Experimental studies of the abuse potential of d,l-glaucine·1.5-phosphate in rhesus monkeys

1982 ◽  
Vol 16 (5) ◽  
pp. 851-854 ◽  
Author(s):  
C.R. Schuster ◽  
T. Aigner ◽  
C.E. Johanson ◽  
T.H. Gieske
Keyword(s):  
Rhesus Monkeys ◽  
Experimental Studies ◽  
Abuse Potential

scholarly journals Abuse Potential of Phendimetrazine and its Effects on Cocaine Self‐Administration in Rhesus Monkeys

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Molly L. Minkiewicz ◽  
Paul W. Czoty ◽  
Bruce E. Blough ◽  
Michael A. Nader
Keyword(s):  
Rhesus Monkeys ◽  
Abuse Potential ◽  
Self Administration

A Correlated Scanning And Transmission Electron Microscopy Study of Pulmonary Airway Morphology in the Rhesus Monkey

1973 ◽  
Vol 31 ◽  
pp. 618-619
Author(s):  
W. L. Castleman ◽  
D. L. Dungworth
Keyword(s):  
Electron Microscopy ◽  
Rhesus Monkeys ◽  
Experimental Studies ◽  
Microscopy Study ◽  
Electron Microscopy Study ◽  
Transmission Electron ◽  
Critical Point Drying ◽  
Pulmonary Airways ◽  
Structural Differences ◽  
Airway Morphology

Previous research has indicated that there are important differences in the structure of pulmonary airways among various species of mammals and that these structural differences must be taken into consideration when animal models are being used in experimental studies of pulmonary disease. An investigation is being undertaken in this laboratory to characterize airway structure in several species of nonhuman primates and compare that structure with airway structure that has been described in man. The following is a report on studies of lungs from rhesus monkeys.Lungs from adult rhesus monkeys were, fixed via the airways with cacodylatebuffered glutaraldehyde-formaldehyde. Various levels of bronchi and bronchioles were bisected with razor blades. One half of the bisected airway was prepared for scanning electron microscopy by dehydration, critical point drying from CO2, and conductive coating with silver and gold.

scholarly journals Histopathologic findings of pulmonary acariasis in a rhesus monkeys breeding unit

2007 ◽  
Vol 16 (4) ◽  
pp. 229-234 ◽  
Author(s):  
Márcia Cristina R. Andrade ◽  
Renato S. Marchevsky
Keyword(s):  
Respiratory System ◽  
Macaca Mulatta ◽  
Rhesus Monkeys ◽  
Experimental Studies ◽  
Old World Monkeys ◽  
Old World ◽  
Thin Walled ◽  
Low Incidence ◽  
Histopathologic Findings

Histological lesions in the lungs of rhesus monkeys (Macaca mulatta) related with Pneumonyssus simicola were evidenced. The most prominent pathologic alterations included numerous thin-walled cysts 1-5 mm diameter scattered throughout the lungs, bronchiolitis, peribronchiolitis where the mites were found associated with pigmented and non-pigmented materials. Our study included data from 347 rhesus monkeys submitted to necropsies during 20 years. Four adult debilitated animals were found with pulmonary acariasis which showed a very low incidence of parasite (1.2%) in the colony. Most of the published literature described as common and widespread pulmonary acariasis in Old World monkeys. The present study confirms the ubiquity of P. simicola in captive born and raised rhesus monkeys that would compromise experimental studies involving the respiratory system.

Enhanced attention in rhesus monkeys as a common factor for the cognitive effects of drugs with abuse potential

2003 ◽  
Vol 169 (2) ◽  
pp. 150-160 ◽  
Author(s):  
John N. Bain ◽  
Mark A. Prendergast ◽  
Alvin V. Terry ◽  
Stephen P. Arneric ◽  
Mark A. Smith ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Common Factor ◽  
Abuse Potential ◽  
Cognitive Effects

scholarly journals Preserved visual memory and relational cognition performance in monkeys with selective hippocampal lesions

2020 ◽  
Vol 6 (29) ◽  
pp. eaaz0484 ◽  
Author(s):  
Benjamin M. Basile ◽  
Victoria L. Templer ◽  
Regina Paxton Gazes ◽  
Robert R. Hampton
Keyword(s):  
Nonhuman Primate ◽  
Source Memory ◽  
Rhesus Monkeys ◽  
Visual Memory ◽  
Temporal Order ◽  
Experimental Studies ◽  
Hippocampal Damage ◽  
Hippocampal Lesions ◽  
Hippocampus Proper ◽  
New Generation

