Long-term changes induced by neonatal handling in the nociceptive threshold and body weight in mice

ObjectiveWe tested whether genetic variants near fatty acid desaturases gene (FADS) cluster, which were recently identified to be signatures of adaptation to fish-rich and n-3 polyunsaturated fatty acids (PUFAs)-rich diet, interacted with these dietary factors on change in body mass index (BMI).DesignThreeFADSvariants were examined for gene-diet interactions on long-term (~10 years) changes in BMI and body weight in four prospective cohort studies.SettingPopulation based study.Participants11 323 women from the Nurses’ Health Study (NHS), 6833 men from the Health Professionals Follow-up Study (HPFS) and replicated in 6254 women from the Women’s Health Initiative (WHI) and 5 264 Chinese from the Singapore Chinese Health Study (SCHS).Main outcomesLong-term (~10 years) changes in BMI and body weight.ResultsIn the NHS and HPFS cohorts, food-sourced n-3 PUFAs intake showed interactions with theFADSrs174570 on changes of BMI (P for interaction=0.02 in NHS, 0.05 in HPFS and 0.007 in combined). Such interactions were replicated in two independent cohorts WHI and SCHS (P for interaction=0.04 in WHI, 0.02 in SCHS and 0.001 in combined). The genetic associations of theFADSrs174570 with changes in BMI increased across the tertiles of n-3 PUFAs in all the cohorts. Fish intake also accentuated the genetic associations of theFADSrs174570 with long-term changes in BMI (pooled P for interaction=0.006). Viewed differently, long chain n-3 PUFAs intake showed stronger association with long-term changes in BMI among the rs174570 T carriers (beta=0.79 kg/m2per g, p=3×10−5) than the rs174570 non-T carriers (beta=0.16 kg/m2per g, p=0.08). Similar results were observed for fish intake.ConclusionsOur hypothesis-driven analyses provide replicable evidence that long chain n-3 PUFAs and fish intakes may interact with theFADSvariant on long-term weight gain. Further investigation is needed to confirm our findings in other cohorts.

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Long-term changes in body weight are associated with changes in blood pressure levels

Nutrition Metabolism and Cardiovascular Diseases ◽

10.1016/j.numecd.2014.10.011 ◽

2015 ◽

Vol 25 (3) ◽

pp. 305-311 ◽

Cited By ~ 5

Author(s):

M.R.P. Markus ◽

T. Ittermann ◽

S.E. Baumeister ◽

P. Troitzsch ◽

S. Schipf ◽

...

Keyword(s):

Blood Pressure ◽

Body Weight ◽

Long Term Changes

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Long-term changes in the ghrelin-CB1R axis associated with the maintenance of lower body weight after sleeve gastrectomy

Nutrition and Diabetes ◽

10.1038/nutd.2014.24 ◽

2014 ◽

Vol 4 (7) ◽

pp. e127-e127 ◽

Cited By ~ 11

Author(s):

C Fedonidis ◽

N Alexakis ◽

X Koliou ◽

O Asimaki ◽

E Tsirimonaki ◽

...

Keyword(s):

Body Weight ◽

Sleeve Gastrectomy ◽

Lower Body ◽

Lower Body Weight ◽

Long Term Changes

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β1-Adrenoceptor gene polymorphism predicts long-term changes in body weight

International Journal of Obesity ◽

10.1038/sj.ijo.0802892 ◽

2005 ◽

Vol 29 (5) ◽

pp. 458-462 ◽

Cited By ~ 31

Author(s):

Y Linné ◽

I Dahlman ◽

J Hoffstedt

Keyword(s):

Body Weight ◽

Gene Polymorphism ◽

Long Term Changes

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Adipose lipid turnover and long-term changes in body weight

Nature Medicine ◽

10.1038/s41591-019-0565-5 ◽

2019 ◽

Vol 25 (9) ◽

pp. 1385-1389 ◽

Cited By ~ 16

Author(s):

P. Arner ◽

S. Bernard ◽

L. Appelsved ◽

K.-Y. Fu ◽

D. P. Andersson ◽

...

