treatment of NAS is associated with decreased DNAm of the OPRM1 gene and improved neonatal neurobehavior. Epigenetic changes may play a role in these changes in neonatal neurobehavior.


Cephalalgia ◽  
2006 ◽  
Vol 26 (5) ◽  
pp. 578-588 ◽  
Author(s):  
SE Jelinski ◽  
WJ Becker ◽  
SN Christie ◽  
R Giammarco ◽  
GF Mackie ◽  
...  

We set out to examine selected clinical characteristics of migraine patients referred to neurologists specializing in headache in Canada, and to document their pharmacological therapy both before and after consultation with the neurologist. Demographic, clinical and pharmacotherapy data were collected at the time of consultation for 606 patients referred to five headache clinics and who were given a migraine diagnosis by the neurologist. Data were analysed as part of the Canadian Headache Outpatient Registry and Database (CHORD) Project. The mean age of the migraine patients was 39.7 years; and 82.5% were female. The majority of patients suffered severe impact from their headaches. Prior to consultation, 48.7% were taking a triptan; after consultation, 97.2% were on a triptan. Before consultation, 30.9% were on a prophylactic drug; after consultation, 70.4% were. 20.8% of patients were medication overusers. Of these medication overusers, 42.4% were overusing an opiate, usually in combination with other analgesics; 21.6% were overusing a triptan. Medication changes made by the neurologists at consultation included a large increase in the use of both triptans and prophylactic medications. Medication overuse, particularly opiate overuse, remains a significant problem in patients with migraine in Canada.


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