The theory that the hippocampus is critical for visual memory and relational cognition has been challenged by discovery of more spared hippocampal tissue than previously reported in H.M., previously unreported extra-hippocampal damage in developmental amnesiacs, and findings that the hippocampus is unnecessary for object-in-context memory in monkeys. These challenges highlight the need for causal tests of hippocampal function in nonhuman primate models. Here, we tested rhesus monkeys on a battery of cognitive tasks including transitive inference, temporal order memory, shape recall, source memory, and image recognition. Contrary to predictions, we observed no robust impairments in memory or relational cognition either within- or between-groups following hippocampal damage. These results caution against over-generalizing from human correlational studies or rodent experimental studies, compel a new generation of nonhuman primate studies, and indicate that we should reassess the relative contributions of the hippocampus proper compared to other regions in visual memory and relational cognition.

scholarly journals EXPERIMENTAL STUDIES ON ENCEPHALITIS

1935 ◽  
Vol 61 (3) ◽  
pp. 411-422 ◽  
Author(s):  
Leslie T. Webster ◽  
George L. Fite
Keyword(s):  
Rhesus Monkeys ◽  
Kansas City ◽  
Average Pore Size ◽  
Experimental Studies ◽  
Immunological Response ◽  
Infectious Agent ◽  
High Dilution ◽  
Olfactory Bulbs ◽  
Average Pore ◽  
Fatal Reaction

1. The infectious agent from fatal cases of St. Louis and Kansas City encephalitis passes Seitz pads in high dilution without appreciable loss of infectivity and traverses collodion membranes with an average pore size of 66 mµ or greater. 2. It is highly infectious for mice by the intracerebral and intranasal routes, but practically innocuous by the subcutaneous and intraperitoneal routes. 3. Certain strains of mice are more susceptible than others. 4. The agent administered to mice intranasally causes tremors and convulsions after a 6 to 7 day incubation period, followed by prostration and death in 8 to 10 days. Lesions are demonstrable in the olfactory bulbs 3 days after infection, in the piriform lobe after 4 days, and in Ammon's horn after 5 days. 5. In Macacus rhesus monkeys, the agent provokes a mild, non-fatal reaction and the development of specific neutralizing bodies. On passage in monkeys, the virus becomes progressively weaker. 6. In rabbits, guinea pigs, rats, and sheep the agent is apparently without effect. 7. All available strains of the agent proved alike in effects in animals and in immunological response. 8. The available data enable one to conclude that the agent is a filtrable virus differing from those studied heretofore.

scholarly journals Using imaging photoplethysmography for heart rate estimation in non-human primates

2018 ◽  
Author(s):  
Anton M. Unakafov ◽  
Sebastian Möller ◽  
Igor Kagan ◽  
Alexander Gail ◽  
Stefan Treue ◽  
...  
Keyword(s):  
Heart Rate ◽  
Pulse Rate ◽  
Rhesus Monkeys ◽  
Emotional State ◽  
Physiological State ◽  
Experimental Studies ◽  
Invasive Technique ◽  
Rate Estimation ◽  
Non Invasive ◽  
Good Agreement

AbstractFor humans and for non-human primates heart rate is a reliable indicator of an individual’s current physiological state, with applications ranging from health checks to experimental studies of cognitive and emotional state. In humans, changes in the optical properties of the skin tissue correlated with cardiac cycles (imaging photoplethysmogram, iPPG) allow non-contact estimation of heart rate by its proxy, pulse rate. Yet, there is no established simple and non-invasive technique for pulse rate measurements in awake and behaving animals. Using iPPG, we here demonstrate that pulse rate in rhesus monkeys can be accurately estimated from facial videos. We computed iPPGs from seven color facial videos of three awake head-stabilized rhesus monkeys. Pulse rate estimated from iPPGs was in good agreement with reference data from a pulse-oximeter with error of pulse rate estimation below 5% for 82% of all epochs, and below 10% for 98% of the epochs. We conclude that iPPG allows non-invasive and non-contact estimation of pulse rate in non-human primates, which is useful for physiological studies and can be used toward welfare-assessment of non-human primates in research.

The Growth of Herpesvirus mulatto in Human Fibroblast

1974 ◽  
Vol 32 ◽  
pp. 244-245
Author(s):  
Glennelle Washington ◽  
Philip P. McGrath ◽  
Peter R. Graze ◽  
Ivor Royston
Keyword(s):  
Rhesus Monkey ◽  
Microscopic Study ◽  
Electron Microscopic Study ◽  
Peripheral Blood ◽  
Human Fibroblast ◽  
Rhesus Monkeys ◽  
Human Fibroblasts ◽  
Electron Microscopic ◽  
Specific Antisera ◽  
Peripheral Blood Leucocytes

Herpes-like viruses were isolated from rhesus monkey peripheral blood leucocytes when co-cultivated with WI-38 cells. The virus was originally designated rhesus leucocyte-associated herpesvirus (LAHV) and subsequently called Herpesvirus mulatta (HVM). The original isolations were from juvenile rhesus monkeys shown to be free of antibody to rhesus cytomegalic virus. The virus could only be propagated in human or simian fibroblasts. Use of specific antisera developed from HVM showed no relationship between this virus and other herpesviruses. An electron microscopic study was undertaken to determine the morphology of Herpesvirus mulatta (HVM) in infected human fibroblasts.

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