HLA DRB*1301-02 prevents from non-responsiveness against HBs-Ag immunization and from chronic hepatitis B; HLA DRB1*0301 and C4A*Q0 are factors at risk

1996 ◽  
Vol 47 (1-2) ◽  
pp. 32
Author(s):  
Rittner Christian ◽  
Gerken Guido ◽  
Notghi Arman ◽  
Stradmann-Bellinghausen Beate ◽  
Everke Petra ◽  
...  
Keyword(s):  
At Risk ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hbs Ag

scholarly journals Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study

2021 ◽  
Vol 27 (30) ◽  
pp. 5112-5125
Author(s):  
Mar Riveiro-Barciela ◽  
Cristina Marcos-Fosch ◽  
Fernando Martinez-Valle ◽  
Fabrizio Bronte ◽  
Olimpia Orozco ◽  
...  
Keyword(s):  
At Risk ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Prospective Study ◽  
Chronic Hepatitis B ◽  
Carotid Atherosclerosis ◽  
Hepatitis B E Antigen ◽  
A Prospective Study ◽  
Negative Chronic Hepatitis

scholarly journals Coexistence of Hepatitis B Surface Antigen (HBs Ag) and Anti-HBs Antibodies in Chronic Hepatitis B Virus Carriers: Influence of “a” Determinant Variants

2006 ◽  
Vol 80 (6) ◽  
pp. 2968-2975 ◽  
Author(s):  
Olivier Lada ◽  
Yves Benhamou ◽  
Thierry Poynard ◽  
Vincent Thibault
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Immune Escape ◽  
Hepatitis B Surface Antigen ◽  
Group I ◽  
Group Ii ◽  
Hbs Ag ◽  
Selection Of

ABSTRACT In chronic hepatitis B (CHB), the persistence of hepatitis B surface antigen (HBs Ag) is sometimes associated with antibodies (Ab) to HBs (anti-HBs). To assess the hypothesis of the selection of HBs Ag immune escape variants in CHB patients, the variability of the HBV S gene was determined for patients persistently carrying both HBs Ag and anti-HBs antibodies and patients solely positive for HBs Ag. We selected 14 patients who presented both markers (group I) in several consecutive samples and 12 patients positive for HBs Ag only (group II). The HBs Ag-encoding gene was amplified and cloned, and at least 15 clones per patient were sequenced and analyzed. The number of residue changes within the S protein was 2.7 times more frequent for group I than for group II patients and occurred mostly in the “a” determinant of the major hydrophilic region (MHR), with 9.52 versus 2.43 changes per 100 residues (P = 0.009), respectively. Ten patients (71%) from group I, but only three (25%) from group II, presented at least two residue changes in the MHR. The most frequent changes in group I patients were located at positions s145, s129, s126, s144, and s123, as described for immune escape variants. In CHB patients, the coexistence of HBs Ag and anti-HBs Ab is associated with an increase of “a” determinant variability, suggesting a selection of HBV immune escape mutants during chronic carriage. The consequences of this selection process with regard to vaccine efficacy, diagnosis, and clinical evolution remain partially unknown.

P1257 : Early identification of patients at risk for chronic hepatitis B and C in arnhem region, the Netherlands

2015 ◽  
Vol 62 ◽  
pp. S829
Author(s):  
G. Ter Beest ◽  
J. Gisolf ◽  
M. Belgers ◽  
T. Waegemaeckers ◽  
C. Swanink ◽  
...  
Keyword(s):  
At Risk ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
The Netherlands ◽  
Chronic Hepatitis B ◽  
Early Identification ◽  
Patients At Risk

scholarly journals Estimation of cellular immune response by evaluation of some cytokines in immunopathogenesis of chronic hepatitis B and C pre- and post- treated Iraqi patients (in vivo and in vitro)

2009 ◽  
Vol 6 (3) ◽  
pp. 533-541
Author(s):  
Baghdad Science Journal
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Healthy Control ◽  
Elisa Technique ◽  
The Mean ◽  
Hbs Ag ◽  
Cellular Immune

Two groups of chronic hepatitis B and C virus patients were divided into Pre-treated patients (25 CHB patients with positive HBs Ag for more than 6 months and 40 CHC patients), and post-treated patients [12 CHB patients (4, 6, and 2 were treated with lamivudine, IFN-? and combination of LMV + IFN-? respectively), and 27 patients for CHC (3, 13 and 11 patients were treated with Ribavirin, IFN-? and combination therapy (RBV+ IFN-?) respectively].These patients were followed up for 6 months. By using ELISA technique, levels of IL-6, IL-10, IFN-? and TNF-? were measured in vivo and in vitro (supernatant of PBMCs stimulated with PHA) and compared with healthy control. The mean level of IL-6, IL-10 and TNF-? in CHB patients showed significant differences (P

Engaging new refugee in Australian communities at risk for chronic hepatitis B infection into care: A peer-educator intervention

2018 ◽  
Vol 26 (5) ◽  
pp. 744-750 ◽  
Author(s):  
Katherine Sievert ◽  
Paul O'Neill ◽  
Youlin Koh ◽  
Jia-Hui Lee ◽  
Anouk Dev ◽  
...  
Keyword(s):  
At Risk ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hepatitis B Infection ◽  
Chronic Hepatitis B Infection ◽  
Peer Educator

scholarly journals Relationship among MIF, MCP-1, viral loads, and HBs Ag levelsin chronic hepatitis B patients

