A comparative evaluation of the safety and immunogenicity of a single dose of unbuffered oral rhesus rotavirus serotype 3, rhesus/human reassortant serotypes 1, 2 and 4 and combined (tetravalent) vaccines in healthy infants

Vaccine ◽  
1993 ◽  
Vol 11 (7) ◽  
pp. 747-753 ◽  
Author(s):  
Michael E. Pichichero ◽  
Steven M. Marsocci ◽  
Anne B. Francis ◽  
John L. Green ◽  
Frank A. Disney ◽  
...  
Keyword(s):  
Single Dose ◽  
Comparative Evaluation ◽  
Healthy Infants

scholarly journals Comparative evaluation of pre-treatment medication on post-instrumentation pain: Randomized control trial.

2020 ◽  
Vol 6 (2) ◽  
pp. 22-27
Author(s):  
Atul Jain ◽  
Chahat Chabra ◽  
Abinay Agarwal ◽  
Rohit Sharma ◽  
Faisal Khan ◽  
...  
Keyword(s):  
Single Dose ◽  
Lower Incidence ◽  
Randomized Control Trial ◽  
Comparative Evaluation ◽  
Endodontic Treatment ◽  
Rotary Instruments ◽  
Randomized Control ◽  
Pre Treatment ◽  
Treatment Medication

Aims and Objectives: To comparatively evaluate, the effect of preoperative single dose, of paracetamol and ibuprofen on PIP, using two different rotary instruments. Materials and Methods: 60 patients were randomly premedicated, with either paracetamol or ibuprofen and canal was instrumented, with either Hyflex or Protaper Gold files. PIP was evaluated at 6, 12, 24, 48 and 72 hrs. Results: Lower incidence and intensity of PIP, occurred in patients, premedicated with Ibuprofen and where canal was instrumented with Hyflex. Conclusion: Use of Ibuprofen, as a premedication during endodontic treatment, with Hyflex rotary instruments, decreases PIP.

Immunogenicity of a Single Dose of Meningococcal Group C Conjugate Vaccine Given at 3 Months of Age to Healthy Infants in the United Kingdom

2012 ◽  
Vol 31 (6) ◽  
pp. 616-622 ◽  
Author(s):  
Helen Findlow ◽  
Ray Borrow ◽  
Nick Andrews ◽  
Pauline Waight ◽  
Elizabeth Sheasby ◽  
...  
Keyword(s):  
United Kingdom ◽  
Single Dose ◽  
Conjugate Vaccine ◽  
The United Kingdom ◽  
Healthy Infants ◽  
Meningococcal Group

Single-Dose Gabapentin Pharmacokinetics and Safety in Healthy Infants and Children

2001 ◽  
Vol 41 (5) ◽  
pp. 507-514 ◽  
Author(s):  
George M. Haig ◽  
Howard N. Bockbrader ◽  
David L. Wesche ◽  
Samuel W. Boellner ◽  
Daniele Ouellet ◽  
...  
Keyword(s):  
Single Dose ◽  
Infants And Children ◽  
Healthy Infants

scholarly journals Comparative evaluation of various analgesics in irreversible pulpitis to reduce pain

2021 ◽  
Vol 17 (2) ◽  
pp. 313-319
Author(s):  
Pradeep Solete ◽  
Keyword(s):  
Clinical Trial ◽  
Single Dose ◽  
Comparative Evaluation ◽  
Severe Pain ◽  
Statistical Significance ◽  
Control Group ◽  
Time Intervals ◽  
Root Canals ◽  
Pain Scores ◽  
Irreversible Pulpitis

It is of interest to evaluate a single dose of three different analgesics compared to placebo in patients with symptomatic irreversible pulpitis. 120 patients were enrolled with severe pain in this prospective clinical trial. Patients were randomly divided into four groups after shaping and cleaning of root canals. This includes placebo, piroxicam 20mg, acetaminophen 325mg with aceclofenac sodium 100mg and acetaminophen 650mg. Participants were given a questionnaire to note the pain scores at various time intervals (6 hrs, 12 hrs, and 24 hrs) along with the respective tablets in a concealed manner. Data thus collected was analyzed for statistical significance. The severity of pain decreased in all the three interventional groups compared to the control group (p <0.01) at 6 hours. Zerodol-P and dolonex showed better pain reduction in comparison to the placebo and dolo 650 group (p <0.05) at 12 and 24 hours. Data shows that both zerodol-P and dolonex groups had similar effects at all time intervals. Thus, a single dose of analgesic such as Zerodol-P and Dolonex following shaping and cleaning of root canals relieved pain at all time intervals of the treatment. However, Dolo 650 performed better during the initial 6hrs after completion of the shaping and cleaning of root canals compared to the placebo.

scholarly journals A COMPARATIVE EVALUATION OF SINGLE DOSE TRANSDERMAL PATCH OF DICLOFENAC VERSUS KETOPROFEN FOR POST OPERATIVE ANALGESIA IN ABDOMINAL HYSRETECTOMY.