Keyword(s):

Body Weight ◽

Long Term Changes ◽

Lipid Turnover

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Long-term changes in insulin action and insulin secretion associated with gain, loss, regain and maintenance of body weight

Diabetologia ◽

10.1007/s001250050005 ◽

2000 ◽

Vol 43 (1) ◽

pp. 36-46 ◽

Cited By ~ 59

Author(s):

C. Weyer ◽

K. Hanson ◽

C. Bogardus ◽

R. E. Pratley

Keyword(s):

Body Weight ◽

Insulin Secretion ◽

Insulin Action ◽

Long Term Changes ◽

Gain Loss

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Long-term changes in brain cholinergic system and behavior in rats following gestational exposure to lead: protective effect of calcium supplement

Interdisciplinary Toxicology ◽

10.1515/intox-2015-0025 ◽

2015 ◽

Vol 8 (4) ◽

pp. 159-168 ◽

Cited By ~ 14

Author(s):

Chand D. Basha ◽

Rajarami G. Reddy

Keyword(s):

Body Weight ◽

Protective Effect ◽

Cholinergic System ◽

Body Weight Gain ◽

Open Field Behavior ◽

Gestational Exposure ◽

Long Term Changes ◽

Pb Exposure ◽

And Behavior

Abstract Our earlier studies showed that lactational exposure to lead (Pb) caused irreversible neurochemical alterations in rats. The present study was carried out to examine whether gestational exposure to Pb can cause long-term changes in the brain cholinergic system and behavior of rats. The protective effect of calcium (Ca) supplementation against Pb toxicity was also examined. Pregnant rats were exposed to 0.2% Pb (Pb acetate in drinking water) from gestational day (GD) 6 to GD 21. The results showed decrease in body weight gain (GD 6–21) of dams, whereas no changes were observed in offspring body weight at different postnatal days following Pb exposure. Male offspring treated with Pb showed marginal alterations in developmental landmarks such as unfolding of pinnae, lower and upper incisor eruption, fur development, eye slit formation and eye opening on postnatal day (PND) 1, whereas significant alterations were found in the righting reflex (PNDs 4–7), slant board behavior (PNDs 8–10) and forelimb hang performance (PNDs 12–16). Biochemical analysis showed decrease in synaptosomal acetylcholinesterase (AChE) activity and an increase in acetylcholine (ACh) levels in the cortex, cerebellum and hippocampus on PND 14, PND 21, PND 28 and in the four-month age group of rats following Pb exposure. Significant deficits were also observed in total locomotor activity, exploratory behavior and open field behavior in selected age groups of Pb-exposed rats. These alterations were found to be maximal on PND 28, corresponding with the greater blood lead levels observed on PND 28. Addition of 0.02% Ca to Pb reversed the Pb-induced impairments in the cholinergic system as well as in behavioral parameters of rats. In conclusion, these data suggest that gestational exposure to Pb is able to induce long-term changes in neurological functions of offspring. Maternal Ca administration reversed these neurological effects of Pb later in life, suggesting a protective effect of calcium in Pb-exposed animals.

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β3-Adrenoceptor function and long-term changes in body weight

International Journal of Obesity ◽

10.1038/ijo.2009.54 ◽

2009 ◽

Vol 33 (6) ◽

pp. 662-668 ◽

Cited By ~ 10

Author(s):

D Andersson ◽

H Wahrenberg ◽

P Löfgren

Keyword(s):

Body Weight ◽

Long Term Changes

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The Benefits of a Weight Loss Contest in Overweight and Obese College Students

Recreational Sports Journal ◽

10.1123/rsj.32.1.45 ◽

2008 ◽

Vol 32 (1) ◽

pp. 45-51 ◽

Cited By ~ 1

Author(s):

Cynthia Ferrara ◽

Christine St. Laurent ◽

Thomas Wilson

Keyword(s):

Physical Activity ◽

College Students ◽

Body Mass Index ◽

Weight Loss ◽

Body Weight ◽

The Other ◽

Waist To Hip Ratio ◽

Percent Change ◽

Long Term Changes

The purpose of this study was to examine whether a weight loss contest would result in changes in body composition in college students. Students were invited to participate in a semester-long weight loss contest. Monthly “weigh-ins” included body weight, body mass index (BMI), percent fat, and circumference measurements. Thirty-nine participants registered for the contest. Only 41% of the original participants attended at least four weigh-ins ( n = 16). Those participants who attended at least four weigh-ins attended more education and exercise sessions than the other participants and significantly reduced their weight, BMI, percent fat, waist, and waist-to-hip ratio over the semester-long contest. Percent change in weight was associated with education ( r = –.39) and exercise sessions attended ( r = –.41). In conclusion, campus-based weight loss contests can be successful in promoting weight loss, although additional studies are needed to determine what factors increase adherence and whether such programs promote long-term changes in physical activity and diet.

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