2015 ◽  
Vol 45 ◽  
pp. 634-637 ◽  
Author(s):  
Hayati GÜNEŞ ◽  
Rafet METE ◽  
Murat AYDIN ◽  
Birol TOPÇU ◽  
Mustafa ORAN ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Viral Loads ◽  
Hbs Ag

726 ADD-ON OF PEG-INTERFERON TO A STABLE NUCLEOS(T)IDE REGIMEN LEADS TO LOSS OF HBS-AG IN PATIENTS WITH CHRONIC HEPATITIS B

2011 ◽  
Vol 54 ◽  
pp. S291
Author(s):  
J.M. Kittner ◽  
M.F. Sprinzl ◽  
A. Grambihler ◽  
A. Weinmann ◽  
R.R. Galle ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Hbs Ag

scholarly journals Pencegahan Transmisi Vertikal Hepatitis B: Fokus pada Penggunaan Antivirus Antenatal

2017 ◽  
Vol 3 (4) ◽  
pp. 225
Author(s):  
Anandhara Indriani Khumaedi ◽  
Rino Alvani Gani ◽  
Irsan Hasan
Keyword(s):  
At Risk ◽  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Vertical Transmission ◽  
Horizontal Transmission ◽  
Virus Transmission ◽  
Developed Countries ◽  
Main Mode ◽  
Immunoprophylaxis Failure

Hepatitis B merupakan penyebab utama penyakit hati kronik dan dapat menyebabkan sirosis, gagal hati dan karsinoma hepatoselular pada 15-40% populasi. Terhitung sebanyak dua miliar penduduk dunia terinfeksi hepatitis B. Sebanyak 240 juta diantaranya mengidap hepatitis B kronik dan 780.000 jiwa meninggal karena komplikasi akut dan kronik hepatitis B. Transmisi hepatitis B berbeda di berbagai belahan dunia. Pada negara maju, transmisi hepatitis B sebagian besar melalui transmisi horizontal, sedangkan pada negara berkembang transmisi heptitis B 90% melalui transmisi vertikal. Upaya pencegahan transmisi vertikal berupa pemberian imunoglobulin mencapai tingkat keberhasilan hingga 95%, namun menyisakan sebagian kecil populasi yang mengalami kegagalan imunoprofilaksis yang berisiko untuk berkembang menjadi hepatitis B kronik. Pemberian antivirus pada saat antenatal berperan dalam mencegah transmisi vertikal pada populasi yang berisiko mengalami kegagalan imunoprofilaksis.Kata Kunci: analog nukleos(t)ida, hepatitis B, kegagalan imunoprofilaksis, transmisi vertikal  Prevention of Hepatitis B Vertical Transmission: Focus on Antenatal Antiviral AdministrationHepatitis B is one of the main cause of chronic liver disease, and potentially cause cirrhosis, liver failure and hepatocellular carcinoma in 15-40% population. Globally, 2 billion people are infected by Hepatitis B. Two hundred and forty million people are suffering from chronic hepatitis B, and more than 780 000 people are dying from both acute and chronic complication of hepatitis B. In developed countries, horizontal transmission is the main mode of virus transmission, while in developing countries vertical transmission occured in 90% population with hepatitis B. Immunoglobulin administration as a prevention strategy for vertical transmission has 95% success rate, but it left 5-10% of those who has immunoprophylaxis failure to be at risk to develop chronic hepatitis B. Antiviral administration during pregnancy is considered to prevent hepatitis B vertical transmission in population at risk on developing immunoprophylaxis failure. Keywords: hepatitis B, immunoprophylaxis failure, nucleos(t)ide analog, vertical transmission

Challenges to the effective delivery of health care to people with chronic hepatitis B in Australia

Sexual Health ◽  
2012 ◽  
Vol 9 (2) ◽  
pp. 131 ◽  
Author(s):  
Jack Wallace ◽  
Stephen McNally ◽  
Jacqui Richmond ◽  
Behzad Hajarizadeh ◽  
Marian Pitts
Keyword(s):  
Health Care ◽  
At Risk ◽  
Chronic Hepatitis ◽  
Primary Health Care ◽  
Hepatitis B ◽  
Health System ◽  
Chronic Hepatitis B ◽  
Health Professionals ◽  
Clinical Guidelines ◽  
Primary Health

Background The complexity of the hepatitis B natural history and its prevalence in specific populations in Australia challenges the capacity of the health system to deliver health care effectively to affected people. This study explores the challenges in delivering health care to people with chronic hepatitis B (CHB) in Australia. Methods: We conducted a grounded theory based qualitative study in which data were gathered from 70 in-depth interviews with government program officers, clinicians and health and community workers across Australia, and four focus group discussions with 40 health and community workers from the communities most at risk of CHB. Results: A systematic approach to screening populations at risk, including people born in countries with intermediate or high prevalence of CHB; consensus on clinical guidelines; development of a shared care framework for CHB involving general practitioners; and effective communication between patients and health professionals were identified as essential. Workforce development, particularly for primary health care professionals, and developing the knowledge and capacity of health professionals to communicate effectively with people with HBV were described as other major factors in reducing the barriers to CHB treatment in Australia. Conclusion: To improve the clinical management of people with CHB in Australia, the health system needs to encourage the screening of people at risk, improve access to clinical services, and the knowledge and communication skills of primary health care and community health service providers. This study supported developing a shared care model and related infrastructures including training programs, referral pathways and clinical guidelines.

Sign in / Sign up

Export Citation Format

Share Document