2020 ◽  
pp. 1-2
Author(s):  
Gaurav Panchal ◽  
Bhavna Sojitra ◽  
Divyang Shah
Keyword(s):  
Social Sciences ◽  
Single Dose ◽  
Comparative Evaluation ◽  
Diclofenac Sodium ◽  
Abdominal Hysterectomy ◽  
Transdermal Patch ◽  
Efficacy And Safety ◽  
Rescue Analgesia ◽  
Number Of Patients ◽  
To Receive

Introduction: Transdermal patch is very simple and painless method for providing postoperative analgesia. The aim of the study was to compare the efficacy and safety of transdermal patch of ketoprofen in comparion to diclofenac for post operative analgesia. It is randomized observational study. Method: Thirty six patients of 18 to 60 years were randomly allocated to receive either ketoprofen or diclofenac transdermal patch at the end of surgery under spinal anaethesia. Stastical analyasis used, data were analysed using statistical package for social sciences version 15.0 and open EPI software version 2.3. The primary end point is VAS score and total requirement of rescue analgesic first 24 hours of surgery. The secondary end points are time to rescue analgesic and adverse effects like nausea and vomiting. Conclusion: Single dose transdermal patch of Ketoprofen provided better post operative analgesia as compared to diclofenac sodium patch in abdominal hysterectomy (infraumblical surgeries) and less number of patients required rescue analgesia in ketoprofen group.

Comparative evaluation of conjugate vaccines in theHaemophilus influenzaeinfection model

2000 ◽  
Vol 46 (4) ◽  
pp. 358-362
Author(s):  
Shuichi Miyazaki ◽  
Miharu Shintani ◽  
Tetsuya Matsumoto ◽  
Kazuhiro Tateda ◽  
Keizo Yamaguchi
Keyword(s):  
Single Dose ◽  
Mortality Rate ◽  
Murine Model ◽  
Large Dose ◽  
Comparative Evaluation ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Immunologic Response ◽  
Type B ◽  
Conjugate Vaccines

We used a murine model of Haemophilus influenzae type b (Hib) infection to analyze the immunologic response to two commercially available PRP conjugate vaccines (HbOC, PRP-T). The mortality rate in mice infected with a large dose of the bacteria after vaccination with HbOC or PRP-T at two and three doses was significantly lower than in non-vaccinated mice and mice vaccinated by one dose. Furthermore, for infections caused by a small bacterial dose, the mortality rate in mice vaccinated with one, two, or three doses was significantly lower than in non-vaccinated mice. The induction level of anti-PRP antibodies, especially IgG, in serum of mice vaccinated by two or three doses was higher than in those vaccinated with a single dose. Our results indicate that the dose of vaccine influences its efficacy in protecting against Hib infection. Our results also showed a lack of difference between two different PRP conjugate vaccines.

scholarly journals Safety evaluation following immunization of pentavalent vaccine (multi-dose vial): experiences and comparative study

2021 ◽  
Vol 8 (2) ◽  
pp. 243
Author(s):  
Bijoy Kumar Panda ◽  
Raveena Bajaj ◽  
Deepika Surve ◽  
Ruma Deshpande
Keyword(s):  
Single Dose ◽  
Side Effects ◽  
Comparative Study ◽  
Injection Site ◽  
Safety Evaluation ◽  
Post Vaccination ◽  
Pentavalent Vaccine ◽  
Healthy Infants ◽  
Combination Vaccines ◽  
The Common

Background: Combination vaccines have many benefits but sometimes may result in unexpected side effects which may make the vaccine unfit for administration particularly with multidose vials.Methods: Healthy infants aged 6-8 weeks who came for routine immunization of liquid pentavalent vaccine were included in the study. All infants were observed for 30 minutes, post vaccination. Telephonic interview was conducted to detect AEFIs at 1 week and 1 month post vaccination.Results: The common AEFIs were found to be fever and pain at injection site. A comparison of the incidence (per 100 doses) of AEFIs after 1st, 2nd and 3rd dose of pentavalent vaccine showed that AEFIs goes on reducing with dose. Incidence (per 100 doses) of fever and local AEFIs was more (statistically significant) with multi-dose vial pentavalent vaccine.Conclusions: The multi-dose vial liquid pentavalent vaccine was found to be equally tolerable compared to single-dose vial liquid pentavalent vaccine.

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